Spatiotemporal Analysis of Hippocampal Long Term Potentiation Using Independent Component Analysis
0
조회
0
다운로드
0
인용
0
참고문헌
초록
Abstract
Long-term potentiation (LTP) of synaptic transmission is the most widely studied model for learning and memory. However its mechanisms are not clearly elucidated and are a subject for intense investigation. Previous attempts to decipher cellular mechanisms and network properties involved a current-source density analysis (CSDA) of the LTP from small animal hippocampus measured with a limited number of microelectrodes (typically <3), only revealing limited nature of spatiotemporal dynamics. Recent advancement in multi-electrode array (MEA) technology allows continuous and simultaneous recordings of LTP with more than 60 electrodes. However CSDA via the standard Laplacian transform is still limited due to its relatively high sensitivity toward noise, inability of resolving overlapped current sources and sinks, and its requirement for tissue conductivity values. In this study, we propose a new methodology for improved CSDA. Independent component analysis and its joint use (i.e., Joint-ICA) are applied to extract spatiotemporal components of LTP. The results show that ICA and Joint-ICA are capable of extracting independent spatiotemporal components of LTP generators. The ICs of LTP indicate the reversing roles of current sources and sinks which are associated with LTP.
참고문헌 (10)
- J. S. Taube, "Mechanisms of Long-Term Potentiation Journal of Neu- roscience", 8, pp.1645~1656 (1988)
- I. Vida, "A curent-source density analysis of the long-term potentiation in the hipocampus", 671, pp.1~11 (1995)
- U. Egert, "A novel organotypic long- term culture of the rat hipocampus on substrate-integrated multie- lectrode arays", 2, pp.29~242 (1998)
- K. Shimono, "Continuous two-dimensional curent source density analysis of electrophysiological activity in hippocampal slices", 38-40, pp.899~905 (2001)
- J. Jeong, "Aplication of Independent Component Analysis with Mixture Density Model to Localize the Brain Alpha Activity in fMRI and EG", 14, pp.170~180 (2004)
- T.-P. Jung, "Blind separation of auditory event-related brain responses into independent components", 94, pp.10979~10984 (1997)
- J. J. Christopher, "Independent component analysis for biomedical signals", 26(1), pp.15~39 (2005)
- J. Le, "Spatiotemporal analysis of hipocampal long term potentiation using independent component analysis", pp.3405~3408 (2006), in Proc. World Cong- res on Biomedical Enginering
- P. E. Kunkler, "Optical current source density analysis in hippocampal organotypic culture shows that spreading depression occurs with uniquely reversing currents", 25(15), pp.3952~3961 (2005)
- T. V. P. Bliss, "Long-lasting potentiation of synaptic transmission in the dentate gyrus of the anesthetized rabbit following stimulation of the perforant path", 232, pp.331~356 (1973)