알츠하이머병과 기억성 경도인지장애에서 시계 그리기 검사의 양적 분석 및 오류 유형 분석
Quantitative and Qualitative Analyses of Clock Drawings in Patients with Alzheimer’s Disease and Amnestic Mild Cognitive Impairment
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Background: The Clock Drawing Test (CDT) has been widely used as the neuropsychological instrument to assess the cognitive function in patients with dementia. Amnestic mild cognitive impairment (aMCI) among the subtypes of MCI has a high risk of progression to Alzheimer’s disease (AD). To date, there have been few studies examining the CDT in MCI, in particular compared with AD. The purpose of this study was to compare the performance of CDT in patients with AD and aMCI. Methods: Thirty-four patients with AD and 35 patients with aMCI were participated in this study. The score of CDT was analyzed by three different methods (modified Shulman, Rouleau, and Freedman) and qualitative analyses of CDT were also performed. Results:The results of CDT showed significantly lower performances in the AD group than in the aMCI group according to the three different scoring methods. Qualitative analyses revealed that the ‘conceptual deficit’ error was useful in differentiating between the AD and aMCI groups (p<0.001). Conclusions: The patients with AD had significantly lower performances in CDT than that of the aMCI group. These results suggest that the quantatitive and qualitative analysis of the CDT can help differentiate the patients with AD from the patients with aMCI.
Abstract
Background: The Clock Drawing Test (CDT) has been widely used as the neuropsychological instrument to assess the cognitive function in patients with dementia. Amnestic mild cognitive impairment (aMCI) among the subtypes of MCI has a high risk of progression to Alzheimer’s disease (AD). To date, there have been few studies examining the CDT in MCI, in particular compared with AD. The purpose of this study was to compare the performance of CDT in patients with AD and aMCI. Methods: Thirty-four patients with AD and 35 patients with aMCI were participated in this study. The score of CDT was analyzed by three different methods (modified Shulman, Rouleau, and Freedman) and qualitative analyses of CDT were also performed. Results:The results of CDT showed significantly lower performances in the AD group than in the aMCI group according to the three different scoring methods. Qualitative analyses revealed that the ‘conceptual deficit’ error was useful in differentiating between the AD and aMCI groups (p<0.001). Conclusions: The patients with AD had significantly lower performances in CDT than that of the aMCI group. These results suggest that the quantatitive and qualitative analysis of the CDT can help differentiate the patients with AD from the patients with aMCI.
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