3차원 지지체 제작을 위한 다중 분사체 노즐 바이오프린팅 시스템 개발
Development of a Multi-nozzle Bioprinting System for 3D Scaffold Fabrication
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초록
The aim of this study was to develop a multi-nozzle based bioprinting system for fabrication of threedimensional (3D) biological structure. In this study, a thermoplastic biomaterial that has relatively high mechanical stability, polycaprolactone (PCL) was used to make the 3D structure. A multi-nozzle bioprinting system was designed to dispense thermoplastic biomaterial and hydrogel simultaneously. The system that consists of 3-axes of x-y-z motion control stage and a compartment for injection syringe control mounted on the stage has been developed. Also, it has 1-axis actuator for position change of nozzle. The controllability of the printed line width with PCL was tested as a representative performance index.
Abstract
The aim of this study was to develop a multi-nozzle based bioprinting system for fabrication of threedimensional (3D) biological structure. In this study, a thermoplastic biomaterial that has relatively high mechanical stability, polycaprolactone (PCL) was used to make the 3D structure. A multi-nozzle bioprinting system was designed to dispense thermoplastic biomaterial and hydrogel simultaneously. The system that consists of 3-axes of x-y-z motion control stage and a compartment for injection syringe control mounted on the stage has been developed. Also, it has 1-axis actuator for position change of nozzle. The controllability of the printed line width with PCL was tested as a representative performance index.
참고문헌 (9)
- W. D. Kim, "3D Bioprinting Technologies for Custom Fabrication of Tissue Scaffold", Bioin Special Zine, 21 (2011)
- Biomedical Polymer Materials, "K. H. Kim", KISTI, ~ (2007)
- N. E. Fedorovich, "Evaluation of photocrosslinked Lutrol hydrogel for tissue printing applications", Biomacromolecules, 10, pp.1689~1696 (2009)
- N. E. Fedorovich, "Three-dimensional fiber deposition of cellladen, viable, patterned constructs for bone tissue printing", Tissue Eng, 14, pp.127~133 (2008)
- N. E. Fedorovich, "Biofabrication of osteochondral tissue equivalents by printing topologically defined, cell-laden hydrogel scaffolds", Tissue Eng, 18, pp.33~44 (2012)
- R. Censi, "A printable photopolymerizable thermosensitive(HPMAm-lactage)-PEG hydrogel for tissue engineering", Adv. Funct. Mater, 21, pp.1833~1842 (2011)
- Boland T., "Application of inkjet printing to tissue engineering", Biotechnol J, 1, pp.910~917 (2006)
- Maher P. S., "Characterisation of rapid prototyping techniques for studies in cell behavior", Rapid Prototyping Journal, 16, pp.116~123 (2010)
- Jakab K., "Tissue engineering by self-assembly and bioprinting of living cells", Biofabrication, 2, pp.022001~ (2010)