Clustering and Switching Patterns in Semantic Fluency and Their Relationship to Working Memory in Mild Cognitive Impairment
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초록
Background and Purpose: Semantic verbal fluency test is a neuropsychological assessment that can sensitively detect neuropathological changes. Considering its multifactorial features tapping various cognitive domains such as semantic memory, executive function, and working memory, it is necessary to examine verbal fluency performance in association with underlying cognitive functions. The objective of the current study was to investigate semantic fluency patterns of people with mild cognitive impairment (MCI) based on clustering and switching and their relationship with working memory. Methods: Twenty-six individuals with MCI and 23 normal elderly adults participated in this study. A semantic verbal fluency test (animal version) was administered and the performance was analyzed using the following measures: number of correct words, cluster size, and number of switches. Scores of digit forward (DF) and backward span tasks were employed as working memory measures. Results: Analyses of variance revealed significant group differences in the numbers of correct words and switches. Multivariate logistic regression and receiver-operating characteristic analyses showed that the number of switches more sensitively distinguished MCI existence than the number of correct words. Stepwise linear regression analysis showed that DF task and age significantly predicted the number of correct words while only the DF task significantly predicted the number of switches. Conclusions: Decrement in semantic verbal fluency in MCI seems to be associated with impaired switching abilities. Working memory capacity might serve as the underlying cognitive factor related to decreased verbal fluency in MCI.
Abstract
Background and Purpose: Semantic verbal fluency test is a neuropsychological assessment that can sensitively detect neuropathological changes. Considering its multifactorial features tapping various cognitive domains such as semantic memory, executive function, and working memory, it is necessary to examine verbal fluency performance in association with underlying cognitive functions. The objective of the current study was to investigate semantic fluency patterns of people with mild cognitive impairment (MCI) based on clustering and switching and their relationship with working memory. Methods: Twenty-six individuals with MCI and 23 normal elderly adults participated in this study. A semantic verbal fluency test (animal version) was administered and the performance was analyzed using the following measures: number of correct words, cluster size, and number of switches. Scores of digit forward (DF) and backward span tasks were employed as working memory measures. Results: Analyses of variance revealed significant group differences in the numbers of correct words and switches. Multivariate logistic regression and receiver-operating characteristic analyses showed that the number of switches more sensitively distinguished MCI existence than the number of correct words. Stepwise linear regression analysis showed that DF task and age significantly predicted the number of correct words while only the DF task significantly predicted the number of switches. Conclusions: Decrement in semantic verbal fluency in MCI seems to be associated with impaired switching abilities. Working memory capacity might serve as the underlying cognitive factor related to decreased verbal fluency in MCI.
참고문헌 (79)
- Morris JC, "Mild cognitive impairment is early-stage Alzheimer disease: time to revise diagnostic criteria", Arch Neurol, 63, pp.15~16 (2006)
- Petersen RC, "Mild cognitive impairment as a diagnostic entity", J Intern Med, 256, pp.183~194 (2004)
- Chertkow H, "Mild cognitive impairment", Curr Opin Neurol, 15, pp.401~407 (2002)
- Flicker C, "Mild cognitive impairment in the elderly: predictors of dementia", Neurology, 41, pp.1006~1009 (1991)
- Petersen RC, "Current concepts in mild cognitive impairment", Arch Neurol, 58, pp.1985~1992 (2001)
- Petersen RC, "Mild cognitive impairment: clinical characterization and outcome", Arch Neurol, 56, pp.303~308 (1999)
- Aguirre-Acevedo DC, "Cognitive decline in a Colombian kindred with autosomal dominant Alzheimer disease: a retrospective cohort study", JAMA Neurol, 73, pp.431~438 (2016)
- Rajan KB, "Cognitive impairment 18 years before clinical diagnosis of Alzheimer disease dementia", Neurology, 85, pp.898~904 (2015)
- De Jager CA, "Stability and predictability of the classification of mild cognitive impairment as assessed by episodic memory test performance over time", Neurocase, 11, pp.72~79 (2005)
- Ganguli M, "Mild cognitive impairment, amnestic type: an epidemiologic study", Neurology, 63, pp.115~121 (2004)
- Bäckman L, "Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis", Neuropsychology, 19, pp.520~531 (2005)
- 한노을, "조기발현과 지연발현 경도인지장애의 신경심리학적 특징과 치매로의 진행률 비교", Korean Journal of Clinical Psychology, 31(1), pp.373~390 (2012), 한국임상심리학회[DOI]
- Pérès K, "Restriction in complex activities of daily living in MCI: impact on outcome", Neurology, 67, pp.461~466 (2006)
- Yoon JH, "Neuropsychological evaluation of mild cognitive impairment: comparison of no cognitive impairment and early Alzheimer's disease", Korean J Clin Psychol Annu Conf, 6, pp.408~409 (2005)
- Belleville S, "Working memory and control of attention in persons with Alzheimer's disease and mild cognitive impairment", Neuropsychology, 21, pp.458~469 (2007)
- Taler V, "Knowledge of semantic features in mild cognitive impairment", J Neurolinguist, 38, pp.56~70 (2016)
- Bennett DA, "Natural history of mild cognitive impairment in older persons", Neurology, 59, pp.198~205 (2002)
- Cunje A, "Alternate forms of logical memory and verbal fluency tasks for repeated testing in early cognitive changes", Int Psychogeriatr, 19, pp.65~75 (2007)
- Ribeiro F, "Mild cognitive impairment: deficits in cognitive domains other than memory", Dement Geriatr Cogn Disord, 21, pp.284~290 (2006)
- Adlam AL, "Semantic knowledge in mild cognitive impairment and mild Alzheimer's disease", Cortex, 42, pp.675~684 (2006)
- Choi H, "A comparison of the performances of confrontation naming test and verbal fluency task in patients with prodromal Alzheimer's disease and mild Alzheimer's disease", Speech Sci, 15, pp.111~118 (2008)
- Murphy KJ, "Verbal fluency patterns in amnestic mild cognitive impairment are characteristic of Alzheimer's type dementia", J Int Neuropsychol Soc, 12, pp.570~574 (2006)
- Artero S, "Prediction of transition from cognitive impairment to senile dementia: a prospective, longitudinal study", Acta Psychiatr Scand, 107, pp.390~393 (2003)
- Fuld PA, "Object-memory evaluation for prospective detection of dementia in normal functioning elderly: predictive and normative data", J Clin Exp Neuropsychol, 12, pp.520~528 (1990)
- Saxton J, "Preclinical Alzheimer disease: neuropsychological test performance 1.5 to 8 years prior to onset", Neurology, 63, pp.2341~2347 (2004)
- Tabert MH, "Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment.", Arch Gen Psychiatry, 63, pp.916~924 (2006)
- Nebes RD, "Semantic memory in Alzheimer's disease", Psychol Bull, 106, pp.377~394 (1989)
- Troyer AK, "Clustering and switching as two components of verbal fluency: evidence from younger and older healthy adults", Neuropsychology, 11, pp.138~146 (1997)
- Henry JD, "Verbal fluency performance in dementia of the Alzheimer's type: a meta-analysis", Neuropsychologia, 42, pp.1212~1222 (2004)
- Kessler J, "Strategies and structures in verbal fluency tasks in patients with Alzheimer's disease", Behav Neurol, 10, pp.133~135 (1997)
- Shiffrin RM, "Controlled and automatic human information processing: II. Perceptual learning, automatic attending and a general theory", Psychol Rev, 84, pp.127~190 (1977)
- Azuma T, "Working memory and perseveration in verbal fluency", Neuropsychology, 18, pp.69~77 (2004)
- Fischer-Baum S, "Perseveration during verbal fluency in traumatic brain injury reflects impairments in working memory", Neuropsychology, 30, pp.791~799 (2016)
- Kraan C, "The abilities associated with verbal fluency performance in a young, healthy population are multifactorial and differ across fluency variants", Appl Neuropsychol Adult, 20, pp.159~168 (2013)
- Pakhomov SV, "Recurrent perseverations on semantic verbal fluency tasks as an early marker of cognitive impairment", J Clin Exp Neuropsychol, 40, pp.832~840 (2018)
- Rosen VM, "Forward and backward serial recall", Intelligence, 25, pp.37~47 (1997)
- Unsworth N, "Working memory capacity and retrieval limitations from long-term memory: an examination of differences in accessibility", Q J Exp Psychol (Hove), 65, pp.2397~2410 (2012)
- Baddeley AD, "Recent Advances in Learning and Motivation. Vol 8", pp.47~89 (1974), Academic Press
- Baddeley A, "Dementia and working memory", Q J Exp Psychol A, 38, pp.603~618 (1986)
- Cowan N, "Children's working-memory processes: a response-timing analysis", J Exp Psychol Gen, 132, pp.113~132 (2003)
- Healey MK, "The role of attention during retrieval in working-memory span: a dual-task study", Q J Exp Psychol (Hove), 62, pp.733~745 (2009)
- Estes WK, "Learning theory and intelligence", Am Psychol, 29, pp.740~749 (1974)
- Troyer AK, "Clustering and switching on verbal fluency: the effects of focal frontal- and temporal-lobe lesions", Neuropsychologia, 36, pp.499~504 (1998)
- Butters N, "Episodic and semantic memory: a comparison of amnesic and demented patients", J Clin Exp Neuropsychol, 9, pp.479~497 (1987)
- Ober BA, "Retrieval from semantic memory in Alzheimer-type dementia", J Clin Exp Neuropsychol, 8, pp.75~92 (1986)
- Troyer AK, "Normative data for clustering and switching on verbal fluency tasks", J Clin Exp Neuropsychol, 22, pp.370~378 (2000)
- Birn RM, "Neural systems supporting lexical search guided by letter and semantic category cues: a self-paced overt response fMRI study of verbal fluency", Neuroimage, 49, pp.1099~1107 (2010)
- Henry JD, "A meta-analytic review of verbal fluency performance following focal cortical lesions", Neuropsychology, 18, pp.284~295 (2004)
- Iudicello JE, "Cognitive mechanisms of switching in HIV-associated category fluency deficits", J Clin Exp Neuropsychol, 30, pp.797~804 (2008)
- Taler V, "Language performance in Alzheimer's disease and mild cognitive impairment: a comparative review", J Clin Exp Neuropsychol, 30, pp.501~556 (2008)
- 최현주, "경도 알츠하이머형 치매 환자의 범주유창성 과제에서의 범주특정적 손상 특징", Communication Sciences and Disorders, 15(4), pp.572~580 (2010), 한국언어청각임상학회
- Tröster AI, "A comparison of the category fluency deficits associated with Alzheimer's and Huntington's disease", Brain Lang, 37, pp.500~513 (1989)
- Troyer AK, "Clustering and switching on verbal fluency tests in Alzheimer's and Parkinson's disease", J Int Neuropsychol Soc, 4, pp.137~143 (1998)
- Weakley A, "Analysis of verbal fluency ability in Alzheimer's disease: the role of clustering, switching and semantic proximities", Arch Clin Neuropsychol, 29, pp.256~268 (2014)
- Lambon Ralph MA, "Semantic memory is impaired in both dementia with Lewy bodies and dementia of Alzheimer's type: a comparative neuropsychological study and literature review", J Neurol Neurosurg Psychiatry, 70, pp.149~156 (2001)
- Laukka EJ, "Similar patterns of cognitive deficits in the preclinical phases of vascular dementia and Alzheimer's disease", J Int Neuropsychol Soc, 10, pp.382~391 (2004)
- De Jager CA, "Sensitivity and specificity of neuropsychological tests for mild cognitive impairment, vascular cognitive impairment and Alzheimer's disease", Psychol Med, 33, pp.1039~1050 (2003)
- Bayles KA, "Generative naming in Parkinson disease patients", J Clin Exp Neuropsychol, 15, pp.547~562 (1993)
- Cummings JL, "Alzheimer's disease and Parkinson's disease: comparison of speech and language alterations", Neurology, 38, pp.680~684 (1988)
- Gomez RG, "Using verbal fluency to detect very mild dementia of the Alzheimer type", Arch Clin Neuropsychol, 21, pp.771~775 (2006)
- 박재설, "혈관성 치매와 알츠하이머형 치매의 언어 유창성 비교: 군집화와 전환", Communication Sciences and Disorders, 11(3), pp.99~112 (2006), 한국언어청각임상학회
- 최현주, "기억형 경도인지장애 환자의 의미적 측면에서의 언어장애 특성", Dementia and Neurocognitive Disorders(대한치매학회지), 12(2), pp.33~40 (2013), 대한치매학회[DOI]
- 김해윤, "기억성 경도인지장애와 혈관성 경도인지장애의 구어 유창성 저하 양상 비교", Communication Sciences and Disorders, 20(4), pp.587~595 (2015), 한국언어청각임상학회
- Kim C, "A comparison of the Controlled Oral Word Association Test performances between amnestic multi-domain MCI and MCI in Parkinson's disease", Korean J Psychol Annu Conf, 2013, pp.234~235 (2013)
- Nutter-Upham KE, "Verbal fluency performance in amnestic MCI and older adults with cognitive complaints", Arch Clin Neuropsychol, 23, pp.229~241 (2008)
- Jung IK, "A study of standardization of Korean form of Geriatric Depression Scale(KGDS", J Korean Geriatr Psychiatry, 1, pp.61~72 (1997)
- Won CW, "The development of Korean activities of daily living(K-ADL) and Korean instrumental activities of daily living(K-IADL) scale", J Korean Geriatr Soc, 6, pp.107~120 (2002)
- Hughes CP, "A new clinical scale for the staging of dementia", Br J Psychiatry, 140, pp.566~572 (1982)
- Kang Y, "A validity study on the Korean Mini-Mental State Examination (K-MMSE) in dementia patients", J Korean Neurol Assoc, 15, pp.300~308 (1997)
- 강연욱, "K-MMSE(Korean-Mini Mental State Examination)의 노인 규준 연구", 한국심리학회지:일반, 25(2), pp.1~12 (2006), 한국심리학회
- Kang Y, "Seoul Neuropsychological Screening Battery II", Human Brain Research & Consulting Co, ~ (2012)
- Christensen KJ, "A cognitive battery for dementia: development and measurement characteristics", J Consult Clin Psychol, 3, pp.168~174 (1991)
- Hwang S, "Korean Wechsler Adult Intelligence Scale IV", Korea Psychology Co. Ltd, ~ (2012)
- Weakley A, "Analysis of verbal fluency ability in amnestic and non-amnestic mild cognitive impairment", Arch Clin Neuropsychol, 28, pp.721~731 (2013)
- Raoux N, "Clustering and switching processes in semantic verbal fluency in the course of Alzheimer's disease subjects: results from the PAQUID longitudinal study", Cortex, 44, pp.1188~1196 (2008)
- Alexopoulos P, "Progression to dementia in clinical subtypes of mild cognitive impairment", Dement Geriatr Cogn Disord, 22, pp.27~34 (2006)
- Kawas C, "Age-specific incidence rates of Alzheimer's disease: the Baltimore Longitudinal Study of Aging", Neurology, 54, pp.2072~2077 (2000)
- Sackett PR, "A cautionary note on the effects of range restriction on predictor intercorrelations", J Appl Psychol, 92, pp.538~544 (2007)
- 성지은, "실어증 환자의 단기기억 및 작업기억용량과 실어증 중증도 및 문장처리와의 상관", Communication Sciences and Disorders, 15(3), pp.285~297 (2010), 한국언어청각임상학회
