Vagus Nerves Stimulation: Clinical Implication and Practical Issue as a Neuropsychiatric Treatment
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Vagus nerve stimulation (VNS) has been approved as an adjunctive treatment for epilepsy and depression. As the progress of VNS treatment for these neuropsychiatric disorders continues, its applications have expanded to a wide range of conditions, including inflammatory diseases to cognitive dysfunctions. The branches of the vagal nerves directly or indirectly innervate the anatomical structures implicated in these neuropsychiatric conditions, which has led to promising results regarding the effectiveness of VNS. Previous studies investigating the effectiveness of VNS have mostly utilized invasive forms of stimulation. However, current preclinical and clinical research indicates that non-invasive forms of VNS, such as transcutaneous vagus nerve stimulation, hold the promise for treating various neuropsychiatric conditions. This review aims to delve into relevant clinical studies of VNS in various illness states, different methods of VNS, and the potential mechanisms underlying the therapeutic effects in these neuropsychiatric conditions.
Abstract
Vagus nerve stimulation (VNS) has been approved as an adjunctive treatment for epilepsy and depression. As the progress of VNS treatment for these neuropsychiatric disorders continues, its applications have expanded to a wide range of conditions, including inflammatory diseases to cognitive dysfunctions. The branches of the vagal nerves directly or indirectly innervate the anatomical structures implicated in these neuropsychiatric conditions, which has led to promising results regarding the effectiveness of VNS. Previous studies investigating the effectiveness of VNS have mostly utilized invasive forms of stimulation. However, current preclinical and clinical research indicates that non-invasive forms of VNS, such as transcutaneous vagus nerve stimulation, hold the promise for treating various neuropsychiatric conditions. This review aims to delve into relevant clinical studies of VNS in various illness states, different methods of VNS, and the potential mechanisms underlying the therapeutic effects in these neuropsychiatric conditions.
참고문헌 (87)
- Browning KN, "Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions", Compr Physiol, 4, pp.1339~1368 (2014)
- Yu ZJ, "Vagus nerve stimulation : Can it be used in adolescents or children with treatment-resistant depression?", Curr Psychiatry Rep, 10, pp.116~122 (2008)
- Zhu S, "Therapeutic applications of transcutaneous auricular vagus nerve stimulation with potential for application in neurodevelopmental or other pediatric disorders", Front Endocrinol(Lausanne), 13, pp.1000758~ (2022)
- Foley JO, "Quantitative studies of the vagus nerve in the cat : I. The ratio of sensory to motor fibers", J Nerv Ment Dis, 86, pp.587~ (1937)
- Berthoud HR, "Functional and chemical anatomy of the afferent vagal system", Auton Neurosci, 85, pp.1~17 (2000)
- Bonaz B, "Vagus nerve stimulation : From epilepsy to the cholinergic anti-inflammatory pathway", Neurogastroenterol Motil, 25, pp.208~221 (2013)
- Zagon A, "Does the vagus nerve mediate the sixth sense?", Trends Neurosci, 24, pp.671~673 (2001)
- Henry TR, "Therapeutic mechanisms of vagus nerve stimulation", Neurology, 59(6 Suppl 4), pp.S3~S14 (2002)
- Terry RS, "The implantable neurocybernetic prosthesis system", Pacing Clin Electrophysiol, 14, pp.86~93 (1991)
- Schachter SC, "Vagus nerve stimulation", Epilepsia, 39, pp.677~686 (1998)
- Saper CB, "Brain natriuretic peptide-like immunoreactive innervation of the cardiovascular and cerebrovascular systems in the rat", Circ Res, 67, pp.1345~1354 (1990)
- De Ferrari GM, "Chronic vagus nerve stimulation : A new and promising therapeutic approach for chronic heart failure", Eur Heart J, 32, pp.847~855 (2011)
- Schwartz PJ, "Sympathetic-parasympathetic interaction in health and disease : Abnormalities and relevance in heart failure", Heart Fail Rev, 16, pp.101~107 (2011)
- Busch V, "The effect of transcutaneous vagus nerve stimulation on pain perception--an experimental study", Brain Stimul, 6, pp.202~209 (2013)
- Dietrich S, "A novel transcutaneous vagus nerve stimulation leads to brainstem and cerebral activations measured by functional MRI", BMT, 53, pp.104~111 (2008)
- Kraus T, "BOLD fMRI deactivation of limbic and temporal brain structures and mood enhancing effect by transcutaneous vagus nerve stimulation", J Neural Transm(Vienna), 114, pp.1485~1493 (2007)
- Howland RH, "Vagus nerve stimulation", Curr Behav Neurosci Rep, 1, pp.64~73 (2014)
- George MS, "Vagus nerve stimulation : A new tool for brain research and therapy", Biol Psychiatry, 47, pp.287~295 (2000)
- Dailey JW, "Neurochemical correlates of antiepileptic drugs in the genetically epilepsy-prone rat(GEPR)", Life Sci, 58, pp.259~266 (1996)
- Krahl SE, "Seizure suppression by systemic epinephrine is mediated by the vagus nerve", Epilepsy Res, 38, pp.171~175 (2000)
- Walker BR, "Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius", Epilepsia, 40, pp.1051~1057 (1999)
- Browning RA, "Effect of norepinephrine depletion on audiogenic-like seizures elicited by microinfusion of an excitant amino acid into the inferior colliculus of normal rats", Exp Neurol, 112, pp.200~205 (1991)
- Krahl SE, "Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation", Epilepsia, 39, pp.709~714 (1998)
- Ben-Menachem E, "Vagus nerve stimulation for treatment of partial seizures : 1. A controlled study of effect on seizures", Epilepsia, 35, pp.616~626 (1994)
- Labar D, "Vagus nerve stimulation for 1 year in 269 patients on unchanged antiepileptic drugs", Seizure, 13, pp.392~398 (2004)
- Morris GL 3rd, "Long-term treatment with vagus nerve stimulation in patients with refractory epilepsy", Neurology, 53, pp.1731~1735 (1999)
- Amar AP, "Vagus nerve stimulation therapy after failed cranial surgery for intractable epilepsy : Results from the vagus nerve stimulation therapy patient outcome registry", Neurosurgery, 55, pp.1086~1093 (2004)
- DeGiorgio CM, "Prospective long-term study of vagus nerve stimulation for the treatment of refractory seizures", Epilepsia, 41, pp.1195~1200 (2000)
- Kawai K, "Outcome of vagus nerve stimulation for drug-resistant epilepsy : The first three years of a prospective Japanese registry", Epileptic Disord, 19, pp.327~338 (2017)
- Orosz I, "Vagus nerve stimulation for drug-resistant epilepsy : A European long-term study up to 24 months in 347children", Epilepsia, 55, pp.1576~1584 (2014)
- Patwardhan RV, "Efficacy of vagal nerve stimulation in children with medically refractory epilepsy", Neurosurgery, 47, pp.1353~1357 (2000)
- Elliott RE, "Efficacy of vagus nerve stimulation over time : Review of 65 consecutive patients with treatment-resistant epilepsy treated with VNS > 10 years", Epilepsy Behav, 20, pp.478~483 (2011)
- Eriksson KJ, "Prevalence, classification, and severity of epilepsy and epileptic syndromes in children", Epilepsia, 38, pp.1275~1282 (1997)
- Berg AT, "Early development of intractable epilepsy in children : A prospective study", Neurology, 56, pp.1445~1452 (2001)
- Helmers SL, "Vagus nerve stimulation therapy in pediatric patients with refractory epilepsy : Retrospective study", J Child Neurol, 16, pp.843~848 (2001)
- Levy ML, "Vagus nerve stimulation therapy in patients with autism spectrum disorder and intractable epilepsy : Results from the vagus nerve stimulation therapy patient outcome registry", J Neurosurg Pediatr, 5, pp.595~602 (2010)
- Barbella G, "Transcutaneous vagal nerve stimulatio(t-VNS) : An adjunctive treatment option for refractory epilepsy", Seizure, 60, pp.115~119 (2018)
- Bauer S, "Transcutaneous vagus nerve stimulation(tVNS)for treatment of drug-resistant epilepsy : A randomized, doubleblind clinical trial(cMPsE02)", Brain Stimul, 9, pp.356~363 (2016)
- Rong P, "An alternative therapy for drug-resistant epilepsy : Transcutaneous auricular vagus nerve stimulation", Chin Med J(Engl), 127, pp.300~304 (2014)
- Rong P, "Transcutaneous vagus nerve stimulation for refractory epilepsy:A randomized controlled trial", Clin Sci (Lond) (2014)[DOI]
- He W, "Transcutaneous auricular vagus nerve stimulation as a complementary therapy for pediatric epilepsy : A pilot trial", Epilepsy Behav, 28, pp.343~346 (2013)
- Lampros M, "Transcutaneous vagus nerve stimulation(t-VNS)and epilepsy : A systematic review of the literature", Seizure, 91, pp.40~48 (2021)
- He W, "Transcutaneous auricular vagus nerve stimulation for pediatric epilepsy : Study protocol for a randomized controlled trial", Trials, 16, pp.371~ (2015)
- Nemeroff CB, "VNS therapy in treatment-resistant depression : Clinical evidence and putative neurobiological mechanisms", Neuropsychopharmacology, 31, pp.1345~1355 (2006)
- Ben-Menachem E, "Effects of vagus nerve stimulation on amino acids and other metabolites in the CSF of patients with partial seizures", Epilepsy Res, 20, pp.221~227 (1995)
- Henry TR, "Brain blood flow alterations induced by therapeutic vagus nerve stimulation in partial epilepsy : I. Acute effects at high and low levels of stimulation", Epilepsia, 39, pp.983~990 (1998)
- Bohning DE, "Feasibility of vagus nerve stimulation-synchronized blood oxygenation level-dependent functional MRI", Invest Radiol, 36, pp.470~479 (2001)
- Handforth A, "Vagus nerve stimulation therapy for partial-onset seizures : A randomized active-control trial", Neurology, 51, pp.48~55 (1998)
- Harden CL, "Effect of vagus nerve stimulation on mood in adult epilepsy patients", Neurology, 52, pp.A238~ (1999)
- Goodwin FK, "Manic-depressive illness:Bipolar disorders and recurrent depression" (2007), Oxford University Press
- Post RM, "Mechanisms of action of anticonvulsants in affective disorders : Comparisons with lithium", J Clin Psychopharmacol, 12(1 Suppl), pp.23~ (1992)
- Rush AJ, "Vagus nerve stimulation(VNS)for treatmentresistant depressions : A multicenter study", Biol Psychiatry, 47, pp.276~286 (2000)
- Rush AJ, "Vagus nerve stimulation for treatment-resistant depression : A randomized, controlled acute phase trial", Biol Psychiatry, 58, pp.347~354 (2005)
- Rush AJ, "Effects of 12 months of vagus nerve stimulation in treatment-resistant depression : A naturalistic study", Biol Psychiatry, 58, pp.355~363 (2005)
- Aaronson ST, "A 5-year observational study of patients with treatment-resistant depression treated with vagus nerve stimulation or treatment as usual : Comparison of response, remission, and suicidality", Am J Psychiatry, 174, pp.640~648 (2017)
- Bottomley JM, "Vagus nerve stimulation(VNS)therapy in patients with treatment resistant depression : A systematic review and meta-analysis", Compr Psychiatry, 98, pp.152156~ (2019)
- Kong J, "Treating depression with transcutaneous auricular vagus nerve stimulation : State of the art and future perspectives", Front Psychiatry, 9, pp.20~ (2018)
- Rong P, "Effect of transcutaneous auricular vagus nerve stimulation on major depressive disorder : A nonrandomized controlled pilot study", J Affect Disord, 195, pp.172~179 (2016)
- Austelle CW, "A Comprehensive review of vagus nerve stimulation for depression", Neuromodulation, 25, pp.309~315 (2022)
- Oh J, "Effect of home-based self-administered transcranial direct stimulation in patients with mild to moderate major depressive disorder : A single-arm, multicentral trial", Clin Psychopharmacol Neurosci, 21, pp.271~278 (2023)
- Oh J, "Effect of self-administered transcranial direct stimulation in patients with major depressive disorder : A randomized, single-blinded clinical trial", Clin Psychopharmacol Neurosci, 20, pp.87~96 (2022)
- Meron D, "Transcranial direct current stimulation(tDCS)in the treatment of depression : Systematic review and meta-analysis of efficacy and tolerability", Neurosci Biobehav Rev, 57, pp.46~62 (2015)
- Razza LB, "A systematic review and meta-analysis on the effects of transcranial direct current stimulation in depressive episodes", Depress Anxiety, 37, pp.594~608 (2020)
- Palm U, "tDCS for the treatment of depression : A comprehensive review", Eur Arch Psychiatry Clin Neurosci, 266, pp.681~694 (2016)
- Kamel LY, "Vagus nerve stimulation : An update on a novel treatment for treatment-resistant depression", J Neurol Sci, 434, pp.120171~ (2022)
- Tracey KJ, "The inflammatory reflex", Nature, 420, pp.853~859 (2002)
- Pavlov VA, "The cholinergic anti-inflammatory pathway : A missing link in neuroimmunomodulation", Mol Med, 9, pp.125~134 (2003)
- Borovikova LV, "Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin", Nature, 405, pp.458~462 (2000)
- Chang EH, "Cholinergic control of inflammation, metabolic dysfunction, and cognitive impairment in obesity-associated disorders : Mechanisms and novel therapeutic opportunities", Front Neurosci, 13, pp.263~ (2019)
- Pavlov VA, "Neural circuitry and immunity", Immunol Res, 63, pp.38~57 (2015)
- Drewes AM, "Short-term transcutaneous non-invasive vagus nerve stimulation may reduce disease activity and pro-inflammatory cytokines in rheumatoid arthritis : Results of a pilot study", Scand J Rheumatol, 50, pp.20~27 (2021)
- Levine YA, "Neurostimulation of the cholinergic anti-inflammatory pathway ameliorates disease in rat collagen-induced arthritis", PLoS One, 9, pp.e104530~ (2014)
- Meregnani J, "Anti-inflammatory effect of vagus nerve stimulation in a rat model of inflammatory bowel disease", Auton Neurosci, 160, pp.82~89 (2011)
- Sinniger V, "A 12-month pilot study outcomes of vagus nerve stimulation in Crohn’s disease", Neurogastroenterol Motil, 32, pp.e13911~ (2020)
- Lange G, "Safety and efficacy of vagus nerve stimulation in fibromyalgia : A phase I", II proof of concept trial, 2011, pp.12, 1406~1413
- Clark KB, "Posttraining electrical stimulation of vagal afferents with concomitant vagal efferent inactivation enhances memory storage processes in the rat", Neurobiol Learn Mem, 70, pp.364~373 (1998)
- Clark KB, "Post-training unilateral vagal stimulation enhances retention performance in the rat", Neurobiol Learn Mem, 63, pp.213~216 (1995)
- Zuo Y, "Vagus nerve stimulation potentiates hippocampal LTP in freely-moving rats", Physiol Behav, 90, pp.583~589 (2007)
- Sucholeiki R, "fMRI in patients implanted with a vagal nerve stimulator", Seizure, 11, pp.157~162 (2002)
- Conway CR, "Cerebral blood flow changes during vagus nerve stimulation for depression", Psychiatry Res, 146, pp.179~184 (2006)
- Sjögren MJ, "Cognition-enhancing effect of vagus nerve stimulation in patients with Alzheimer’s disease : A pilot study", J Clin Psychiatry, 63, pp.972~980 (2002)
- Bondareff W, "Loss of neurons of origin of the adrenergic projection to cerebral cortex(nucleus locus ceruleus)in senile dementia", Neurology, 32, pp.164~168 (1982)
- Clark KB, "Enhanced recognition memory following vagus nerve stimulation in human subjects", Nat Neurosci, 2, pp.94~98 (1999)
- Martin CO, "The effects of vagus nerve stimulation on decision-making", Cortex, 40, pp.605~612 (2004)
- Helmstaedter C, "Memory alterations during acute high-intensity vagus nerve stimulation", Epilepsy Res, 47, pp.37~42 (2001)
- Jacobs HI, "Transcutaneous vagus nerve stimulation boosts associative memory in older individuals", Neurobiol Aging, 36, pp.1860~1867 (2015)
- Colzato LS, "Transcutaneous vagus nerve stimulation(tVNS)enhances divergent thinking", Neuropsychologia, 111, pp.72~76 (2018)
