전기방사법으로 제조한 PU/PEG 복합 지지체의 특성
Characteristics of PU/PEG Hybrid Scaffolds Prepared by Electrospinning
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초록
Polyurethane/polyethylene glycol(PU/PEG) hybrid scaffolds with various concentrations of PEG (0 to 50wt%) were prepared by electrospinning to evaluate the mechanical properties and the biocompatibility of the PU/ PEG blend scaffolds. The 12wt% PU/PEG polymers were studied due to the absence of beads. The ultimate tensile strength of 12wt% PU was 8.2 ± 0.5 MPa. The strength increased to 9.2 ± 0.7 MPa when 10% PEG was added to PU. However, the dry and the wet strength of PU/PEG scaffolds began to decrease dramatically when the PEG content was more than 10wt%. No cytotoxicity was observed for all the PU/PEG scaffolds investigated, indicating that the PU/PEG hybrid scaffolds are clinically safe and effective to small-diameter vascular grafts. In addition, the L-929 cells attached and proliferated well on the PU/PEG hybrid scaffolds.
Abstract
Polyurethane/polyethylene glycol(PU/PEG) hybrid scaffolds with various concentrations of PEG (0 to 50wt%) were prepared by electrospinning to evaluate the mechanical properties and the biocompatibility of the PU/ PEG blend scaffolds. The 12wt% PU/PEG polymers were studied due to the absence of beads. The ultimate tensile strength of 12wt% PU was 8.2 ± 0.5 MPa. The strength increased to 9.2 ± 0.7 MPa when 10% PEG was added to PU. However, the dry and the wet strength of PU/PEG scaffolds began to decrease dramatically when the PEG content was more than 10wt%. No cytotoxicity was observed for all the PU/PEG scaffolds investigated, indicating that the PU/PEG hybrid scaffolds are clinically safe and effective to small-diameter vascular grafts. In addition, the L-929 cells attached and proliferated well on the PU/PEG hybrid scaffolds.
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