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Influence of Cytokine Genetic Polymorphisms in Helicobacter pylori -Associated Gastric Inflammation According to Sex in South Korea

Influence of Cytokine Genetic Polymorphisms in Helicobacter pylori-Associated Gastric Inflammation According to Sex in South Korea

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Background/Aims: The relationship between genetic polymorphisms and gastric inflammation remains unclear. This study aimed to evaluate the impact of genetic polymorphisms on Helicobacter pylori (HP)-associated gastritis according to sex. Methods: Two hundred thirty-two male and 404 female subjects with current HP infection were prospectively enrolled. The genotyping of IL-1B-511 C/T, IL-1RN variable number of tandem repeats, IL-6-572 G/C, IL-8-251 A/T, IL-8-781 C/T, IL-10-1082 G/A, IL-10-592 C/A, TNF-A-308 G/A, and transforming growth factor (TGF)-B-509 C/T, was determined by polymerase chain reaction-restriction fragment length polymorphism. The degree of monocyte or neutrophil infiltration, atrophic gastritis, and intestinal metaplasia was evaluated using the updated Sydney system. Results: Among the male subjects, moderate/severe atrophic gastritis of the corpus was higher in IL-1B-511 CC carriers than in CT and TT carriers independent of age, alcohol consumption, and HP virulence factors (26.9% vs 10.4%; adjusted hazard ratio [HR], 4.377; 95% confidence interval, 1.387 to 13.814). In females, IL-8-251 AA carriers were independently and significantly associated with moderate/severe atrophic gastritis of the corpus compared with that in AT and TT carriers (21.4% vs 6.0%, adjusted HR=3.799). In males, the IL-8-251 TT genotype was associated with moderate/severe intestinal metaplasia of the corpus compared with the AT and AA genotypes (13.4% vs 5.6%, adjusted HR=3.128), while the IL-10-592 CA and CC genotypes were associated with moderate/severe monocyte infiltration of the antrum compared with AA genotype (83.6% vs 71.8%, adjusted HR=2.227). Conclusions: Genetic polymorphisms in cytokines play different roles in HP-associated gastritis according to sex.

Abstract

Background/Aims: The relationship between genetic polymorphisms and gastric inflammation remains unclear. This study aimed to evaluate the impact of genetic polymorphisms on Helicobacter pylori (HP)-associated gastritis according to sex. Methods: Two hundred thirty-two male and 404 female subjects with current HP infection were prospectively enrolled. The genotyping of IL-1B-511 C/T, IL-1RN variable number of tandem repeats, IL-6-572 G/C, IL-8-251 A/T, IL-8-781 C/T, IL-10-1082 G/A, IL-10-592 C/A, TNF-A-308 G/A, and transforming growth factor (TGF)-B-509 C/T, was determined by polymerase chain reaction-restriction fragment length polymorphism. The degree of monocyte or neutrophil infiltration, atrophic gastritis, and intestinal metaplasia was evaluated using the updated Sydney system. Results: Among the male subjects, moderate/severe atrophic gastritis of the corpus was higher in IL-1B-511 CC carriers than in CT and TT carriers independent of age, alcohol consumption, and HP virulence factors (26.9% vs 10.4%; adjusted hazard ratio [HR], 4.377; 95% confidence interval, 1.387 to 13.814). In females, IL-8-251 AA carriers were independently and significantly associated with moderate/severe atrophic gastritis of the corpus compared with that in AT and TT carriers (21.4% vs 6.0%, adjusted HR=3.799). In males, the IL-8-251 TT genotype was associated with moderate/severe intestinal metaplasia of the corpus compared with the AT and AA genotypes (13.4% vs 5.6%, adjusted HR=3.128), while the IL-10-592 CA and CC genotypes were associated with moderate/severe monocyte infiltration of the antrum compared with AA genotype (83.6% vs 71.8%, adjusted HR=2.227). Conclusions: Genetic polymorphisms in cytokines play different roles in HP-associated gastritis according to sex.

참고문헌 (49)

  1. McColl KE, "Clinical practice : Helicobacter pylori infection", N Engl J Med, 362, pp.1597~1604 (2010)
  2. Kim JM, "Helicobacter pylori", pp.77~88 (2016), Springer
  3. Chang YW, "Combination of Helicobacter pylori infection and the interleukin 8-251 T > A polymorphism, but not the mannose-binding lectin 2 codon 54 G > A polymorphism, might be a risk factor of gastric cancer", BMC Cancer, 17, pp.388~ (2017)
  4. de Brito BB, "Role of polymorphisms in genes that encode cytokines and Helicobacter pylori virulence factors in gastric carcinogenesis", World J Clin Oncol, 9, pp.83~89 (2018)
  5. Rudnicka K, "Genetic polymorphisms in inflammatory and other regulators in gastric cancer : risks and clinical consequences", Curr Top Microbiol Immunol, 421, pp.53~76 (2019)
  6. Sugimoto M, "Influence of inflammatory cytokine polymorphisms on eradication rates of Helicobacter pylori", J Gastroenterol Hepatol, 24, pp.1725~1732 (2009)
  7. Crusius JB, "Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition(EPIC-EURGAST)", Ann Oncol, 19, pp.1894~1902 (2008)
  8. Persson C, "Polymorphisms in inflammatory response genes and their association with gastric cancer : a HuGE systematic review and meta-analyses", Am J Epidemiol, 173, pp.259~270 (2011)
  9. Sun X, "Association between IL-1β polymorphisms and gastritis risk: a meta-analysis", Medicine(Baltimore), 96, pp.e6001~ (2017)
  10. Yan LR, "Single nucleotide polymorphisms of whole genes and atrophic gastritis susceptibility : a systematic review and meta-analysis", Gene, 782, pp.145543~ (2021)
  11. Global Burden of Disease Cancer Collaboration, "Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990to 2017 : a systematic analysis for the global burden of disease study", JAMA Oncol, 5, pp.1749~1768 (2019)
  12. Song DH, "Analysis of characteristics and risk factors of patients with single gastric cancer and synchronous multiple gastric cancer among 14, 603 patients", Gut Liver, 18, pp.231~244 (2024)
  13. Joo YE, "Prevalence and risk factors of atrophic gastritis and intestinal metaplasia : a nationwide multicenter prospective study in Korea", Gut Liver, 7, pp.303~310 (2013)
  14. Kato S, "Sex differences in mucosal response to Helicobacter pylori infection in the stomach and variations in interleukin-8, COX-2 and trefoil factor family 1 gene expression", Aliment Pharmacol Ther, 20(Suppl 1), pp.17~24 (2004)
  15. Kim N, "Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease", Helicobacter, 13, pp.245~255 (2008)
  16. Kim YS, "Sex-gender differences in irritable bowel syndrome", J Neurogastroenterol Motil, 24, pp.544~558 (2018)
  17. Hwang YJ, "The difference of endoscopic and histologic improvements of atrophic gastritis and intestinal metaplasia after Helicobacter pylori eradication", Dig Dis Sci, 67, pp.3055~3066 (2022)
  18. Shin CM, "Changes in aberrant DNA methylation after Helicobacter pylori eradication : a longterm follow-up study", Int J Cancer, 133, pp.2034~2042 (2013)
  19. Dixon MF, "Classification and grading of gastritis: the updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994", Am J Surg Pathol, 20, pp.1161~1181 (1996)
  20. Kim N, "The effects of genetic polymorphisms of IL-1 and TNF-A on Helicobacter pylori-induced gastroduodenal diseases in Korea", Helicobacter, 11, pp.105~112 (2006)
  21. Yamaoka Y, "Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome : studies in four different countries", J Clin Microbiol, 37, pp.2274~2279 (1999)
  22. Yamaoka Y, "A M(r)34, 000 proinflammatory outer membrane protein(oipA)of Helicobacter pylori", Proc Natl Acad Sci U S A, 97, pp.7533~7538 (2000)
  23. Lu W, "Genetic polymorphisms of interleukin(IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population", Carcinogenesis, 26, pp.631~636 (2005)
  24. Furuta T, "Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan", Gastroenterology, 123, pp.92~105 (2002)
  25. Hwang IR, "Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in Helicobacter pylori infection", Gastroenterology, 123, pp.1793~1803 (2002)
  26. Rad R, "Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection", Gut, 53, pp.1082~1089 (2004)
  27. Rech TF, "Analysis of the influence of interleukin-1β gene polymorphism on gastric inflammatory response and precancerous lesions development in patients with functional dyspepsia", Immunol Invest, 49, pp.585~596 (2020)
  28. Ohyauchi M, "The polymorphism interleukin 8-251 A", T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population, 2005, pp.54, 330~335
  29. Ye BD, "The interleukin-8-251 A allele is associated with increased risk of noncardia gastric adenocarcinoma in Helicobacter pyloriinfected Koreans", J Clin Gastroenterol, 43, pp.233~239 (2009)
  30. Naito M, "Associations of plasma IL-8levels with Helicobacter pylori seropositivity, gastric atrophy, and IL-8 T-251A genotypes", Epidemiol Infect, 138, pp.512~518 (2010)
  31. Taguchi A, "Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan", Cancer Epidemiol Biomarkers Prev, 14, pp.2487~2493 (2005)
  32. Zambon CF, "Pro-and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection : interactions influence outcome", Cytokine, 29, pp.141~152 (2005)
  33. Li ZW, "Inflammatory cytokine gene polymorphisms increase the risk of atrophic gastritis and intestinal metaplasia", World J Gastroenterol, 16, pp.1788~1794 (2010)
  34. Hull J, "Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families", Thorax, 55, pp.1023~1027 (2000)
  35. Canedo P, "The interleukin-8-251*T", *A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population, 2008, pp.17, 28~32
  36. Savage SA, "Interleukin-8 polymorphisms are not associated with gastric cancer risk in a Polish population", Cancer Epidemiol Biomarkers Prev, 15, pp.589~591 (2006)
  37. Kamangar F, "Polymorphisms in inflammation-related genes and risk of gastric cancer(Finland)", Cancer Causes Control, 17, pp.117~125 (2006)
  38. Song B, "Association of interleukin-8 with cachexia from patients with low-third gastric cancer", Comp Funct Genomics, 2009, pp.212345~ (2009)
  39. Barboza MMO, "Contribution of genetic polymorphisms of interleukins IL1B-511 C", T, IL1RN VNTR, IL6-174 G, T in gastric lesions : gender and Helicobacter pylori genes matter, pp.Arch Microbiol, 2021[DOI]
  40. Abbasi A, "Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise", J Neuroinflammation, 13, pp.289~ (2016)
  41. Martínez-Carrillo DN, "Association of IL1B-511C", -31T haplotype and Helicobacter pylori vacA genotypes with gastric ulcer and chronic gastritis, 2010, pp.10, 126~
  42. Kim J, "Effects of interleukin-10polymorphisms, Helicobacter pylori infection, and smoking on the risk of noncardia gastric cancer", PLoS One, 7, pp.e29643~ (2012)
  43. Suárez A, "Interindividual variations in constitutive interleukin-10 messenger RNA and protein levels and their association with genetic polymorphisms", Transplantation, 75, pp.711~717 (2003)
  44. Zhu Y, "The association between interleukin-10-592 polymorphism and gastric cancer risk : a meta-analysis", Med Oncol, 28, pp.133~136 (2011)
  45. Yu Z, "The interleukin 10-819C", T polymorphism and cancer risk : a HuGE review and meta-analysis of 73 studies including 15, 942 cases and 22, 336 controls, 2013, pp.17, 200~214
  46. Li C, "The-1082A>G polymorphism in promoter region of interleukin-10 and risk of digestive cancer : a meta-analysis", Sci Rep, 4, pp.5335~ (2014)
  47. Xue H, "A meta-analysis of interleukin-10-592 promoter polymorphism associated with gastric cancer risk", PLoS One, 7, pp.e39868~ (2012)
  48. Al-Serri A, "The SOD2 C47T polymorphism influences NAFLD fibrosis severity : evidence from case-control and intra-familial allele association studies", J Hepatol, 56, pp.448~454 (2012)
  49. Yao B, "The correlation of Th22 and regulatory T cells with Helicobacter pylori infection in patients with chronic gastritis", Immun Inflamm Dis, 11, pp.e768~ (2023)

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