혈관 내 폐 보조장치의 압력손실 예측을 위한 모델링기법에 관한 연구

Abstract

In this paper, the correlation of preㅃ ure drop about the Newtonian and non- Newtonian fluid ￦as investigated experimentally for vibrating intravascular lung assist device (v1VLAD) and we determined correlation equation to make a Prediction about Pressure drop for designing VIVLAD. Design conditions to Predict the Pressure droP of the modules were studied through an experimental modeling before inserting the arti仇cial lung assist deVice into as veno짓15. ExperimentS were performed by distined water, glycerol/ water 1lliXed solution (4O% glycerol) of Newtonian nuids, and the bovine blood of non- Newtonian flulds. These flulds were nowed outside and parallel of hollow fiber membranes. Also we measured pressure drop according to the numbel of the fiber membranes which ware inselted into the inside diameter of shell of 3 cm, and developed the predictjon equations by curve fitting methㅇ d based on correlation between the experimental pressure drop and the frontal area or the packing density of device. The result showed that the pressure drop and the friction factor of the watel· ／glycerol mixed solution were similar to that of bovine b10od. It was showed that the water／ 卽ycerol mixed solution (40% glycerol) could be used for measuring the pressure drop and the friction factor instead of the bovine blood. Also, we could estimate the prediction equation of pressure drop and friction factor as the function of packing density at the number of hollow fibers. We obtained the rehance of the prediction equations because the pressure drㅇ p and the friction factor measured from the experiments were similar to that from the prediction equa仇on. These results may be (ised to further usefulness foT the design of VIVLAD.