Effect of Integrated Cognitive Intervention Therapy in Patients with Mild to Moderate Alzheimer's Disease
1
조회
0
다운로드
5
인용
0
참고문헌
키워드
초록
Background and Purpose: The effect of the integrated program comprising cognitive training, art therapy, and music therapy has not been extensively studied in patients with Alzheimer's disease (AD). The present study investigated the effect of integrated cognitive intervention therapy on cognition, and activity of daily life (ADL), and mood in patients with mild to moderate AD. Methods: In this study, the data of 59 patients who met the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer disease and Related Disorders Association (NINCDS-ADRDS) criteria of probable AD among those who registered at the Centenarian's Good Memory Program in Goyang from September 2014 to August 2019 were collected. We statistically analyzed the scores of Korean version of a Mini-Mental Status Examination (K-MMSE), Korean Dementia Screening Questionnaire-Cognition (KDSQ-C), Geriatric Depression Scale (GDS), Beck Anxiety Inventory (BAI), and Seoul-Instrumental Activities of Daily Living (S-IADL) of the same patients before and after the use of integrated cognitive intervention therapy. Results: K-MMSE slightly increased from 18.7±4.5 to 19.7±5.0 (p<0.001) and KDSQ-C improved from 14.5±7.6 before therapy to 12.6±7.2 after therapy (p=0.001). Mean S-IADL score improved from 17.6±7.6 before therapy to 15.7±9.5 after therapy (p<0.001). Additionally, mean GDS score before the therapy was 5.6±3.5 that improved to 4.2±3.0 after the therapy (p<0.001). Mean BAI score decreased from 8.4±10.3 before therapy to 5.9±8.4 after therapy (p=0.001). Conclusions: In conclusion, this study demonstrated the possibility that the use of an integrated cognitive therapy improved cognition, ADL, and mood (depression and anxiety) in patients with mild to moderate ADs.
Abstract
Background and Purpose: The effect of the integrated program comprising cognitive training, art therapy, and music therapy has not been extensively studied in patients with Alzheimer's disease (AD). The present study investigated the effect of integrated cognitive intervention therapy on cognition, and activity of daily life (ADL), and mood in patients with mild to moderate AD. Methods: In this study, the data of 59 patients who met the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer disease and Related Disorders Association (NINCDS-ADRDS) criteria of probable AD among those who registered at the Centenarian's Good Memory Program in Goyang from September 2014 to August 2019 were collected. We statistically analyzed the scores of Korean version of a Mini-Mental Status Examination (K-MMSE), Korean Dementia Screening Questionnaire-Cognition (KDSQ-C), Geriatric Depression Scale (GDS), Beck Anxiety Inventory (BAI), and Seoul-Instrumental Activities of Daily Living (S-IADL) of the same patients before and after the use of integrated cognitive intervention therapy. Results: K-MMSE slightly increased from 18.7±4.5 to 19.7±5.0 (p<0.001) and KDSQ-C improved from 14.5±7.6 before therapy to 12.6±7.2 after therapy (p=0.001). Mean S-IADL score improved from 17.6±7.6 before therapy to 15.7±9.5 after therapy (p<0.001). Additionally, mean GDS score before the therapy was 5.6±3.5 that improved to 4.2±3.0 after the therapy (p<0.001). Mean BAI score decreased from 8.4±10.3 before therapy to 5.9±8.4 after therapy (p=0.001). Conclusions: In conclusion, this study demonstrated the possibility that the use of an integrated cognitive therapy improved cognition, ADL, and mood (depression and anxiety) in patients with mild to moderate ADs.
참고문헌 (25)
- Wimo A, "The worldwide costs of dementia 2015 and comparisons with 2010", Alzheimers Dement, 13, pp.1~7 (2017)
- Lyketsos CG, "Depression in Alzheimer's disease : overview and treatment", Biol Psychiatry, 52, pp.243~252 (2002)
- Ferretti L, "Anxiety and Alzheimer's disease", J Geriatr Psychiatry Neurol, 14, pp.52~58 (2001)
- Bianchetti A, "Pharmacological treatment of Alzheimer's disease", Aging Clin Exp Res, 18, pp.158~162 (2006)
- Schneider LS, "Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease", N Engl J Med, 355, pp.1525~1538 (2006)
- Tannenbaum C, "Reduction of inappropriate benzodiazepine prescriptions among older adults through direct patient education : the EMPOWER cluster randomized trial", JAMA Intern Med, 174, pp.890~898 (2014)
- Chancellor B, "Art therapy for Alzheimer's disease and other dementias", J Alzheimers Dis, 39, pp.1~11 (2014)
- Im ML, "Effects of art and music therapy on depression and cognitive function of the elderly", Technol Health Care, 22, pp.453~458 (2014)
- Choi AN, "Effects of group music intervention on behavioral and psychological symptoms in patients with dementia : a pilot-controlled trial", Int J Neurosci, 119, pp.471~481 (2009)
- Suzuki M, "Behavioral and endocrinological evaluation of music therapy for elderly patients with dementia", Nurs Health Sci, 6, pp.11~18 (2004)
- Vink AC, "The effect of music therapy compared with general recreational activities in reducing agitation in people with dementia : a randomised controlled trial", Int J Geriatr Psychiatry, 28, pp.1031~1038 (2013)
- Wall M, "The effects of music therapy for older people with dementia", Br J Nurs, 19, pp.108~113 (2010)
- Zhang Y, "Does music therapy enhance behavioral and cognitive function in elderly dementia patients? A systematic review and meta-analysis", Ageing Res Rev, 35, pp.1~11 (2017)
- 한현정, "인지기능이 저하된 환자에서 그룹 음악치료가 정서 및 일상생활능력에 미치는 영향", Dementia and Neurocognitive Disorders(대한치매학회지), 13(4), pp.107~111 (2014), 대한치매학회[DOI]
- Rusted J, "A multi-centre randomized control group trial on the use of art therapy for older people with dementia", Group Anal, 39, pp.517~536 (2006)
- Carrion C, "Cognitive therapy for dementia patients : a systematic review", Dement Geriatr Cogn Disord, 46, pp.1~26 (2018)
- McKhann G, "Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease", Neurology, 34, pp.939~944 (1984)
- 강성훈, "The Cortical Neuroanatomy Related to Specific Neuropsychological Deficits in Alzheimer's Continuum", Dementia and Neurocognitive Disorders(대한치매학회지), 18(3), pp.77~95 (2019), 대한치매학회[DOI]
- 양동원, "Korean Dementia Screeing Questionnaire (KDSQ)의 개발과 타당도 및 신뢰도의 평가", 대한신경과학회지, 20(2), pp.135~141 (2002), 대한신경과학회
- Yesavage JA, "Development and validation of a geriatric depression screening scale: a preliminary report", J Psychiatr Res, 17, pp.37~49 (1982)
- Beck AT, "An inventory for measuring clinical anxiety : psychometric properties", J Consult Clin Psychol, 56, pp.893~897 (1988)
- 구형모, "일상활동평가-복합(Seoul-Instrumental Activities of Daily Living ; S-IADL)의 신뢰도 및 타당도 연구", 신경정신의학, 43(2), pp.189~199 (2004), 대한신경정신의학회
- "A longitudinal follow-up of 550 mild cognitive impairment patients: evidence for large conversion to dementia rates and detection of major risk factors involved", J Alzheimers Dis, 43, pp.335~ (2015)
- Yaffe K, "Systematic Multi-Domain Alzheimer's Risk Reduction Trial(SMARRT) : study protocol", J Alzheimers Dis, 70, pp.S207~S220 (2019)
- Train the Brain Consortium, "Randomized trial on the effects of a combined physical", cognitive training in aged MCI subjects : the Train the Brain study, 2017, pp.7, 39471~