소 동물 촬영을 위한 Micro-CT의 개발
Development of a Micro-CT System for Small Animal Imaging
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
We developed an x-ray cone-beam micro computed tomography (micro-CT) system for small-animal imaging. The micro-CT system consists of a 2-D flat-panel x-ray detector with a field-of-view (FOV) of 120120 mm2, a micro-focus x-ray source, a scan controller and a parallel image reconstruction system. Imaging performances of the micro-CT system have been evaluated in terms of contrast and spatial resolution. The minimum resolvable contrast has been found to be less than 36 CT numbers at the dose of 95 mGy and the spatial resolution about 14 lp/mm. As small animal imaging results, we present high resolution 3-D images of rat organs including a femur, a heart and vessels. We expected that the developed micro-CT system can be greatly used in biomedical studies using small animals.
Abstract
We developed an x-ray cone-beam micro computed tomography (micro-CT) system for small-animal imaging. The micro-CT system consists of a 2-D flat-panel x-ray detector with a field-of-view (FOV) of 120120 mm2, a micro-focus x-ray source, a scan controller and a parallel image reconstruction system. Imaging performances of the micro-CT system have been evaluated in terms of contrast and spatial resolution. The minimum resolvable contrast has been found to be less than 36 CT numbers at the dose of 95 mGy and the spatial resolution about 14 lp/mm. As small animal imaging results, we present high resolution 3-D images of rat organs including a femur, a heart and vessels. We expected that the developed micro-CT system can be greatly used in biomedical studies using small animals.
참고문헌 (20)
- "Molecular imaging in living subject:seeing fundamental biological processes in a new light", 17, pp.545~580 (2003)
- "Molecular imaging:an overview", 8, pp.1141~1153 (2001)
- "Molecular imaging", 219, pp.316~333 (2001)
- "Three-dimensional imaging of vasculature and parenchyma in intact rodent organs with x-ray micro-CT", 275, pp.H1103~1114 (1998)
- "A new x-ray computed tomography system for laboratory mouse imaging", 46, pp.558~564 (1999)
- "Extraction of the hepatic vasculature in rats using 3-D micro-CT images", 19, pp.964~971 (2000)
- "High-resolution x-ray CT screening of mutant mouse models", 3921, pp.270~279 (2000)
- "Molecular imaging in small animals-roles for micro-CT", 39, pp.116~124 (2002)
- "A high-resolution XRII-based quantitative volume CT scanner", 20, pp.449~462 (1993)
- "Micro-CT scanners for biomedical applications:an overview", 16, pp.18~27 (2001)
- "A simple method for determining the modulation transfer function in digital radiography", 11, pp.34~39 (1992)
- "^A flat-panel detector based micro-CT system:performance evaluation for small-animal imaging", 48, pp.4173~4185 (2003)
- "Performance comparison of reconstruction algorithms for fan-beam computerized tomography", 22, pp.223~229 (2001)
- "Practical cone-beam algorithm", 1, pp.612~619 (1984)
- "Imaging modality in x-ray computerized tomography and in selected volume tomography", 44, pp.~56 (1999)
- "Distributed image reconstruction for an in-vivo mouse imaging system", 5030, pp.639~646 (2003)
- "Handbook of Medical Imaging", pp, pp.1~78 (2000), SPIE Press
- "Three dimensional reconstructions from radiographs and electron micrographs:application of convolution instead of Fourier transforms", 68, pp.2236~2240 (1971)
- "Determination of the presampled MTF in computed tomography", 28, pp.356~360 (2001)
- "Determination of the presampled MTF in computed tomography", 28, pp.356~360 (2001)