건성안 증후군에 대한 전자뜸과 침의 효과 비교 임상연구
A Comparative Clinical Study on an Electronic Moxibustion with Acupuncture for Dry Eye Syndrome
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Objectives : Recently, the number of patients with dry eye syndrome has been steadily increasing. However, established treatment for it does not yet exist. This study compared electronic moxibustion with acupuncture for patients with dry eye in terms of efficacy and safety. Methods : This trial was designed as an investigator-initiated, single-blinded, comparative, randomized controlled trial. Thirty patients with dry eye were randomized to the electronic moxibustion treatment group(EMG) or the acupuncture treatment group(AG) in equal proportion. The participants who assigned to the EMG were treated with electronic moxibustion to ten acupoints including both sides of BL2, GB14, TE23, and LI4 for 12 minutes. The participants who were assigned to the AG were treated with acupuncture to the same acupoints for 15 minutes. Over 4 weeks, each intervention was carried out twelve times in total. The primary outcome was the ocular surface disease index(OSDI). The secondary outcomes were the subjective symptoms visual analog scale(VAS), quality of life(QoL), Schirmer Ⅰ test(SIT), and general assessment. Adverse events and vital signs were also investigated for safety assessment. Results : In intragroup comparisons, both the EMG and the AG significantly improved the OSDI scores, the subjective symptoms VAS scores, the QoL scores, and the SIT results after 4 weeks of the trial. However, there were no statistical differences in intergroup comparisons between the two groups after 4 weeks. The safety of electronic moxibustion and acupuncture was confirmed by no occurrence of serious adverse events. Conclusions : Both electronic moxibustion and acupuncture were effective for dry eye syndrome, and they were safe. Electronic moxibustion and acupuncture can be used for dry eye syndrome as equivalent treatments.
Abstract
Objectives : Recently, the number of patients with dry eye syndrome has been steadily increasing. However, established treatment for it does not yet exist. This study compared electronic moxibustion with acupuncture for patients with dry eye in terms of efficacy and safety. Methods : This trial was designed as an investigator-initiated, single-blinded, comparative, randomized controlled trial. Thirty patients with dry eye were randomized to the electronic moxibustion treatment group(EMG) or the acupuncture treatment group(AG) in equal proportion. The participants who assigned to the EMG were treated with electronic moxibustion to ten acupoints including both sides of BL2, GB14, TE23, and LI4 for 12 minutes. The participants who were assigned to the AG were treated with acupuncture to the same acupoints for 15 minutes. Over 4 weeks, each intervention was carried out twelve times in total. The primary outcome was the ocular surface disease index(OSDI). The secondary outcomes were the subjective symptoms visual analog scale(VAS), quality of life(QoL), Schirmer Ⅰ test(SIT), and general assessment. Adverse events and vital signs were also investigated for safety assessment. Results : In intragroup comparisons, both the EMG and the AG significantly improved the OSDI scores, the subjective symptoms VAS scores, the QoL scores, and the SIT results after 4 weeks of the trial. However, there were no statistical differences in intergroup comparisons between the two groups after 4 weeks. The safety of electronic moxibustion and acupuncture was confirmed by no occurrence of serious adverse events. Conclusions : Both electronic moxibustion and acupuncture were effective for dry eye syndrome, and they were safe. Electronic moxibustion and acupuncture can be used for dry eye syndrome as equivalent treatments.
참고문헌 (32)
- Kim HS, "Ophthalmology", pp.115~118 (2020), Ilchokak
- Uchino M, "Prevalence of dry eye disease among Japanese visual display terminal users", Ophthalmology, 115(11), pp.1982~1988 (2008)
- Guo B, "Prevalence of dry eye disease in Mongolians at high altitude in China : the Henan eye study", Ophthalmic Epidemiol, 17(4), pp.234~241 (2010)
- Han SB, "Prevalence of dry eye disease in an elderly Korean population", Arch Ophthalmol, 129(5), pp.633~638 (2011)
- Yamada M, "Impact of dry eye on work productivity", Clinicoecon Outcomes Res, 4, pp.307~312 (2012)
- 박정숙, "스마트폰의 동영상과 게임 사용이 대학생의 안구건조에 미치는 영향", 지역사회간호학회지, 25(1), pp.12~23 (2014), 한국지역사회간호학회[DOI]
- 김효진, "신축건물에서 안구건조증이 작업생산성과 일상활동에 미치는 영향", 한국안광학회지, 19(3), pp.389~396 (2014), 한국안광학회
- 김대종, "사무실 실내공기질과 콘택트렌즈 착용여부가 안구 건조증에 미치는 영향", 한국안광학회지, 17(2), pp.215~222 (2012), 한국안광학회[DOI]
- "National Health Insurance Service" (2018)[URL]
- Perry HD, "Dry eye diagnosis and management in 2004", Curr Opin Ophthalmol, 15(4), pp.299~304 (2004)
- Smith RE, "The tear film complex : pathogenesis and emerging therapies for dry eyes", Cornea, 24(1), pp.1~7 (2005)
- Behrens A, "Dysfunctional tear syndrome : a Delphi approach to treatment recommendations", Cornea, 25(8), pp.900~907 (2006)
- Jeong DH, "A literature of study on Xerophthalmia", J Korean Med Ophthalmol Otolaryngol Dermatol, 15(1), pp.177~197 (2002)
- The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology, "Korean Medicine Ophthalmology", pp.108~ (2019), Globooks
- Kwon DH, "Book Research into Acupuncture Treatment for Dry Eye", J Acupunct Res, 17(3), pp.10~24 (2000)
- 최은희, "안구 건조증 환자의 치험 3례", Journal of Acupuncture Research, 24(4), pp.237~245 (2007), 대한침구의학회
- 이창우, "안구건조증 환자 43례의 침치료 효과에 대한 임상적 연구", Journal of Acupuncture Research, 27(6), pp.85~94 (2010), 대한침구의학회
- 이승민, "자침 횟수의 차이에 따른 안구건조증 치료 효과 비교", Journal of Acupuncture Research, 29(4), pp.55~69 (2012), 대한침구의학회[DOI]
- Kim BH, "Optimizing acupuncture treatment for dry eye syndrome : a systematic review", BMC Complement Altern Med, 18(1), pp.145~ (2018)
- Kim TH, "Acupuncture for the treatment of dry eye : a multicenter randomised controlled trial with active comparison intervention(artificial teardrops)", PLoS One, 7(5), pp.e36638~ (2012)
- 임경민, "한의학 학술지에 게재된 안구건조증에 대한 논문 고찰", 동의생리병리학회지, 31(2), pp.94~104 (2017), 한의병리학회[DOI]
- 이호찬, "안구건조증의 뜸 치료에 대한 체계적 문헌 고찰", 한방안이비인후피부과학회지, 32(1), pp.42~58 (2019), 대한한방안이비인후피부과학회[DOI]
- 송지훈, "건성안 증후군의 피내침 치료에 대한 임상연구 동향", 한방안이비인후피부과학회지, 33(2), pp.12~22 (2020), 대한한방안이비인후피부과학회[DOI]
- Julious SA, "Sample size of 12 per group rule of thumb for a pilot study", Pharm Stat, 4(4), pp.287~291 (2005)
- Miller KL, "Minimal clinically important difference for the ocular surface disease index", Arch Ophthalmol, 128(1), pp.94~101 (2010)
- Wei QB, "Acupoint selection for the treatment of dry eye : A systematic review and meta-analysis of randomized controlled trials", Exp Ther Med, 19(4), pp.2851~2860 (2020)
- 문인희, "건성안 환자들의 주관적인 안구 불편감과 안검염 중증도의 관계", 대한안과학회지, 57(10), pp.1507~1513 (2016), 대한안과학회
- Nichols KK, "The lack of association between signs and symptoms in patients with dry eye disease", Cornea, 23(8), pp.762~770 (2004)
- 현준영, "Korean Guidelines for the Diagnosis and Management of Dry Eye: Development and Validation of Clinical Efficacy", Korean Journal of Ophthalmology, 28(3), pp.197~206 (2014), 대한안과학회
- 이동진, "안구건조증환자 11례의 한 ․양방 병용치료에 대한 임상보고", 한방안이비인후피부과학회지, 25(2), pp.61~67 (2012), 대한한방안이비인후피부과학회[DOI]
- Dhaliwal DK, "Acupuncture and dry eye : current perspectives. A double-blinded randomized controlled trial and review of the literature", Clin Ophthalmol, 13, pp.731~740 (2019)
- Korean Acupuncture and Moxibustion Medicine Society Textbook Compilation Committee, "Acupuncture Medicine", pp.653~ (2020), Hanmi Medical Publishing Co