생체 의료 적용을 위한 3D 프린팅 지지체 제작 및 표면 최적화 기술
Surface Functionalization of Three-Dimensional Printed Scaffold for Biomedical Application
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Three-dimensional (3D) printing is one of the most effective scaffold manufacturing tech- niques which might revolutionize the realm of tissue engineering and regenerative medicine. The scaffolds, one of the major elements of tissue engineering, along with growth factors and cells, are still one of the most promising approaches for developing organ regeneration. How- ever, the applications of 3D-printed hard scaffolds might have limitations due to their poor surface properties, which play a crucial role in cell recruitment and infiltration, tissue-scaffold integration, and anti-inflammatory properties. Various prerequisites have been suggested for clinical applications of 3D-printed substitute for human body. Consequently, continuous amendment has been made to modify the surface properties, porosities and mechanical prop- erties of these scaffolds. The techniques that modify the surfaces through chemical and mate- rial modifications can also be applied to facilitate the efficacy of these scaffolds. In this re- view, we summarized the characteristics of 3D printing technology and discuss the development direction of the latest 3D printing technology toward meeting the unmet needs in the clinic.
Abstract
Three-dimensional (3D) printing is one of the most effective scaffold manufacturing tech- niques which might revolutionize the realm of tissue engineering and regenerative medicine. The scaffolds, one of the major elements of tissue engineering, along with growth factors and cells, are still one of the most promising approaches for developing organ regeneration. How- ever, the applications of 3D-printed hard scaffolds might have limitations due to their poor surface properties, which play a crucial role in cell recruitment and infiltration, tissue-scaffold integration, and anti-inflammatory properties. Various prerequisites have been suggested for clinical applications of 3D-printed substitute for human body. Consequently, continuous amendment has been made to modify the surface properties, porosities and mechanical prop- erties of these scaffolds. The techniques that modify the surfaces through chemical and mate- rial modifications can also be applied to facilitate the efficacy of these scaffolds. In this re- view, we summarized the characteristics of 3D printing technology and discuss the development direction of the latest 3D printing technology toward meeting the unmet needs in the clinic.