Recent Seroprevalence of Anti-hepatitis A IgG in the Korean Population: a Large, Population-based Study
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Background: Because there is limited recent information on this topic, this study investigated the seroprevalence of anti-hepatitis A virus (HAV) immunoglobulin G (IgG) in the South Korean population in 2015–2017. Methods: Anti-HAV IgG seroprevalence data were obtained from the laboratory information system of Green Cross Laboratories, one of the largest referral laboratories in South Korea. Results: During the three-year study period, we obtained test results from 240,840 individuals (124,353 men and 116,487 women) from 1,348 hospitals and local clinics throughout South Korea. The median (range) age of subjects was 38.0 (18.0–97.2) years. The annual seroprevalence of anti-HAV IgG was 53.3%, 53.0%, and 53.1% in 2015, 2016, and 2017, respectively. The median age differed among geographic regions and anti-HAV seroprevalence differed among age groups and geographic regions (P<0.0001). Subjects in their 20’s had a significantly lower rate of anti-HAV IgG-positivity than subjects in their 10’s (odds ratio, [OR] 0.74, 95% CI, 0.69–0.78, P<0.0001), while other age groups had higher rates. Multivariable-adjusted logistic regression analysis showed that women and subjects living in Inchoen, Sejong city, Gangwon province, Gwangju, and North Jeolla province were more likely to be immune to HAV compared to subjects living in Seoul (OR >1.0, P<0.05). Conclusions: This study provides basic information about the recent seroprevalence of anti-HAV IgG in the Korean population and contributes to identifying groups at high risk of an HAV epidemic.
Abstract
Background: Because there is limited recent information on this topic, this study investigated the seroprevalence of anti-hepatitis A virus (HAV) immunoglobulin G (IgG) in the South Korean population in 2015–2017. Methods: Anti-HAV IgG seroprevalence data were obtained from the laboratory information system of Green Cross Laboratories, one of the largest referral laboratories in South Korea. Results: During the three-year study period, we obtained test results from 240,840 individuals (124,353 men and 116,487 women) from 1,348 hospitals and local clinics throughout South Korea. The median (range) age of subjects was 38.0 (18.0–97.2) years. The annual seroprevalence of anti-HAV IgG was 53.3%, 53.0%, and 53.1% in 2015, 2016, and 2017, respectively. The median age differed among geographic regions and anti-HAV seroprevalence differed among age groups and geographic regions (P<0.0001). Subjects in their 20’s had a significantly lower rate of anti-HAV IgG-positivity than subjects in their 10’s (odds ratio, [OR] 0.74, 95% CI, 0.69–0.78, P<0.0001), while other age groups had higher rates. Multivariable-adjusted logistic regression analysis showed that women and subjects living in Inchoen, Sejong city, Gangwon province, Gwangju, and North Jeolla province were more likely to be immune to HAV compared to subjects living in Seoul (OR >1.0, P<0.05). Conclusions: This study provides basic information about the recent seroprevalence of anti-HAV IgG in the Korean population and contributes to identifying groups at high risk of an HAV epidemic.
참고문헌 (15)
- Lemon SM, "Type A viral hepatitis : A summary and update on the molecular virology, epidemiology, pathogenesis and prevention", J Hepatol, 68, pp.167~184 (2018)
- GBD 2013 Mortality and Causes of Death Collaborators, "Global, regional, and national age-sex speciflc all-cause and cause-speciflc mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013", Lancet, 385, pp.117~171 (2015)
- Yoon JG, "Seroprevalence and disease burden of acute hepatitis A in adult population in South Korea", PLoS One, 12, pp.e0186257~ (2017)
- "Changing patterns of hepatitis A virus infection in Korea. Public Health Weekly Report" (2008)[URL]
- 이현주, "Seroepidemiology of Hepatitis A in Korea: Changes over the Past 30 Years", Journal of Korean Medical Science, 26(6), pp.791~796 (2011), 대한의학회
- "2017 Infectious Diseases Surveillance Yearbook" (2018)[URL]
- "KOrean Statistical Information Service. Population density (based on Population and Housing Census)"[URL]
- 이안나, "최근 4년 동안 전국의료기관에서 의뢰된 A형 간염바이러스 혈청 표지자 검사 결과에 대한 역학 분석", Annals of Laboratory Medicine, 29(6), pp.563~569 (2009), 대한진단검사의학회
- 이동훈, "A nationwide seroprevalence of total antibody to hepatitis A virus from 2005 to 2009: age and area-adjusted prevalence rates", Clinical and Molecular Hepatology, 17(1), pp.44~50 (2011), 대한간학회
- Cho SE, "Seroepidemiology of hepatitis A in South Korea : a nationwide study by the Eone Reference Laboratory", J Epidemiol, 23, pp.270~274 (2013)
- Gripenberg M, "Changing sero-epidemiology of hepatitis A in Asia Paciflc countries : a systematic review", Int J Infect Dis, 68, pp.13~17 (2018)
- Wang H, "Changing epidemiological characteristics of hepatitis A and warning of Anti-HAV immunity in Beijing, China : a comparison of prevalence from 1990 to 2017", Hum Vaccin Immunother, 15, pp.420~425 (2019)
- Chen Y, "Waning of anti-HAV immunity in Shijiazhuang prefecture, Hebei province, China : a comparison of seroprevalence between 1992 and 2011", Vaccine, 32, pp.6227~6232 (2014)
- "VPD surveillance manual enhancing surveillance: Chapter 19"[URL]
- Choe YJ, "Trends in infectious disease mortality, South Korea, 1983-2015", Emerg Infect Dis, 24, pp.320~327 (2018)