PCR로 확인한 PML-RARA와 BCR-ABL1 재배열이 동시에 동반된 급성전골수구백혈병 1예
A Case of Acute Promyelocytic Leukemia with Co-existence of BCR-ABL1 and PML-RARA Rearrangements Detected by PCR
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초록
급성전골수구백혈병은 PML-RARA 유전자 이상과 특징적인 형태를 가진 급성 골수성백혈병의 한 종류이다. BCR-ABL1 유전자 이상은 주로 만성골수성백혈병 환자에게서 발견되는 유전자 이상이지만 성인 급성림프모구백혈병이나 드물게 급성골수성백혈병 환자에게서도 발견이 된다. 그러나 급성전골수구백혈병에서 발견되는 경우는 매우 드물다. 이에 저자들은 PML-RARA와 BCR-ABL1이 동반된 급성전골수구백혈병 1예를 경험하였기에 보고하는 바이다.
Abstract
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) characterized by PML-RARA fusion and specific morphology. The BCR-ABL1 rearrangement is mainly observed in patients with chronic myeloid leukiemia (CML). However, it is also found in patients with acute lymphoblastic leukemia (ALL) and in a few patients with AML. However, it is very rarely observed in patients with APL. Here, we report a case of APL with t(15;17) and co-existence of PML-RARA and BCR-ABL1. Further study with more cases is warranted to find the right treatment and prognostic significance.
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