중증 안구표면질환에서 경피 전기 자극 치료의 효과
Effect of Transcutaneous Electrical Stimulation Therapy in Severe Ocular Surface Disease
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초록
This study aimed to evaluate the clinical efficacy and safety of transcutaneous electrical stimulation (TES) in patients with severe ocular surface disease. TES has been recognized as a potential treatment for enhancing cor- neal epithelial healing and stabilizing the tear film, offering a solution to the limitations of conventional therapies that provide only temporary symptom relief. A single-blind, sham-controlled, prospective clinical trial was conducted with seven patients suffering from persistent corneal epithelial defects. The participants were divided into a TES group receiving TES therapy and a control group receiving sham stimulation. The primary outcome was the change in the corneal epithelial defect area, and the secondary outcomes included the change in the corneal sensitivity, tear secre- tion, and tear film breakup time (TBUT). Each patient used the device daily for 30 minutes over a 4-week period. After four weeks, the TES group showed a significant reduction in the corneal epithelial defect area, decreasing to 10% of the initial value, while the control group exhibited a 132% increase (p = 0.034). However, no statistically sig- nificant changes were observed in corneal sensitivity, tear secretion, and TBUT, suggesting limited effects on tear secretion and tear film stability in severe ocular surface disease. TES can effectively promote corneal epithelial heal- ing in patients with severe ocular surface disease.
Abstract
This study aimed to evaluate the clinical efficacy and safety of transcutaneous electrical stimulation (TES) in patients with severe ocular surface disease. TES has been recognized as a potential treatment for enhancing cor- neal epithelial healing and stabilizing the tear film, offering a solution to the limitations of conventional therapies that provide only temporary symptom relief. A single-blind, sham-controlled, prospective clinical trial was conducted with seven patients suffering from persistent corneal epithelial defects. The participants were divided into a TES group receiving TES therapy and a control group receiving sham stimulation. The primary outcome was the change in the corneal epithelial defect area, and the secondary outcomes included the change in the corneal sensitivity, tear secre- tion, and tear film breakup time (TBUT). Each patient used the device daily for 30 minutes over a 4-week period. After four weeks, the TES group showed a significant reduction in the corneal epithelial defect area, decreasing to 10% of the initial value, while the control group exhibited a 132% increase (p = 0.034). However, no statistically sig- nificant changes were observed in corneal sensitivity, tear secretion, and TBUT, suggesting limited effects on tear secretion and tear film stability in severe ocular surface disease. TES can effectively promote corneal epithelial heal- ing in patients with severe ocular surface disease.
참고문헌 (18)
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