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인체의 위 조직 시료에서 자기공명영상장치를 이용한 확산계수 측정에 대한 기초 연구

Ex Vivo MR Diffusion Coefficient Measurement of Human Gastric Tissue

양영일|장희경|은충기|최기승|문치웅|Roger Nana|Xiaoping P. Hu
대한의용생체공학회 (The Korea Society Of Medical & Biological Engineering)|2006.10|의공학회지 (Journal of biomedical Engineering Research)|제27권 제5호|pp. 203-209

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Abstract

The aim of this study is to investigate the feasibility of ex vivo MR diffusion tensor imaging technique in order to observe the diffusion-contrast characteristics of human gastric tissues. On normal and pathologic gastric tissues, which have been fixed in a polycarbonate plastic tube filled with 10% formalin solution, laboratory made 3D diffusion tensor Turbo FLASH pulse sequence was used to obtain high resolution MR images with voxel size of 0.5x0.5x0.5mm3 using 64x32x32mm3 field of view in conjunction with an acquisition matrix of 128x64x64. Diffusion weighted- gradient pulses were employed with b values of 0 and 600s/mm2 in 6 orientations. The sequence was implemented on a clinical 3.0-T MRI scanner(Siemens, Erlangen, Germany) with a home-made quadrature-typed birdcage Tx/Rx rf coil for small specimen. Diffusion tensor values in each pixel were calculated using linear algebra and singular value decomposition(SVD) algorithm. Apparent diffusion coefficient(ADC) and fractional anisotropy(FA) map were also obtained from diffusion tensor data to compare pixel intensities between normal and abnormal gastric tissues. The processing software was developed by authors using Visual C++(Microsoft, WA, U.S.A.) and mathematical/ statistical library of GNUwin32(Free Software Foundation).This study shows that 3D diffusion tensor Turbo FLASH sequence is useful to resolve fine micro-structures of gastric tissue and both ADC and FA values in normal gastric tissue are higher than those in abnormal tissue. Authors expect that this study also represents another possibility of gastric carcinoma detection by visualizing diffusion characteristics of proton spins in the gastric tissues.

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