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특발성 파킨슨병 환자의 완서증 정량화를 위한 전완 내회전/외회전 운동의 각속도 측정

Measurement of Angular Velocity of Forearm Pronation/Supination Movement for the Quantification of the Bradykinesia in Idiopathic Parkinson's Disease Patients

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초록

The purpose of this study is to investigate the angular velocity of forearm pronation/supination movement in Parkinson's disease patients, as a quantitative measure of the bradykinesia. Thirteen Parkinson's disease patients (64 ± 11.0 yrs, male:6, female:7) participated in the experiments. The subjects' both right and left forearms were scored by a rater according to rapid alternating movement of hands category in the UPDRS (unified Parkinson's disease rating scale) and the angular velocity of forearm pronation/supination was measured at the same time. As analysis parameters, RMS (root mean square) angular velocity and RMS angle were used. The parameters showed negative correlation with the clinical score (RMS angular velocity: r=–0.914, RMS angle: r=–0.749). The RMS angular velocity of all clinical scales were significantly different one another except for the non significant difference between those of scale 3 and 4. RMS angle of scale 0 was significantly different from those of scale 2, 3, 4 and that of scale 1 was significantly different from those of scale 3 and 4. This suggests that RMS angular velocity can be used for a quantitative measure of bradykinesia in motor examination.

Abstract

The purpose of this study is to investigate the angular velocity of forearm pronation/supination movement in Parkinson's disease patients, as a quantitative measure of the bradykinesia. Thirteen Parkinson's disease patients (64 ± 11.0 yrs, male:6, female:7) participated in the experiments. The subjects' both right and left forearms were scored by a rater according to rapid alternating movement of hands category in the UPDRS (unified Parkinson's disease rating scale) and the angular velocity of forearm pronation/supination was measured at the same time. As analysis parameters, RMS (root mean square) angular velocity and RMS angle were used. The parameters showed negative correlation with the clinical score (RMS angular velocity: r=–0.914, RMS angle: r=–0.749). The RMS angular velocity of all clinical scales were significantly different one another except for the non significant difference between those of scale 3 and 4. RMS angle of scale 0 was significantly different from those of scale 2, 3, 4 and that of scale 1 was significantly different from those of scale 3 and 4. This suggests that RMS angular velocity can be used for a quantitative measure of bradykinesia in motor examination.

참고문헌 (8)

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  3. A. L. Taylor Tavares, "Quantitative measurements of alternating finger tapping in Parkinson's disease correlate with UPDRS motor disability and reveal the improvement in fine motor control from medication and deep brain stimulation", Mov Disord, 20(10), pp.1286~1298 (2005)
  4. R. Okuno, "Measurement system of finger-tapping contact force for quantitative diagnosis of Parkinson's disease", Proc. 29th IEEE Eng Med Biol Soc, pp.1354~1357 (2007)
  5. D. P. Allen, "On the use of low-cost computer peripherals for the assessment of motor dysfunction in Parkinson's disease--quantification of bradykinesia using target tracking tasks", IEEE Trans Neural Syst Rehabil Eng, 15(2), pp.286~294 (2007)
  6. A. Jobbagy, "Analysis of finger-tapping movement", J Neurosci Methods, 141(1), pp.29~39 (2005)
  7. M. L. Latash, "Neurophysiological Basis of Movement", pp.221~226 (2007), Humam Kinetics
  8. 김지원, "파킨슨씨 병 환자와 정상인의 입각기시간과 상비율의 비교", 의공학회지, 27(6), pp.351~356 (2006), 대한의용생체공학회

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