Relationships between [ 18 F]-THK5351 Retention and Language Functions in Primary Progressive Aphasia
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Background and Purpose Tere are three distinct subtypes of primary progressive aphasia (PPA): the nonfuent/agrammatic variant (nfvPPA), the semantic variant (svPPA), and the logopenic variant (lvPPA). We sought to characterize the pattern of [ 18 F]-THK5351 retention across all three subtypes and determine the topography of [ 18 F]-THK5351 retention correlated with each neurolinguistic score. Methods We enrolled 50 participants, comprising 13 PPA patients (3 nfvPPA, 5 svPPA, and 5 lvPPA) and 37 subjects with normal cognition (NC) who underwent 3.0-tesla magnetic resonance imaging, [ 18 F]-THK5351 positron-emission tomography scans, and detailed neuropsychological tests. Te PPA patients additionally participated in extensive neurolinguistic tests. Voxel-wise and region-of-interest-based analyses were performed to analyze [ 18 F]-THK5351 retention. Results Te nfvPPA patients exhibited higher [ 18 F]-THK5351 retention in the the lef inferior frontal and precentral gyri. In svPPA patients, [ 18 F]-THK5351 retention was elevated in the anteroinferior and lateral temporal cortices compared to the NC group (lef>right). Te lvPPA patients exhibited predominant [ 18 F]-THK5351 retention in the inferior parietal, lateral temporal, and dorsolateral prefrontal cortices, and the precuneus (lef>right). [ 18 F]-THK5351 retention in the lef inferior frontal area was associated with lower fuency scores. Comprehension was correlated with [ 18 F]-THK5351 retention in the lef temporal cortices. Repetition was associated with [ 18 F]-THK5351 retention in the lef inferior parietal and posterior temporal areas, while naming difculty was correlated with retention in the lef fusiform and temporal cortices. Conclusions Te pattern of [ 18 F]-THK5351 retention was well matched with clinical and radiological fndings for each PPA subtype, in agreement with the anatomical and functional location of each language domain.
Abstract
Background and Purpose Tere are three distinct subtypes of primary progressive aphasia (PPA): the nonfuent/agrammatic variant (nfvPPA), the semantic variant (svPPA), and the logopenic variant (lvPPA). We sought to characterize the pattern of [ 18 F]-THK5351 retention across all three subtypes and determine the topography of [ 18 F]-THK5351 retention correlated with each neurolinguistic score. Methods We enrolled 50 participants, comprising 13 PPA patients (3 nfvPPA, 5 svPPA, and 5 lvPPA) and 37 subjects with normal cognition (NC) who underwent 3.0-tesla magnetic resonance imaging, [ 18 F]-THK5351 positron-emission tomography scans, and detailed neuropsychological tests. Te PPA patients additionally participated in extensive neurolinguistic tests. Voxel-wise and region-of-interest-based analyses were performed to analyze [ 18 F]-THK5351 retention. Results Te nfvPPA patients exhibited higher [ 18 F]-THK5351 retention in the the lef inferior frontal and precentral gyri. In svPPA patients, [ 18 F]-THK5351 retention was elevated in the anteroinferior and lateral temporal cortices compared to the NC group (lef>right). Te lvPPA patients exhibited predominant [ 18 F]-THK5351 retention in the inferior parietal, lateral temporal, and dorsolateral prefrontal cortices, and the precuneus (lef>right). [ 18 F]-THK5351 retention in the lef inferior frontal area was associated with lower fuency scores. Comprehension was correlated with [ 18 F]-THK5351 retention in the lef temporal cortices. Repetition was associated with [ 18 F]-THK5351 retention in the lef inferior parietal and posterior temporal areas, while naming difculty was correlated with retention in the lef fusiform and temporal cortices. Conclusions Te pattern of [ 18 F]-THK5351 retention was well matched with clinical and radiological fndings for each PPA subtype, in agreement with the anatomical and functional location of each language domain.
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