파킨슨성 완서증의 손가락 마주치기 속도와 크기에 대한 약물과 뇌심부자극의 효과
Effects of Medication and Deep Brain Stimulation on the Finger-tapping Speed and Amplitude of Parkinsonian Bradykinesia
0
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
The purpose of this study is to investigate whether medication and deep brain stimulation (DBS) have differential effects on the speed and amplitude of bradykinesia in patients with Parkinson's disease (PD). Five PD patients with implanted DBS electrodes (age: 60.6 ± 7.4 yrs, H&Y stage: 3.1 ± 0.2) participated in this study. FT (finger tapping) movement was measured using a gyrosensor system in four treatment conditions: Med (Medication)-off/DBS-off, Med-off/DBS-on, Med-on/DBS-off and Med-on/DBS-on. Quantitative measures representing average speed and amplitude of FT movement included root-mean-squared (RMS) angular velocity and RMS angle. One-way repeated measures ANOVA showed that RMS angular velocity of Med-on/DBS-on was significantly greater than those of Med-off/DBS-off and Med-off/DBS-on (p < 0.01) whereas RMS angle was not different among conditions (p = 0.06). Two way repeated measures ANOVA showed that only medication improved RMS angular velocity (p < 0.01), whereas both medication and DBS had no significant effect on RMS angle (p > 0.02). Effect size of RMS angular velocity was greater than that of RMS angle in both medication and DBS. This suggests that medication and DBS have differential effects on FT bradykinesia and velocity and amplitude impairments may be associated with different functional aspects in PD.
Abstract
The purpose of this study is to investigate whether medication and deep brain stimulation (DBS) have differential effects on the speed and amplitude of bradykinesia in patients with Parkinson's disease (PD). Five PD patients with implanted DBS electrodes (age: 60.6 ± 7.4 yrs, H&Y stage: 3.1 ± 0.2) participated in this study. FT (finger tapping) movement was measured using a gyrosensor system in four treatment conditions: Med (Medication)-off/DBS-off, Med-off/DBS-on, Med-on/DBS-off and Med-on/DBS-on. Quantitative measures representing average speed and amplitude of FT movement included root-mean-squared (RMS) angular velocity and RMS angle. One-way repeated measures ANOVA showed that RMS angular velocity of Med-on/DBS-on was significantly greater than those of Med-off/DBS-off and Med-off/DBS-on (p < 0.01) whereas RMS angle was not different among conditions (p = 0.06). Two way repeated measures ANOVA showed that only medication improved RMS angular velocity (p < 0.01), whereas both medication and DBS had no significant effect on RMS angle (p > 0.02). Effect size of RMS angular velocity was greater than that of RMS angle in both medication and DBS. This suggests that medication and DBS have differential effects on FT bradykinesia and velocity and amplitude impairments may be associated with different functional aspects in PD.
참고문헌 (10)
- A.J. Espay, "Impairments of speed and amplitude of movement in Parkinson's disease: a pilot study", Mov Disord, 24(7), pp.1001~1008 (2009)
- A. Kandori, "Quantitative magnetic detection of finger movements in patients with Parkinson's disease", Neurosci Res, 49(2), pp.253~260 (2004)
- M. Yokoe, "Opening velocity, a novel parameter, for finger tapping test in patients with Parkinson's disease", Parkinsonism Relat Disord, 15(6), pp.440~444 (2009)
- C.G. Goetz, "Movement Disorder Society- sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results", Mov Disord, 23(15), pp.2129~2170 (2008)
- T.E. Kimber, "Voluntary movement after pallidotomy in severe Parkinson's disease", Brain, 122(Pt 5), pp.895~906 (1999)
- A.J. Espay, "Differential response of speed, amplitude, and rhythm to dopaminergic medications in Parkinson's disease", Mov Disord, 26(14), pp.2504~2508
- J.W. Kim, "Quantification of bradykinesia during clinical finger taps using a gyrosensor in patients with Parkinson's disease", Med. Biol. Eng. Comput., 49(3), pp.365~371 (2011)
- 김지원, "자이로센서를 이용한 특발성 파킨슨병 환자와 정상인의 손가락 벌렸다 오므리기 동작의 측정과 비교", 의공학회지, 31(3), pp.240~244 (2010), 대한의용생체공학회
- L. Timmermann, "Differential effects of levodopa and subthalamic nucleus deep brain stimulation on bradykinesia in Parkinson's disease", Mov Disord, 23(2), pp.218~227 (2008)
- R. Wenzelburger, "Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements", Mov Disord, 18(10), pp.1162~1169 (2003)