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투명 및 불투명 초음파 트랜스듀서의 음향학적 동등성 검증 : 정량적 분석 연구

Validation of Acoustic Equivalence of Transparent and Opaque Ultrasound Transducers: A Quantitative Analysis Study

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초록

Ultrasound technology is being integrated with optical systems in biomedical, industrial, and scientific applications. The development of transparent ultrasound transducers enables successful integration by allowing precise align- ment between optical and acoustic paths. However, acoustic characterization of transparent ultrasound transducers has mainly focused on basic imaging parameters, while comprehensive evaluation of acoustic output and safety validation remains limited. This study aims to provide comprehensive acoustic characterization and safety validation of transparent ultrasound transducer (TT) through systematic comparison with opaque ultrasound transducer (OT). In this study, TT and OT were fab- ricated with the same structural design and systematically evaluated by measuring acoustic, electrical, and safety parameters. Both exhibited similar performance with center frequencies (18-19 MHz), bandwidths (44-54%), elec- trical impedances (59 Ω and 30 Ω), and similar beam diameter (0.75-0.83 mm). The acoustic output parameters of TT (1.14 MPa, 4.29 mW/cm ) were comparable to OT (1.12 MPa, 4.42 mW/cm ), with mechanical (0.26) and thermal 399 2 2 indices (<0.01) within safety guidelines. A systematic comparative analysis between TT and OT, focusing on acoustic characteristics and safety parameters, provides essential reference data. This comprehensive evaluation enables more informed decisions in selecting and implementing TTs in optical-ultrasound integrated systems.

Abstract

Ultrasound technology is being integrated with optical systems in biomedical, industrial, and scientific applications. The development of transparent ultrasound transducers enables successful integration by allowing precise align- ment between optical and acoustic paths. However, acoustic characterization of transparent ultrasound transducers has mainly focused on basic imaging parameters, while comprehensive evaluation of acoustic output and safety validation remains limited. This study aims to provide comprehensive acoustic characterization and safety validation of transparent ultrasound transducer (TT) through systematic comparison with opaque ultrasound transducer (OT). In this study, TT and OT were fab- ricated with the same structural design and systematically evaluated by measuring acoustic, electrical, and safety parameters. Both exhibited similar performance with center frequencies (18-19 MHz), bandwidths (44-54%), elec- trical impedances (59 Ω and 30 Ω), and similar beam diameter (0.75-0.83 mm). The acoustic output parameters of TT (1.14 MPa, 4.29 mW/cm ) were comparable to OT (1.12 MPa, 4.42 mW/cm ), with mechanical (0.26) and thermal39922 indices (<0.01) within safety guidelines. A systematic comparative analysis between TT and OT, focusing on acoustic characteristics and safety parameters, provides essential reference data. This comprehensive evaluation enables more informed decisions in selecting and implementing TTs in optical-ultrasound integrated systems.

참고문헌 (57)

  1. Yang Y, "Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization", Biomedical optics express, 2(9), pp.2551~2561 (2011)
  2. Chaki S, "Multi-technique approach for non-destructive diagnostic of structural composite materials using bulk ultrasonic waves, guided waves, acoustic emission and infrared thermography", Composites Part A : Applied Science and Manufacturing, 78, pp.358~361 (2015)
  3. Xie L, "Optical methods of laser ultrasonic testing technology in the industrial and engineering applications : A review", Optics & Laser Technology, 176, pp.110876~ (2024)
  4. Kim J, "Review on Photoacoustic Monitoring after Drug Delivery : From Label-Free Biomarkers to Pharmacokinetics Agents", Pharmaceutics, 16(10), pp.1240~ (2024)
  5. Park J, "Clinical Translation of Photoacoustic Imaging", Nature Reviews Bioengineering, pp.1~20 (2024)
  6. Yoon C, "Deep learning-based virtual staining, segmentation, and classification in label-free photoacoustic histology of human specimens", Light : Science & Applications, 13(1), pp.226~ (2024)
  7. Choi S, "X-ray free-electron laser induced acoustic microscopy(XFELAM)", Photoacoustics, 35, pp.100587~ (2024)
  8. Lee C, "Panoramic volumetric clinical handheld photoacoustic and ultrasound imaging", Photoacoustics, 31, pp.100512~ (2023)
  9. Choi S, "Deep learning enhances multiparametric dynamic volumetric photoacoustic computed tomography in vivo(DLPACT)", Advanced Science, 10(1), pp.2202089~ (2023)
  10. Kim J, "Deep learning acceleration of multiscale super resolution localization photoacoustic imaging", Light : science & applications, 11(1), pp.131~ (2022)
  11. Cheng Z, "High resolution ultrasonic neural modulation observed via in vivo twophoton calcium imaging", Brain Stimulation, 15(1), pp.190~196 (2022)
  12. Choi JR, "Investigation of an optical imaging platform integrated with an ultrasound application system for in vitro verification of ultrasound-mediated drug delivery", Applied Sciences, 11(6), pp.2846~ (2021)
  13. Kim D, "Quantitative volumetric photoacoustic assessment of vasoconstriction by topical corticosteroid application in mice skin", Photoacoustics, pp.100658~ (2024)
  14. Ibsen S, "Fluorescent microscope system to monitor real-time interactions between focused ultrasound, echogenic drug delivery vehicles, and live cell membranes", Ultrasonics, 53(1), pp.178~184 (2013)
  15. Kim H, "Nonlinear beamforming for intracardiac echocardiography: a comparative study", Biomedical Engineering Letters, pp.1~12 (2024)
  16. Oh D, "Contrast agent-free 3D renal ultrafast doppler imaging reveals vascular dysfunction in acute and diabetic kidney diseases", Advanced Science, 10(36), pp.2303966~ (2023)
  17. Kim J, "3d multiparametric photoacoustic computed tomography of primary and metastatic tumors in living mice", ACS nano, 18(28), pp.18176~18190 (2024)
  18. Ahn J, "In vivo photoacoustic monitoring of vasoconstriction induced by acute hyperglycemia", Photoacoustics, 30, pp.100485~ (2023)
  19. Ahn J, "Fully integrated photoacoustic microscopy and photoplethysmography of human in vivo", Photoacoustics, 27, pp.100374~ (2022)
  20. Choi W, "Three-dimensional multistructural quantitative photoacoustic and US imaging of human feet in vivo", Radiology, 303(2), pp.467~473 (2022)
  21. Baik JW, "Intraoperative label-free photoacoustic histopathology of clinical specimens", Laser & Photonics Reviews, 15(10), pp.2100124~ (2021)
  22. Kim J, "Multiparametric photoacoustic analysis of human thyroid cancers in vivo", Cancer Research, 81(18), pp.4849~4860 (2021)
  23. Ahn J, "High-resolution functional photoacoustic monitoring of vascular dynamics in human fingers", Photoacoustics, 23, pp.100282~ (2021)
  24. Cheng Z, "High resolution ultrasonic neural modulation observed via in vivo twophoton calcium imaging", Brain Stimulation, 15(1), pp.190~196 (2022)
  25. Liu RL, "Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging", Journal of Pharmaceutical Analysis, 12(4), pp.530~540 (2022)
  26. Li X, "Integrated IVUS-OCT imaging for atherosclerotic plaque characterization", IEEE Journal of Selected Topics in Quantum Electronics, 20(2), pp.196~203 (2013)
  27. Molony DS, "Evaluation of a framework for the co-registration of intravascular ultrasound and optical coherence tomography coronary artery pullbacks", Journal of biomechanics, 49(16), pp.4048~4056 (2016)
  28. Qi W, "Confocal acoustic radiation force optical coherence elastography using a ring ultrasonic transducer", Applied physics letters, 104(12) (2014)
  29. Wang M, "Realtime cavitation monitoring during optical coherence tomography guided photo-mediated ultrasound therapy of the retina", IEEE Transactions on Biomedical Engineering (2024)
  30. Yoo J, "Collapse pressure measurement of single hollow glass microsphere using single-beam acoustic tweezer", Ultrasonics Sonochemistry, 82, pp.105844~ (2022)
  31. Chamanzar M, "Ultrasonic sculpting of virtual optical waveguides in tissue", Nature communications, 10(1), pp.92~ (2019)
  32. Park B, "Shear-force photoacoustic microscopy : toward super-resolution near-field imaging", Laser & Photonics Reviews, 16(12), pp.2200296~ (2022)
  33. Maslov K, "Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries", Optics letters, 33(9), pp.929~931 (2008)
  34. Hu S, "Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed", Optics letters, 36(7), pp.1134~1136 (2011)
  35. Kim JY, "Fast optical-resolution photoacoustic microscopy using a 2-axis water-proofing MEMS scanner", Scientific reports, 5(1), pp.7932~ (2015)
  36. Maslov K, "In vivo dark-field reflectionmode photoacoustic microscopy", Optics letters, 30(6), pp.625~627 (2005)
  37. Song W, "Reflection-mode in vivo photoacoustic microscopy with subwavelength lateral resolution", Biomedical optics express, 5(12), pp.4235~4241 (2014)
  38. Dangi A, "Lithium niobate-based transparent ultrasound transducers for photoacoustic imaging", Optics letters, 44(21), pp.5326~5329 (2019)
  39. Chen H, "Optical-resolution photoacoustic microscopy using transparent ultrasound transducer", Sensors, 9(24), pp.5470~ (2019)
  40. Zhang J, "Broadband transparent ultrasound transducer with polymethyl methacrylate as matching layer for in vivo photoacoustic microscopy", Photoacoustics, 33, pp.100548~ (2023)
  41. Park J, "Quadruple ultrasound, photoacoustic, optical coherence, and fluorescence fusion imaging with a transparent ultrasound transducer", Proceedings of the National Academy of Sciences, 118(11), pp.e1920879118~ (2021)
  42. Cho S, "An ultrasensitive and broadband transparent ultrasound transducer for ultrasound and photoacoustic imaging in-vivo", Nature Communications, 15(1), pp.1444~ (2024)
  43. Kim J, "Enhanced Dual-Mode Imaging: Superior Photoacoustic and Ultrasound Microendoscopy in Live Pigs Using a Transparent Ultrasound Transducer", Science Advances, 10(47), pp.eadq9960~ (2024)
  44. Kim D, "An ultraviolet-transparent ultrasound transducer enables high-resolution label-free photoacoustic histopathology", Laser & Photonics Reviews, 18(2), pp.2300652~ (2023)
  45. Castillo M, "KLM model for lossy piezoelectric transducers", Ultrasonics, 41(8), pp.671~679 (2003)
  46. Sun P, "Design and fabrication of PINPMN-PT single-crystal high-frequency ultrasound transducers", IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 56(12), pp.2760~2763 (2009)
  47. Hedrick WR, "An overview of thermal and mechanical acoustic output indices", Journal of Diagnostic Medical Sonography, 9(5), pp.228~235 (1993)
  48. Zeng Y, "Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis : "Always-On"and"Turn-On"Probes", Advanced Science, 9(25), pp.2202384~ (2022)
  49. Jeon S, "Non-destructive photoacoustic imaging of metal surface defects", Journal of Optics, 18(11), pp.114001~ (2016)
  50. Kim Y, "Detection of micro inclusions in steel sheets using high-frequency ultrasound speckle analysis", Scientific reports, 11(1), pp.20416~ (2021)
  51. Kim H, "Deep laser microscopy using optical clearing by ultrasoundinduced gas bubbles", Nature Photonics, 16(11), pp.762~768 (2022)
  52. Kim C, "In vivo photoacoustic tomography of chemicals : high-resolution functional and molecular optical imaging at new depths", Chemical reviews, 110(5), pp.2756~2782 (2010)
  53. Cai X, "In vivo quantitative evaluation of the transport kinetics of gold nanocages in a lymphatic system by noninvasive photoacoustic tomography", Acs Nano, 5(12), pp.9658~9667 (2011)
  54. Zhang Y, "Non-invasive multimodal functional imaging of the intestine with frozen micellar naphthalocyanines", Nature nanotechnology, 9(8), pp.631~638 (2014)
  55. Cui H, "In vivo imaging and treatment of solid tumor using integrated photoacoustic imaging and high intensity focused ultrasound system", Medical physics, 37(9), pp.4777~4781 (2010)
  56. Yang J, "Multiplane Spectroscopic Whole-Body Photoacoustic Computed Tomography of Small Animals", Vivo. Laser & Photonics Reviews, pp.2400672~ (2024)
  57. Choi W, "Recent advances in contrast-enhanced photoacoustic imaging : overcoming the physical and practical challenges", Chemical Reviews, 123(11), pp.7379~7419 (2023)

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