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논문KCI 등재

의미 구어유창성 과제의 실시시간에 따른 경도인지장애 하위유형의 변별력

Discriminating Subtypes of Mild Cognitive Impairment according to Performance on Semantic Verbal Fluency Tasks with Different Administration Time

김수련
한국청각언어재활학회 (Korean Academy of Audiology)|2018.01|Audiology and Speech Research|제14권 제1호|pp. 48-54

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Mild cognitive impairment경도인지장애의미 구어유창성과제 실시시간집단 변별력.Semantic verbal fluency taskAdministration timeDiscriminant power.

초록

Purpose: Semantic (e.g., animal category) verbal fluency (SVF) tasks are widely utilized to measure subtle cognitive and language impairment caused by aging and neurological diseases. Mild cognitive impairment (MCI) regarded as transitional stage in aging with increased risk of incident dementia might show differential performances on SVF tasks according to MCI subtypes and different administration time. Methods: Three MCI subtypes of amnestic single-domain MCI (asMCI), amnestic multi-domain MCI (amMCI), non-amnestic MCI (non-aMCI), and age- and education-matched normal elderly (NE) participated in this study. Both the SVF tasks with 60- and 30-second administration time were conducted to four groups. Results: In 60-second SVF tasks, patients with amMCI and non-aMCI exhibited significantly lower performances than NE, but asMCI did not. In contrast, no significant differences were observed in 30-second SVF tasks between the groups. In receiver operating characteristics (ROC) curve analysis, 60-second SVF task showed fair discriminant power between amMCI and NE [area under ROC curve (AUC) = 0.779] as well as between non-aMCI and NE (AUC = 0.733). Conclusion: The results indicated that subtle cognitive decline of MCI might not be revealed during short administration time because automatic access for lexico-semantic process during the initial phase of SVF task is relatively preserved. The present study suggests that 60-second SVF tasks are useful to differentiate amMCI and non-aMCI groups from NE, but not asMCI.

Abstract

Purpose: Semantic (e.g., animal category) verbal fluency (SVF) tasks are widely utilized to measure subtle cognitive and language impairment caused by aging and neurological diseases. Mild cognitive impairment (MCI) regarded as transitional stage in aging with increased risk of incident dementia might show differential performances on SVF tasks according to MCI subtypes and different administration time. Methods: Three MCI subtypes of amnestic single-domain MCI (asMCI), amnestic multi-domain MCI (amMCI), non-amnestic MCI (non-aMCI), and age- and education-matched normal elderly (NE) participated in this study. Both the SVF tasks with 60- and 30-second administration time were conducted to four groups. Results: In 60-second SVF tasks, patients with amMCI and non-aMCI exhibited significantly lower performances than NE, but asMCI did not. In contrast, no significant differences were observed in 30-second SVF tasks between the groups. In receiver operating characteristics (ROC) curve analysis, 60-second SVF task showed fair discriminant power between amMCI and NE [area under ROC curve (AUC) = 0.779] as well as between non-aMCI and NE (AUC = 0.733). Conclusion: The results indicated that subtle cognitive decline of MCI might not be revealed during short administration time because automatic access for lexico-semantic process during the initial phase of SVF task is relatively preserved. The present study suggests that 60-second SVF tasks are useful to differentiate amMCI and non-aMCI groups from NE, but not asMCI.

참고문헌 (38)

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