알츠하이머병과 경도인지장애환자에서 K-MMSE와 시계그리기 동시 수행에 대한 예비연구
The Combination of the Korean Version of Mini-Mental Status Examination and Clock Drawing Test in the Alzheimer’s Disease and Mild Cognitive Impairment: Preliminary Study
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Background: Korean version of Mini-Mental Status Examination (K-MMSE) and Clock Drawing Test (CDT) have been widely used as quick neuropsychological tests to screen for dementia in various clinical settings. We aimed to assess the diagnostic validity of the fusion of the two tests in Alzheimer dementia (AD) and mild cognitive impairment (MCI). Methods: A total of 91 subjects (33 AD, 24 MCI, 34 controls) who visited the neurology outpatient clinic of Seoul Medical Center were included. The receiver operating characteristic (ROC) curve was used to determine optimal cut-off score, sensitivity, and specificity in screening AD and MCI. Results: K-MMSE plus CDT and K-MMSE only showed the similar area under the curve (AUC), sensitivity, and specificity for the diagnosis of AD. The AUC, sensitivity, and specificity for K-MMSE plus CDT were 0.906, 91%, and 82% and for K-MMSE were 0.894, 85%, and 79%, respectively. The difference of AUC was not statistically significant. In addition, this combination showed poor utility in MCI. Conclusions: This study has failed to show any superiority of the combination of K-MMSE plus CDT over K-MMSE only in diagnosis of Alzheimer dementia.
Abstract
Background: Korean version of Mini-Mental Status Examination (K-MMSE) and Clock Drawing Test (CDT) have been widely used as quick neuropsychological tests to screen for dementia in various clinical settings. We aimed to assess the diagnostic validity of the fusion of the two tests in Alzheimer dementia (AD) and mild cognitive impairment (MCI). Methods: A total of 91 subjects (33 AD, 24 MCI, 34 controls) who visited the neurology outpatient clinic of Seoul Medical Center were included. The receiver operating characteristic (ROC) curve was used to determine optimal cut-off score, sensitivity, and specificity in screening AD and MCI. Results: K-MMSE plus CDT and K-MMSE only showed the similar area under the curve (AUC), sensitivity, and specificity for the diagnosis of AD. The AUC, sensitivity, and specificity for K-MMSE plus CDT were 0.906, 91%, and 82% and for K-MMSE were 0.894, 85%, and 79%, respectively. The difference of AUC was not statistically significant. In addition, this combination showed poor utility in MCI. Conclusions: This study has failed to show any superiority of the combination of K-MMSE plus CDT over K-MMSE only in diagnosis of Alzheimer dementia.
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