약물지연방출을 위한 스테레오컴플렉스 PLA 원반형 마이크로입자
Stereocomplex Poly(lactic acid) Discoidal Microparticles for Sustained Drug Release
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초록
Controlled drug release is important for effective treatment of cancer. Poly(DL-lactide-co-glycolide) acid (PLGA) is a Food and Drug Administration (FDA) approved polymer and have been extensively studied as drug delivery carriers with biodegradable and biocompatible properties. However, PLGA drug delivery carriers are limited due to the initial burst release of drug. Certain drugs require an early rapid release, but in many cases the initial rapid release can be inefficient, reducing therapeutic effects and also increasing side effects. Therefore, sustained release is important for effective treatment. Poly Lactic Acid stereo complex (PLA SC) is resistant to hydrolysis and has high stability in aqueous solutions. Therefore, in this work, PLGA based discoidal polymeric particles are modified by Poly Lactic Acid stereocomplex (PLAsc DPPs). PLAsc DPPs are 3 μm in diameter, also showing a relatively sustained release profile. Fluorescein 5(6)-isothiocyanate (FITC) released from PLAsc DPPs was continuously observed until 38 days, which showed the initial release of FITC from PLAsc DPPs was about 3.9-fold reduced as compared to PLGA based DPPs at 1 hour.
Abstract
Controlled drug release is important for effective treatment of cancer. Poly(DL-lactide-co-glycolide) acid (PLGA) is a Food and Drug Administration (FDA) approved polymer and have been extensively studied as drug delivery carriers with biodegradable and biocompatible properties. However, PLGA drug delivery carriers are limited due to the initial burst release of drug. Certain drugs require an early rapid release, but in many cases the initial rapid release can be inefficient, reducing therapeutic effects and also increasing side effects. Therefore, sustained release is important for effective treatment. Poly Lactic Acid stereo complex (PLA SC) is resistant to hydrolysis and has high stability in aqueous solutions. Therefore, in this work, PLGA based discoidal polymeric particles are modified by Poly Lactic Acid stereocomplex (PLAsc DPPs). PLAsc DPPs are 3 μm in diameter, also showing a relatively sustained release profile. Fluorescein 5(6)-isothiocyanate (FITC) released from PLAsc DPPs was continuously observed until 38 days, which showed the initial release of FITC from PLAsc DPPs was about 3.9-fold reduced as compared to PLGA based DPPs at 1 hour.
참고문헌 (27)
- TGJr CBR, "Timeline : chemotherapy and the war on cancer", Nat Rev Cancer, 5, pp.6572~ (2005)
- Singh RP, "Chitosan-folate decorated carbon nanotubes for site specific lung cancer delivery", Materials Science and Engineering : C, 77, pp.446~458 (2017)
- Mignani S, "Advances in combination therapies based on nanoparticles for efficacious cancer treatment : an analytical report", Biomacromolecules, 16, pp.1~27 (2014)
- Pérez-Herrero E, "Advanced targeted therapies in cancer : drug nanocarriers, the future of chemotherapy", European journal of pharmaceutics and biopharmaceutics, 93, pp.52~79 (2015)
- Senapati S, "Controlled drug delivery vehicles for cancer treatment and their performance", Signal transduction and targeted therapy, 3, pp.7~ (2018)
- Witharana C, "Drug Delivery Systems : A New Frontier in Nano-technology", International Journal of Medical Research & Health Sciences, 6, pp.11~14 (2017)
- Langer R, "New methods of drug delivery", Science, 249, pp.1527~1533 (1990)
- Sonali, "Transferrin receptor-targeted vitamin E TPGS micelles for brain cancer therapy: preparation, characterization and brain distribution in rats", Drug delivery, 23, pp.1788~1798 (2016)
- Bhirde AA, "Targeted killing of cancer cells in vivo and in vitro with EGFdirected carbon nanotube-based drug delivery", ACS nano, 3, pp.307~316 (2009)
- Uhrich KE, "Polymeric systems for controlled drug release", Chemical reviews, 99, pp.3181~3198 (1999)
- Huang X, "On the importance and mechanisms of burst release in matrix-controlled drug delivery systems", Journal of controlled release, 73, pp.121~136 (2001)
- Setterstrom JA, "Recent advances in drug delivery systems", pp.185~198 (1984)
- Ulery BD, "Biomedical applications of biodegradable polymers", Journal of polymer science Part B : polymer physics, 49, pp.832~864 (2011)
- Ikada Y, "Stereocomplex formation between enantiomeric poly(lactides)", Macromolecules, 20, pp.904~906 (1987)
- Monticelli O, "New stereocomplex PLA-based fibers : effect of POSS on polymer functionalization and properties", Macromolecules, 47, pp.4718~4727 (2014)
- Regnell Andersson S, "Customizing the hydrolytic degradation rate of stereocomplex PLA through different PDLA architectures", Biomacromolecules, 13, pp.1212~1222 (2012)
- Pastorino L, "Stereocomplex poly(lactic acid)nanocoated chitosan microparticles for the sustained release of hydrophilic drugs", Materials Science and Engineering : C, 76, pp.1129~1135 (2017)
- Xie G, "Biodistribution and toxicity of intravenously administered silica nanoparticles in mice", Archives of toxicology, 84, pp.183~190 (2010)
- Sarparanta M, "Intravenous delivery of hydrophobin-functionalized porous silicon nanoparticles : stability, plasma protein adsorption and biodistribution", Molecular pharmaceutics, 9, pp.654~663 (2012)
- Almeida JPM, "In vivo biodistribution of nanoparticles", Nanomedicine, 6, pp.815~835 (2011)
- Jindal AB, "The effect of particle shape on cellular interaction and drug delivery applications of micro-and nanoparticles", International journal of pharmaceutics, 532, pp.450~465 (2017)
- Decuzzi P, "Size and shape effects in the biodistribution of intravascularly injected particles", Journal of Controlled Release, 141, pp.320~327 (2010)
- Looney MR, "Live imaging of the lung", Annual review of physiology, 76, pp.431~445 (2014)
- Yu T, "Influence of geometry, porosity and surface characteristics of silica nanoparticles on acute toxicity : their vasculature effect and tolerance threshold", ACS nano, 6, pp.2289~2301 (2012)
- Park JY, "Biodegradable micro-sized discoidal polymeric particles for lung-targeted delivery system", Biomaterials, 218, pp.119331~ (2019)[DOI]
- Mak WC, "Drug delivery into the skin by degradable particles", European journal of pharmaceutics and biopharmaceutics, 79, pp.23~27 (2011)
- Liu Y, "Novel drug delivery system of hollow mesoporous silica nanocapsules with thin shells:preparation and fluorescein isothiocyanate (FITC) release kinetics", Colloids and Surfaces B : Biointerfaces, 58, pp.180~187 (2007)