본문 바로가기
KERD
논문KCI 등재

고지방식이로 비만을 유발한 마우스의 알레르기 비염에 대한 防風通聖散의 효과

The Effect of Bangpungtongsungsan on Allergic Rhinitis Of Obese Mouse Fed High Fat Diet

홍승욱|김동현
대한한방안이비인후피부과학회 (The Korean Medicine Opthalmology&Otolaryngology&Dermatology Society)|2016.02|한방안이비인후피부과학회지 (The Journal of Korean Medicine Ophthalmology&Otorhinolaryngology&Dermatology)|제29권 제1호|pp. 1-15|DOI http://dx.doi.org/10.6114/jkood.2016.29.1.001

0

조회

0

다운로드

3

인용

0

참고문헌

키워드

obesityTNF-αBangpungtongsungsanallergy rhinitisHigh Fat Diet
주제분류한의학

초록

Objective : For various reasons, Obesity & Rhinitis are constantly rising. So Interest of treatment has been expanding. We want to verify The Chungyeol (fire extinguishing) Lisup (Draining) effect of Bangpungtongsungsan on obese model of allergy rhinitis. Material and Methods : BALB/c mouse were divided four groups: control(CON), allergic induction(ARE), Bangpungtongsungsan extract administration(BTT), Bangpungtongsungsan double concentration extract administration (BT2T). Every group except control group were caused allergic rhinitis by Ovalbumin. BTT & BT2T were orally administered the Bangpungtongsungsan for 21days. Since then we observed the liver tissue cell and the nasal mucous membrane. Results : In comparison with ARE, experimental groups show relief of the nasal mucous membrane damage(secretion of mucus decrease, Itching decrease), Th2 eruption control(IL-4 decline), effect of anti-inflamatory(reducing TNF-α creation, decreasing of iNOS through NF-κB activation-inhibition). In addition, experimental groups show a loss in weight, diminished accumulation of fat. (decreasing within liver tissue, reducing TNF-α creation) BT2T is more effective to BTT. Conclusion : Bangpungtongsungsan treat obese model on allergy rhinitis thereby control fat augmentation, relieving inflammation.

Abstract

Objective : For various reasons, Obesity & Rhinitis are constantly rising. So Interest of treatment has been expanding. We want to verify The Chungyeol (fire extinguishing) Lisup (Draining) effect of Bangpungtongsungsan on obese model of allergy rhinitis. Material and Methods : BALB/c mouse were divided four groups: control(CON), allergic induction(ARE), Bangpungtongsungsan extract administration(BTT), Bangpungtongsungsan double concentration extract administration (BT2T). Every group except control group were caused allergic rhinitis by Ovalbumin. BTT & BT2T were orally administered the Bangpungtongsungsan for 21days. Since then we observed the liver tissue cell and the nasal mucous membrane. Results : In comparison with ARE, experimental groups show relief of the nasal mucous membrane damage(secretion of mucus decrease, Itching decrease), Th2 eruption control(IL-4 decline), effect of anti-inflamatory(reducing TNF-α creation, decreasing of iNOS through NF-κB activation-inhibition). In addition, experimental groups show a loss in weight, diminished accumulation of fat. (decreasing within liver tissue, reducing TNF-α creation) BT2T is more effective to BTT. Conclusion : Bangpungtongsungsan treat obese model on allergy rhinitis thereby control fat augmentation, relieving inflammation.

참고문헌 (35)

  1. Rho GT, "Otolaryngology(Head and Neck Surgery)", pp.208~212 (2005), Ilchokak
  2. Borich L, "Allergic rhinitis : Systemic inflammation and implications for management", J Allergy Clin Immunol, 112(6), pp.1021~1031 (2003)
  3. Go BG, "A Study on Establishing the Korean Obesity index", J. of Korea military academy, 55(3), pp.281~407 (1999)
  4. The Korean Academy of Orietal Rehabilitation Medicine, "Oriental Rehabilitation Medicine 2nd edition", pp.384~396 (2005), koonja publishing company
  5. Huang SL, "Association between body mass index and allergy in teenage girl in taiwan", Clin Exp Allergy, 29, pp.323~329 (1999)
  6. 정혜미, "비만과 알레르기 비염의 상관성에 관한 연구", 동의생리병리학회지, 24(6), pp.1099~1104 (2010), 한의병리학회
  7. Jian L, "Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice", Nature Medicine, 15, pp.940~945 (2009)
  8. Jie Z, "Mast cell and metabolic syndrome", Biochimica et Biophsica Acta, 1822, pp.14~20 (2012)
  9. Kwang-Hyun Hwang, "Anti-obesity Effect of Berberine in Mice Fed a High Fat Diet", Preventive Nutrition and Food Science, 14(4), pp.298~302 (2009), 한국식품영양과학회
  10. Health Insurance Corporation, Health Insurance Review & Assessment Service, "2014Health Insurance Statistical Yearbook" (2014)
  11. Korean Centers for Disease Control and Prevention(The Ministry of Health and Welfare)., "2014 National Health Nutrition Investigation", ~ (2014)
  12. Rho SS, "Primary Color Ophthalmology &Otolaryngology", pp.578~583 (2013), P&B
  13. You WS, "Sunmyungbangron", pp.768~ (1988), Yeogang publishing company
  14. 김정훈, "EBM 기반구축을 위한 방풍통성산 실험 연구 분석", 한방안이비인후피부과학회지, 24(1), pp.1~15 (2011), 대한한방안이비인후피부과학회
  15. 김희정, "알러지성 비염 병태 모델에 대한 防風通聖散의 항알러지 효과", 한방안이비인후피부과학회지, 19(1), pp.21~30 (2006), 대한한방안이비인후피부과학회
  16. 정수진, "간 각질 세포 및 마우스 비장 세포를 이용한 방풍통성산의 항알러지 효능 연구", 동의생리병리학회지, 29(2), pp.168~173 (2015), 한의병리학회[DOI]
  17. 황선혜, "한국 소아의 알레르기비염 역학", Allergy Asthma & Respiratory Diseases, 1(4), pp.321~332 (2013), 대한 소아알레르기 호흡기학회
  18. 최용성, "항히스타민제의 올바른 사용법", 대한의사협회지, 56(3), pp.231~239 (2013), 대한의사협회
  19. The Korean Academy of Asthma, "Treatment Guideline For Allergic Rhinitis for Clinicians", pp.18~60 (2015), medrang
  20. Association of Oriental medicine Herbal Formula Professor, "Study of herbal formula", pp.263~264 (2003), Younglimsa
  21. 박영미, "고지방 식이로 유도된 비만 마우스에서 대두 부산물인 순물과 침지수의 항비만 효과", 한국자원식물학회지, 28(2), pp.168~177 (2015), 한국자원식물학회[DOI]
  22. Cho KH, "Studies on the Basic Data of Ktc: Balb", c AnNCrj Mice with Age: Body Weight, Organ Weight, Hematology, Serum Biochemistry, Urine Analysis and Reproductive Performance, 1998, pp.14(2), 207~213
  23. 이민정, "만성비염 환아의 수면의 질과 성장에 관한 임상적 연구", 대한한방소아과학회지, 22(2), pp.125~139 (2008), 대한한방소아과학회
  24. Lee AK, "Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-α and COX-2expression by sauchinone effectson I-κBαphosphorylation, C", EBP and AP-1 activation, 2003, pp.139, 11~20
  25. Delgado AV, "Production of tumor necrosis factor-alpha, interleukin 1-beta, interleukin 2, and interleukin 6 by rat leukocyte subpopulations after exposure to substance P", Neuropeptides, 37(6), pp.355~361 (2003)
  26. 연지영, "과체중 이상 성인에서 혈중 콜레스테롤 수준에 따른 영양소 섭취량, 혈중 산화 및 염증 관련 지표에 관한 연구", 한국식품영양학회지, 24(1), pp.1~11 (2011), 한국식품영양학회
  27. Paul WE, "Interleukin-4 : a prototypic immunoregulatory lyphokine", Blood, 77, pp.1859~1870 (1991)
  28. Gelfand EW, "Inflammatiry mediators in allergic rhinitis", J allergy Clin Immunol, 114, pp.135~138 (2004)
  29. Friedmann PS, "Pathogenesis and management of atopic dermatitis", Clin. Exp. Allergy, 25, pp.799~806 (1995)
  30. Baeuerle PA, "IκB-NF-κB structure : at the interface of inflammation control", Cell, 95, pp.729~731 (1998)
  31. Takeno S, "Nuclear factor kappa B activation in the nasal polypepithelium : relationship to local cytokinegene expression", Laryngoscope, 12(1), pp.53~58 (2002)
  32. Moncada S, "Nitric oxide:physiology, pathophysiology, and pharmacology", Pharmacol. Rev, 43, pp.109~142 (1991)
  33. Marletta MA, "Macrophage oxidation of L-arginine to nitrite and nitrate : nitric oxide is an intermediate", Biochemisry, 27, pp.8706~8711 (1988)
  34. Pfaar O, "Pathophysiology of itching and sneezing in allergic rhinitis", SWISS MED WKLY, 139(3-4), pp.35~40 (2009)
  35. Jang YC, "Time Dependent Change of Neuropeptides in Human Burn Wound Healing and Scar Formation", J. of Korean Burn Society, 6(2), pp.124~133 (2003)

관련 논문AI추천

비만 유발 생쥐에서 Th2분화조절을 통한 황련-감초 하태독법의 알레르기성 비염 발현 억제효과김기봉, 안상현, 정아람대한한방소아과학회 · 대한한방소아과학회지2019 · 제33권 제2호두시 하태독법이 시행된 비만 생쥐에서 Th2 분화조절을 통한 알러지성 비염 유발 감소 효과김기봉, 안상현대한한방소아과학회 · 대한한방소아과학회지2018 · 제32권 제2호PPAR-γ조절을 통한 麗澤通氣湯의 항알레르기와 항염증 효과손정민, 홍승욱대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2010 · 제23권 제2호알러지성 비염 병태 모델에 대한 防風通聖散의 항알러지 효과김규석, 김윤범, 김희정, 박외숙, 차재훈대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2006 · 제19권 제1호방풍통성산의 지방대사조절을 통한 비알콜성 지방간 유도 인슐린저항성 개선 효과김기봉, 서일복, 안상현대한한방소아과학회 · 대한한방소아과학회지2018 · 제32권 제4호방풍통성산이 고지방식이 유도 어린 비만 생쥐의 지방 축적에 미치는 영향김기봉, 안상현대한한방소아과학회 · 대한한방소아과학회지2024 · 제38권 제1호

이 간행물의 다른 논문 (13건)

補中益氣湯이 접촉성 과민반응에 미치는 影響박양구, 이진호, 강석훈, 윤용갑, 정명, 복영옥, 임규상pp. 16-32편백유(Chamaecyparis Obtusa Oil)가 DNCB로 유도된 NC/Nga생쥐의 아토피에 미치는 효과 연구손기정, 김윤주, 한지연, 박정환, 고가연, 김윤하, 고기태, 안택원pp. 33-46C57BL/6N 마우스 탈모모델에서 미세다륜침(MTS)과 황련해독탕 약침액 도포가 모발성장에 미치는 영향윤화정, 고우신, 강나루pp. 47-64Gagamyeonryunggobon-dan(Jiājiǎnyánlínggùběn-dān) induces hair regrowth effect from activating hair follicleYoung-Joon Yoon, Ahra Cho, 홍승욱pp. 65-80신효탁리산 함유 한방화장품의 보습 효능에 대한 임상적 연구강민서, 김희택, 김용민pp. 81-92
원문 보기