Effect of Paper-Based Cognitive Training in Early Stage of Alzheimer's Dementia
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Background and Purpose: Cognitive training refers to a series of standardized tasks with inherent challenges that target specific cognitive domains. Positive outcome of cognitive training in persons with Alzheimer's disease has been reported. In this study, the objective was to design sets of cognitive training program, “Gipum-seo” which is combined cognitive training, consists of different levels of difficulty using predesigned paper-and-pencil exercises. Also, to evaluate the effects of the cognitive training on patients' with early stage of Alzheimer's disease. Methods: The subjects for this study were forty participants who were diagnosed with early stage of Alzheimer's dementia. To test the efficacy of paper-based cognitive training programs to cognition, all patients were randomly grouped to either an intervention group ( n =20) or a control group ( n =20). The intervention group regularly received 24 sessions of paper-based cognitive training over a 12-week period. Neuropsychological examinations were conducted before and after this training period. Results: After the 12 weeks, the intervention group showed a significant change in Korean version of the Mini-Mental State Examination (25.90±3.8), compared to the control group (23.7±2.8) ( p =0.042). The training group also showed a significant improvement in language, attention and executive function, as compared with controls. Conclusions: Paper-based cognitive training might have beneficial effects on the general cognitive functions in the early stage of Alzheimer's dementia.
Abstract
Background and Purpose: Cognitive training refers to a series of standardized tasks with inherent challenges that target specific cognitive domains. Positive outcome of cognitive training in persons with Alzheimer's disease has been reported. In this study, the objective was to design sets of cognitive training program, “Gipum-seo” which is combined cognitive training, consists of different levels of difficulty using predesigned paper-and-pencil exercises. Also, to evaluate the effects of the cognitive training on patients' with early stage of Alzheimer's disease. Methods: The subjects for this study were forty participants who were diagnosed with early stage of Alzheimer's dementia. To test the efficacy of paper-based cognitive training programs to cognition, all patients were randomly grouped to either an intervention group ( n =20) or a control group ( n =20). The intervention group regularly received 24 sessions of paper-based cognitive training over a 12-week period. Neuropsychological examinations were conducted before and after this training period. Results: After the 12 weeks, the intervention group showed a significant change in Korean version of the Mini-Mental State Examination (25.90±3.8), compared to the control group (23.7±2.8) ( p =0.042). The training group also showed a significant improvement in language, attention and executive function, as compared with controls. Conclusions: Paper-based cognitive training might have beneficial effects on the general cognitive functions in the early stage of Alzheimer's dementia.
참고문헌 (25)
- Livingston G, "Dementia prevention, intervention, and care", Lancet, 390, pp.2673~2734 (2017)
- Prince M, "The global prevalence of dementia: a systematic review and metaanalysis", Alzheimers Dement, 9, pp.63~75.e2 (2013)
- Karakaya T, "Pharmacological treatment of mild cognitive impairment as a prodromal syndrome of Alzheimer's disease", Curr Neuropharmacol, 11, pp.102~108 (2013)
- Muayqil T, "Systematic review and meta-analysis of combination therapy with cholinesterase inhibitors and memantine in Alzheimer's disease and other dementias", Dement Geriatr Cogn Dis Extra, 2, pp.546~572 (2012)
- Buschert V, "Cognitive intervention in Alzheimer disease", Nat Rev Neurol, 6, pp.508~517 (2010)
- García-Casal JA, "Computer-based cognitive interventions for people living with dementia: a systematic literature review and meta-analysis", Aging Ment Health, 21, pp.454~467 (2017)
- Clare L, "Cognitive rehabilitation and cognitive training for early-stage Alzheimer's disease and vascular dementia", Cochrane Database Syst Rev (2003)
- Belleville S, "Training-related brain plasticity in subjects at risk of developing Alzheimer's disease", Brain, 134, pp.1623~1634 (2011)
- Spironelli C, "Functional plasticity in Alzheimer's disease: effect of cognitive training on language-related ERP components", Neuropsychologia, 51, pp.1638~1648 (2013)
- Kallio EL, "Cognitive training interventions for patients with Alzheimer's disease: a systematic review", J Alzheimers Dis, 56, pp.1349~1372 (2017)
- 양영순, "Improvement of Cognitive Function after Computer-Based Cognitive Training in Early Stage of Alzheimer’s Dementia", Dementia and Neurocognitive Disorders(대한치매학회지), 16(1), pp.7~11 (2017), 대한치매학회[DOI]
- Jelcic N, "Effects of lexical-semantic treatment on memory in early Alzheimer disease: an observer-blinded randomized controlled trial", Neurorehabil Neural Repair, 26, pp.949~956 (2012)
- Shao YK, "Computer-based cognitive programs for improvement of memory, processing speed and executive function during age-related cognitive decline: a meta-analysis", PLoS One, 10, pp.e0130831~ (2015)
- Tsolaki M, "Computer-based cognitive training versus paper and pencil training: which is more effective? A randomized controlled trial in people with mild cognitive impairment", JSM Alzheimers Dis Relat Dement, 4, pp.1032~ (2017)
- McKhann G, "Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease", Neurology, 34, pp.939~944 (1984)
- Morris JC, "Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type", Int Psychogeriatr, 9(Suppl 1), pp.173~176 (1997)
- Han C, "An adaptation of the Korean mini-mental state examination (K-MMSE) in elderly Koreans: demographic influence and population-based norms (the AGE study)", Arch Gerontol Geriatr, 47, pp.302~310 (2008)
- Kang YW, "Seoul Neuropsychological Screening Battery", Human Brain Research & Consulting Co, ~ (2003)
- Kim H, "Normative data on the Korean version of the Boston Naming Test", J Clin Exp Neuropsychol, 21, pp.127~133 (1999)
- Fastenau PS, "Adult norms for the Rey-Osterrieth Complex Figure Test and for supplemental recognition and matching trials from the Extended Complex Figure Test", Clin Neuropsychol, 13, pp.30~47 (1999)
- Kang YW, "A normative study of the Korean version of Controlled Oral Word Association Test (COWAT) in elderly", Korean J Clin Psychol, 19, pp.385~392 (2000)
- Lee JH, "Efficiencies of stroop interference indexes in healthy older adults and dementia patients", Korean J Clin Psychol, 19, pp.807~818 (2000)
- 황혜란, "The Effect of Cognitive Training in Patients with Mild Cognitive Impairment and Early Alzheimer’s Disease: A Preliminary Study", Journal of Clinical Neurology, 8(3), pp.190~197 (2012), 대한신경과학회[DOI]
- Cavallo M, "Computerized structured cognitive training in patients affected by early-stage Alzheimer's disease is feasible and effective: a randomized controlled study", Arch Clin Neuropsychol (2016)
- Li B, "Combined cognitive training vs. memory strategy training in healthy older adults", Front Psychol, 7, pp.834~ (2016)