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강황이 난황의 비강내 점적을 통하여 유발된 생쥐의 천식에 미치는 영향

Effects of Curcuma longa Rhizoma on Asthma induced intra-nasal instillation of Ovalbumin in Mice

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Objective : This study was designed to investigate the effects of Curcuma longa Rhizoma(CLR) on asthma. Methods : Detecting splenocyte proliferation rates, cytokines and antigen specific antibody isotypes in bronchoalveolar lavage fluid (BALF). In addition, the present author I also investigated changes in spleen and histopathological changes of lung tissues. Results : Oral administration of CLR lowered spleen weight and splenocyte proliferation rates. In addition, levels of IL-4, IL-17A and Granulocyte/Macrophage Colony-Stimulating Factor(GM-CSF), Th2 driven cytokines, were lowered respectively and IFN-g, and Th1 driven cytokine, were elevated by CLR. Levels of Ovalbumin(OVA) specific IgE and IgG1 in BALF were also lowered by oral administration of CLR too. Conclusion : CLR is useful to treat patients with asthma and the mechanisms are related to the in suppression of Th2 skewing reactions.

Abstract

Objective : This study was designed to investigate the effects of Curcuma longa Rhizoma(CLR) on asthma. Methods : Detecting splenocyte proliferation rates, cytokines and antigen specific antibody isotypes in bronchoalveolar lavage fluid (BALF). In addition, the present author I also investigated changes in spleen and histopathological changes of lung tissues. Results : Oral administration of CLR lowered spleen weight and splenocyte proliferation rates. In addition, levels of IL-4, IL-17A and Granulocyte/Macrophage Colony-Stimulating Factor(GM-CSF), Th2 driven cytokines, were lowered respectively and IFN-g, and Th1 driven cytokine, were elevated by CLR. Levels of Ovalbumin(OVA) specific IgE and IgG1 in BALF were also lowered by oral administration of CLR too. Conclusion : CLR is useful to treat patients with asthma and the mechanisms are related to the in suppression of Th2 skewing reactions.

참고문헌 (60)

  1. 李珩九, "東醫肺系內科學", pp.187~202 (1999), 서울:아트동방
  2. Adelroch, E, "Do physicians need objective measurements to diagnose asthma?", Am. Rev. Respir. Dis, 134, pp.704~7 (1986)
  3. Palmerio, EM, "Probability of asthma based on mechacholine challenge", chest, 01, pp.630~3 (1992)
  4. Kay, AB, "Asthma and Inflammation", J. Allergy. Chin. Immunol, 87, pp.893~910 (1991)
  5. 한의과 대학 본초학 편찬위원회, "본초학", pp.457~8 (2004), 서울: 영림사
  6. 정동환, "반하가 난황으로 유발된 생쥐의 알레르기성 천식에 미치는 영향", 한방안이비인후피부과학회지, 21(1), pp.38~54 (2008), 대한한방안이비인후피부과학회
  7. 정승현, "강황(Curcuma longa L.)으로부터 초임계 유체 추출한 curcumin의 생리활성", 한국식품과학회지, 36(2), pp.317~320 (2004), 한국식품과학회
  8. Tsitoura DC, "Mechanisms preventing allergen-induced airways hyperreactivity: role of tolerance and immune deviation", J Allergy Clin Immunol, 106(2), pp.239~46 (2000)
  9. 김형우, "蔘蘇飮이 천식이 유발된 생쥐의 cytokine 분비에 미치는 영향", 대한본초학회지, 22(2), pp.175~180 (2007), 대한본초학회
  10. Wysocki, L.J, "“Planning” for lymphocytes ; A method for cell selection", Proc. Nat1. Acad. Sci. USA, 75(6), pp.2844~8 (1978)
  11. Mizel, SB, "Regulation of lymphocyte-activating factor (LAF) production and secretion in P388D1 cells ; identification of high molecular weight precursors of LAF", J. Immunol. Methods, 122(6), pp.2173~9 (1979)
  12. Upon MN, "Intergeneration 20year trends in the prevalence of ashma and hay fever in adult:the Midspan family study surveys of parents and offspring", BMJ, 31, pp.88~92 (2000)
  13. 吉村永星, "알레르기성 천식에 관한 문헌적 고찰(동서의학적 비교고찰)", 大韓韓醫學會誌, 11(1), pp.39~70 (1990)
  14. 巢元方, "諸病源候論", pp.106~17 (1992), 서울:대성문화사
  15. 朱橚, "普濟方", pp.1789~ (1982), 北京:人民衛生出版社
  16. 樓英, "醫學綱目", pp.598~ (1996), 北京:中國中醫藥出版社
  17. 張介賓, "景岳全書", pp.429~ (1973), 台北:台聯國風出版社
  18. 박찬국, "黃帝內徑素問注釋", pp.455~813, 서울:집문당
  19. 영추연구집성간행위원회, "靈樞硏究集成(上)", pp.229~ (2006), 서울:청운인쇄
  20. 전국 한의과대학 폐계내과학 교실, "東醫肺係內科學", pp.178~9 (2002), 서울:한문화사
  21. 楊思澍, "중의임상대전", pp.87~100 (1993), 서울:의성당
  22. 남세현, "絲瓜絡 藥鍼의 喘息抑制 및 免疫調節效果에 對한 實驗的 硏究", 대한침구의학회지, 22(4), pp.73~86 (2005), 대한침구의학회
  23. 최가원, "款冬花藥鍼의 喘息抑制 및 免疫調節效果에 對한 實驗的 硏究", 대한침구의학회지, 24(1), pp.195~207 (2007), 대한침구의학회
  24. 임성철, "葶藶子藥鍼의 喘息抑制 및 免役調節效果에 대한 실험적 연구", 대한침구학회지, 24(3), pp.39~62 (2007)
  25. 박연철, "喘息의 鍼治療에 대한 최근 硏究動向", 대한침구학회지, 24(1), pp.217~225 (2007), 대한침구학회
  26. Osman, A, "Effects of turkish spice extracts at various concentrations on the growth of Escherichia coli 0157:H7", J. Microbiol, 19, pp.473~80 (2002)
  27. Jayaprakasha GK, "Chemistry and biological activities of C. longa", Trend Food Sci. Technol, 16, pp.533~48 (2005)
  28. Ryu GY, "Study of seperation and analysis method an effective component from UIGeum(Curcuma longa) and a cantained curcumin as product of national and partial region cultures", Appl. Chem, 9, pp.57~60 (2005)
  29. 최성규, "우리 나라 남부지역에서 강황(Curcuma longa L.)의 생육특성", 한국약용작물학회지, 12(1), pp.85~88 (2004), 한국약용작물학회
  30. 조수인, "薑黃 추출물이 유방암 세포주 MCF-7 증식 억제에 미치는 영향", 대한본초학회지, 21(1), pp.71~77 (2006), 대한본초학회
  31. Tsitoura DC, "Mechanisms preventing allergen-induced airways hyperreactivity: role of tolerance and immune deviation", J Allergy Clin Immunol, 106(2), pp.239~46 (2000)
  32. Li AM, "Induced sputum in childhood asthma", Hong Kong Med J, 11, pp.289~94 (2005)
  33. Smith JG Jr, "Corticosteroid-induced cutaneous atrophy and telangiectasia. Experimental production associated with weight loss in rats", Arch Dermatol, 112(8), pp.1115~7 (1976)
  34. Thomas Kindt, "Kuby immunology", pp.289~91 (2006), New York:W. H. Freeman and Company
  35. Kurt J. lsselbacher, "Principles of Internal Medicine", Diabetes Mellitus, 11, pp.1757~77 (1987)
  36. Spina D, "Modulation of sensory nerve function in the airways", Trends Pharmacol Sci, 19, pp.460~5 (1998)
  37. Fahy JV, "Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation", J Allergy Clin Immunol, 95, pp.843~52 (1995)
  38. Mosmann TR, "Two types of murine helper T cell clone. I Definition according to profiles of lymphokine activities and secreted proteins", J. Immunol, 136, pp.2348~57 (1986)
  39. Mosmann TR, "TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properities", Annu. Rev. Immunol, 7, pp.45~73 (1989)
  40. Coffman RL, "The role of helper Tcell products in mouse B cell differentiation and isotupe regulation", Immunol. Rev, 138, pp.3688~94 (1998)
  41. Spina D, "Modulation of sensory nerve function in the airways", Trends Pharmacol Sci, 19, pp.460~5 (1998)
  42. Fahy JV, "Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation", J Allergy Clin Imm, 95, pp.843~52 (1995)
  43. Welgus HG, "Human alveolar macrophages produce a fibroblastlike collagenase and collagenase inhibitor", J Clin Invest, 76, pp.219~24 (1985)
  44. Kasakura S, "A role for T-helper type 1and type 2 cytokines in the pathogenesis of various human disease", Rinsho Byori, 46, pp.915~21 (1998)
  45. Wen MC, "Efficacy and tolerability of anti-asthma herbal medicine intervention in adult patients with moderate-severe allergic asthma", J Allergy Clin Immunol, 116, pp.517~24 (2005)
  46. Lynch EL, "Immuno- modulatory cytokines in asthmatic inflammation", Cytokine Growth Factor Rev, 14(6), pp.489~502 (2003)
  47. Medoff BD, "IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma", J Immunol (2002)
  48. Corry DB, "Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity", J Exp Med, 183(1), pp.109~17 (1996)
  49. Wardlaw AJ, "New insights into the relationship between airway inflammation and asthma", Clin Sci (Lond), 103(2), pp.201~11 (2002)
  50. Welgus HG, "Human alveolar macrophages produce a fibroblastlike collagenase and collagenase inhibitor", J Clin Invest, 76, pp.219~24 (1985)
  51. Sergejeva S, "Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation", Am J Respir Cell Mol Biol, 33(3), pp.248~53 (2005)
  52. Barczyk A, "Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine", Respir Med, 97(6), pp.726~33 (2003)
  53. Molet S, "IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines", J Allergy Clin Immunol, 108(3), pp.430~8 (2001)
  54. Ip WK, "Interleukin-3, -5, and granulocyte macrophage colony-stimulating factor induce adhesion and chemotaxis of human eosinophils via p38 mitogen-activated protein kinase and nuclear factor kappaB", Immunopharmacol Immunotoxicol, 27(3), pp.371~93 (2005)
  55. Alam R, "Increased MCP-1, RANTES, and MIP-1in bronchoalveolarlavage fluid of allergic asthmatic patients", Am J Respir Crit Care Med, 153, pp.1398~404 (1996)
  56. Bodey KJ, "Cytokine profiles of BAL T cells and T-cell clones obtained from human asthmatic airways after local allergen challenge", Allergy, 54, pp.1083~93 (1999)
  57. Fedor ME, "Effects of long-term low-dose corticosteroid therapy on humoral immunity", Ann Allergy Asthma Immunol, 97(1), pp.113~6 (2006)
  58. Balzar S, "IgE expression pattern in lung: Relation to systemic IgE and asthma phenotypes", J Allergy Clin Immunol, 119(4), pp.855~62 (2007)
  59. Chakir J, "Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression", J Allergy Clin Immunol, 111, pp.1293~8 (2003)
  60. Magnan A, "Role of eosinophilia in atopic pathology", Med Trop, 58, pp.444~6 (1998)

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