Disability due to Inflammatory Bowel Disease Is Correlated with Drug Compliance, Disease Activity, and Quality of Life
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Background/Aims: The inflammatory bowel disease disability index (IBD-DI) was recently developed for IBD to assess the functional consequences and disease burden. We applied the IBD-DI to a Korean population and identified predictive factors influencing IBD-related disability. Methods: Between March and August 2015, 322 consecutive patients with IBD were prospectively recruited. Patients completed the IBD-DI questionnaire and Crohn’s and Ulcerative Colitis Questionnaire (CUCQ-8) for assessing quality of life. We examined the relationships between IBD-DI and disease activity or quality of life and analyzed predictive factors in Korean IBD patients. Results: Enrolled patients completed both questionnaires. Total IBD-DI was correlated with CUCQ-8 scores in both ulcerative colitis (r=0.636, p<0.001) and Crohn’s disease (r=0.711, p<0.001). Total IBD-DI was also correlated with disease activity in both ulcerative colitis (r= –0.224, p=0.003) and Crohn’s disease (r= –0.307, p<0.001). Better drug compliance was associated with lower disability (p=0.001) and higher quality of life (p=0.003). Conclusions: Disability from IBD was correlated with disease activity and poor quality of life. Better drug compliance was associated with lower disability and higher quality of life. Our findings indicate that physicians should emphasize the importance of medication compliance for IBD patients.
Abstract
Background/Aims: The inflammatory bowel disease disability index (IBD-DI) was recently developed for IBD to assess the functional consequences and disease burden. We applied the IBD-DI to a Korean population and identified predictive factors influencing IBD-related disability. Methods: Between March and August 2015, 322 consecutive patients with IBD were prospectively recruited. Patients completed the IBD-DI questionnaire and Crohn’s and Ulcerative Colitis Questionnaire (CUCQ-8) for assessing quality of life. We examined the relationships between IBD-DI and disease activity or quality of life and analyzed predictive factors in Korean IBD patients. Results: Enrolled patients completed both questionnaires. Total IBD-DI was correlated with CUCQ-8 scores in both ulcerative colitis (r=0.636, p<0.001) and Crohn’s disease (r=0.711, p<0.001). Total IBD-DI was also correlated with disease activity in both ulcerative colitis (r= –0.224, p=0.003) and Crohn’s disease (r= –0.307, p<0.001). Better drug compliance was associated with lower disability (p=0.001) and higher quality of life (p=0.003). Conclusions: Disability from IBD was correlated with disease activity and poor quality of life. Better drug compliance was associated with lower disability and higher quality of life. Our findings indicate that physicians should emphasize the importance of medication compliance for IBD patients.
참고문헌 (31)
- Rogala L, "Population-based controlled study of social support, self-perceived stress, activity and work issues, and access to health care in inflammatory bowel disease", Inflamm Bowel Dis, 14, pp.526~535 (2008)
- Peyrin-Biroulet L, "Longterm complications, extraintestinal manifestations, and mortality in adult Crohn’s disease in population-based cohorts", Inflamm Bowel Dis, 17, pp.471~478 (2011)
- Peyrin-Biroulet L, "The natural history of adult Crohn’s disease in population-based cohorts", Am J Gastroenterol, 105, pp.289~297 (2010)
- Colombel JF, "Measuring disability in IBD: the IBD disability index", Gastroenterol Hepatol (N Y), 9, pp.300~302 (2013)
- Peyrin-Biroulet L, "Development of the first disability index for inflammatory bowel disease based on the international classification of functioning, disability and health", Gut, 61, pp.241~247 (2012)
- Achleitner U, "Identification of areas of functioning and disability addressed in inflammatory bowel disease-specific patient reported outcome measures", J Crohns Colitis, 6, pp.507~517 (2012)
- El-Matary W, "Patient-reported outcome measures in inflammatory bowel disease", Can J Gastroenterol Hepatol, 28, pp.536~542 (2014)
- Leong RW, "Prospective validation study of the International Classification of Functioning, Disability and Health score in Crohn’s disease and ulcerative colitis", J Crohns Colitis, 8, pp.1237~1245 (2014)
- van der Have M, "Self-reported disability in patients with inflammatory bowel disease largely determined by disease activity and illness perceptions", Inflamm Bowel Dis, 21, pp.369~377 (2015)
- Molodecky NA, "Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review", Gastroenterology, 142, pp.46~54.e42 (2012)
- Cosnes J, "Epidemiology and natural history of inflammatory bowel diseases", Gastroenterology, 140, pp.1785~1794 (2010)
- Thia KT, "An update on the epidemiology of inflammatory bowel disease in Asia", Am J Gastroenterol, 103, pp.3167~3182 (2008)
- Hou JK, "Distribution and manifestations of inflammatory bowel disease in Asians, Hispanics, and African Americans: a systematic review", Am J Gastroenterol, 104, pp.2100~2109 (2009)
- Yang SK, "Epidemiology of inflammatory bowel disease in the Songpa-Kangdong district, Seoul, Korea, 1986-2005: a KASID study", Inflamm Bowel Dis, 14, pp.542~549 (2008)
- Wee Khoon Ng, "Changing epidemiological trends of inflammatory bowel disease in Asia", Intestinal research, 14(2), pp.111~119 (2016), 대한장연구학회
- Ng SC, "Incidence and phenotype of inflammatory bowel disease based on results from the Asia- Pacific Crohn’s and colitis epidemiology study", Gastroenterology, 145, pp.158~165.e2 (2013)
- Alrubaiy L, "Development of a short questionnaire to assess the quality of life in Crohn’s disease and ulcerative colitis", J Crohns Colitis, 9, pp.66~76 (2015)
- Katsanos KH, "Fast-track drug approval in inflammatory bowel diseases", Ann Gastroenterol, 29, pp.439~444 (2016)
- Schroeder KW, "Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study", N Engl J Med, 317, pp.1625~1629 (1987)
- Morisky DE, "Concurrent and predictive validity of a self-reported measure of medication adherence", Med Care, 24, pp.67~74 (1986)
- Kane SV, "Systematic review: adherence issues in the treatment of ulcerative colitis", Aliment Pharmacol Ther, 23, pp.577~585 (2006)
- Jackson CA, "Factors associated with non-adherence to oral medication for inflammatory bowel disease: a systematic review", Am J Gastroenterol, 105, pp.525~539 (2010)
- Kiebles JL, "Preliminary evidence supporting a framework of psychological adjustment to inflammatory bowel disease", Inflamm Bowel Dis, 16, pp.1685~1695 (2010)
- "WHO disability assessment schedule 2.0" (2016)[URL]
- McLaughlin TJ, "Improving psychologic adjustment to chronic illness in cardiac patients: the role of depression and anxiety", J Gen Intern Med, 20, pp.1084~1090 (2005)
- Israeli E, "Low prevalence of disability among patients with inflammatory bowel diseases a decade after diagnosis", Clin Gastroenterol Hepatol, 12, pp.1330~1337.e2 (2014)
- Peyrin-Biroulet L, "Disability in inflammatory bowel diseases: developing ICF Core Sets for patients with inflammatory bowel diseases based on the International Classification of Functioning, Disability, and Health", Inflamm Bowel Dis, 16, pp.15~22 (2010)
- Allen PB, "Moving towards disease modification in inflammatory bowel disease therapy", Curr Opin Gastroenterol, 29, pp.397~404 (2013)
- Feagan BG, "Unemployment and disability in patients with moderately to severely active Crohn’s disease", J Clin Gastroenterol, 39, pp.390~395 (2005)
- Wang YF, "Progression of inflammatory bowel disease in China", J Dig Dis, 11, pp.76~82 (2010)
- Ananthakrishnan AN, "Permanent work disability in Crohn’s disease", Am J Gastroenterol, 103, pp.154~161 (2008)