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경피적 귀 미주신경 자극이 자율신경계의 활동 및 식후 혈당 변화에 미치는 영향

Effects of Transcutaneous Auricular Vagus Nerve Stimulation on the Activity of Autonomic Nervous System and Postprandial Blood Glucose Levels

조승관|김현|김도용|김한성|이민주|이한아
대한의용생체공학회 (The Korea Society Of Medical & Biological Engineering)|2023.02|의공학회지 (Journal of biomedical Engineering Research)|제44권 제1호|pp. 33-40

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참고문헌

키워드

Heart rateautonomic nervous systemTranscutaneous auricular vagus nerve stimulationPostprandial blood glu- cose levelsSkin conductance level

초록

Transcutaneous auricular vagus nerve stimulation (taVNS) is known to be effective in improving symp- toms of numerous diseases such as depression and epilepsy by increasing vagus nerve activity through electrical stimulation. The purpose of this study is to investigate the effect of vagus nerve stimulation on the activity of auto- nomic nervous system and the changes in postprandial blood glucose levels. Seven healthy adults participated in a non-invasive transcutaneous auricular vagus nerve stimulation experiment. taVNS (25 Hz, 200 µs, biphasic pulse) was applied to the cymba concha (taVNS group) or the earlobe (Sham-taVNS group) of the left ear. As autonomic nervous system signals, skin conductance level, skin temperature, and heart rate were recorded during the appli- cation of taVNS. Postprandial blood glucose changes due to food intake were recorded at 5 min intervals for 25 min- utes after taVNS or sham-taVNS. The taVNS showed a significantly lower skin conductance level than the sham- taVNS (p < 0.05). The increase rate of postprandial blood glucose was significantly lower in the taVNS than in the sham-taVNS (p < 0.05). These results showed that taVNS reduced the activity of the sympathetic nerve system and alleviated early rise in postprandial blood glucose. Although further studies in diabetic patients are needed, this study suggest that taVNS has a potential for clinical use to improve postprandial blood glucose.

Abstract

Transcutaneous auricular vagus nerve stimulation (taVNS) is known to be effective in improving symp- toms of numerous diseases such as depression and epilepsy by increasing vagus nerve activity through electrical stimulation. The purpose of this study is to investigate the effect of vagus nerve stimulation on the activity of auto- nomic nervous system and the changes in postprandial blood glucose levels. Seven healthy adults participated in a non-invasive transcutaneous auricular vagus nerve stimulation experiment. taVNS (25 Hz, 200 µs, biphasic pulse) was applied to the cymba concha (taVNS group) or the earlobe (Sham-taVNS group) of the left ear. As autonomic nervous system signals, skin conductance level, skin temperature, and heart rate were recorded during the appli- cation of taVNS. Postprandial blood glucose changes due to food intake were recorded at 5 min intervals for 25 min- utes after taVNS or sham-taVNS. The taVNS showed a significantly lower skin conductance level than the sham- taVNS (p < 0.05). The increase rate of postprandial blood glucose was significantly lower in the taVNS than in the sham-taVNS (p < 0.05). These results showed that taVNS reduced the activity of the sympathetic nerve system and alleviated early rise in postprandial blood glucose. Although further studies in diabetic patients are needed, this study suggest that taVNS has a potential for clinical use to improve postprandial blood glucose.

참고문헌 (40)

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