Association between Smoking and the Progression of Computed Tomography Findings in Chronic Pancreatitis
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Background/Aims: Smoking and alcohol intake are two wellknown risk factors for chronic pancreatitis. However, there are few studies examining the association between smoking and changes in computed tomography (CT) findings in chronic pancreatitis. The authors evaluated associations between smoking, drinking and the progression of calcification on CT in chronic pancreatitis. Methods: In this retrospective study, 59 patients with chronic pancreatitis who had undergone initial and follow-up CT between January 2002 and September 2010 were included. Progression of calcification among CT findings was compared according to the amount of alcohol intake and smoking. Results: The median duration of followup was 51.6 months (range, 17.1 to 112.7 months). At initial CT findings, there was pancreatic calcification in 35 patients (59.3%). In the follow-up CT, progression of calcification was observed in 37 patients (62.7%). Progression of calcification was more common in smokers according to the multivariate analysis (odds ratio [OR], 9.987; p=0.006). The amount of smoking was a significant predictor for progression of calcification in the multivariate analysis (OR, 6.051 in less than 1 pack per day smokers; OR, 36.562 in more than 1 pack per day smokers; p=0.008). Conclusions: Continued smoking accelerates pancreatic calcification, and the amount of smoking is associated with the progression of calcification in chronic pancreatitis.
Abstract
Background/Aims: Smoking and alcohol intake are two wellknown risk factors for chronic pancreatitis. However, there are few studies examining the association between smoking and changes in computed tomography (CT) findings in chronic pancreatitis. The authors evaluated associations between smoking, drinking and the progression of calcification on CT in chronic pancreatitis. Methods: In this retrospective study, 59 patients with chronic pancreatitis who had undergone initial and follow-up CT between January 2002 and September 2010 were included. Progression of calcification among CT findings was compared according to the amount of alcohol intake and smoking. Results: The median duration of followup was 51.6 months (range, 17.1 to 112.7 months). At initial CT findings, there was pancreatic calcification in 35 patients (59.3%). In the follow-up CT, progression of calcification was observed in 37 patients (62.7%). Progression of calcification was more common in smokers according to the multivariate analysis (odds ratio [OR], 9.987; p=0.006). The amount of smoking was a significant predictor for progression of calcification in the multivariate analysis (OR, 6.051 in less than 1 pack per day smokers; OR, 36.562 in more than 1 pack per day smokers; p=0.008). Conclusions: Continued smoking accelerates pancreatic calcification, and the amount of smoking is associated with the progression of calcification in chronic pancreatitis.
참고문헌 (18)
- Yadav D, "The epidemiology of pancreatitis and pancreatic cancer", Gastroenterology, 144, pp.1252~1261 (2013)
- Talamini G, "Alcohol and smoking as risk factors in chronic pancreatitis and pancreatic cancer", Dig Dis Sci, 44, pp.1303~1311 (1999)
- Maisonneuve P, "Cigarette smoking accelerates progression of alcoholic chronic pancreatitis", Gut, 54, pp.510~514 (2005)
- Law R, "Cigarette smoking is independently associated with chronic pancreatitis", Pancreatology, 10, pp.54~59 (2010)
- Yadav D, "Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis", Arch Intern Med, 169, pp.1035~1045 (2009)
- Talamini G, "Cigarette smoking: an independent risk factor in alcoholic pancreatitis", Pancreas, 12, pp.131~137 (1996)
- Hartwig W, "Cigarette smoke enhances ethanol-induced pancreatic injury", Pancreas, 21, pp.272~278 (2000)
- Steer ML, "Chronic pancreatitis", N Engl J Med, 332, pp.1482~1490 (1995)
- Stevens T, "Pathogenesis of chronic pancreatitis:an evidence-based review of past theories and recent developments", Am J Gastroenterol, 99, pp.2256~2270 (2004)
- Dufour MC, "The epidemiology of alcohol-induced pancreatitis", Pancreas, 27, pp.286~290 (2003)
- Chowdhury P, "Pathophysiological effects of nicotine on the pancreas: an update", Exp Biol Med, 227, pp.445~454 (2002)
- Cavallini G, "Effect of alcohol and smoking on pancreatic lithogenesis in the course of chronic pancreatitis", Pancreas, 9, pp.42~46 (1994)
- Bernard JP, "Inhibition of nucleation and crystal growth of calcium carbonate by human lithostathine", Gastroenterology, 103, pp.1277~1284 (1992)
- Etemad B, "Chronic pancreatitis: diagnosis, classification, and new genetic developments", Gastroenterology, 120, pp.682~707 (2001)
- Luetmer PH, "Chronic pancreatitis: reassessment with current CT", Radiology, 171, pp.353~357 (1989)
- Remer EM, "Imaging of chronic pancreatitis", Radiol Clin North Am, 40, pp.1229~1242 (2002)
- Choueiri NE, "Advanced imaging of chronic pancreatitis", Curr Gastroenterol Rep, 12, pp.114~120 (2010)
- Talamini G, "Smoking cessation at the clinical onset of chronic pancreatitis and risk of pancreatic calcifications", Pancreas, 35, pp.320~326 (2007)