A nationwide seroprevalence of total antibody to hepatitis A virus from 2005 to 2009: age and area-adjusted prevalence rates
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Background/Aims: Recent outbreak of hepatitis A in Korea is clearly related to the epidemiological shift of hepatitis A virus (HAV). However, nationwide seroprevalence data have been limited. This study estimated the nationwide, age- and area-adjusted anti-HAV prevalence from 2005 to 2009. Methods: Retrospective analysis of the results of total anti-HAV test in 25,140 cases which were requested by 1,699 medical institutions throughout the nation to Seoul Clinical Laboratory from Jan. 1 2005 to Dec. 31 2009 was performed. The estimated seroprevalence was adjusted by area and age of the standard population based on the 2005 Census data from Korea National Statistical Office. Results: The area-adjusted anti-HAV prevalence in the children younger than 10 years were 33.4% in 2005 and 69.9% in 2009. The most susceptible age groups to HAV infection during the last 5 years were teenagers and the young adults in their age of twenties. The area-adjusted seroprevalence in 2009 were 11.9% in the age group of 20-29 years, 23.4% in the age group of 10-19 years, 48.4% in the age group of 30-39 years. The population in 40-49 years showed geographically different seroprevalence with the lowest rate in Seoul (80%). Conclusions: The most susceptible age group to HAV infection is 10-29 years, while the young children less than 10 years showed about 70% seropositivity. The changing seroepidemiology should be monitored continuously for the proper vaccination and patient care.
Abstract
Background/Aims: Recent outbreak of hepatitis A in Korea is clearly related to the epidemiological shift of hepatitis A virus (HAV). However, nationwide seroprevalence data have been limited. This study estimated the nationwide, age- and area-adjusted anti-HAV prevalence from 2005 to 2009. Methods: Retrospective analysis of the results of total anti-HAV test in 25,140 cases which were requested by 1,699 medical institutions throughout the nation to Seoul Clinical Laboratory from Jan. 1 2005 to Dec. 31 2009 was performed. The estimated seroprevalence was adjusted by area and age of the standard population based on the 2005 Census data from Korea National Statistical Office. Results: The area-adjusted anti-HAV prevalence in the children younger than 10 years were 33.4% in 2005 and 69.9% in 2009. The most susceptible age groups to HAV infection during the last 5 years were teenagers and the young adults in their age of twenties. The area-adjusted seroprevalence in 2009 were 11.9% in the age group of 20-29 years, 23.4% in the age group of 10-19 years, 48.4% in the age group of 30-39 years. The population in 40-49 years showed geographically different seroprevalence with the lowest rate in Seoul (80%). Conclusions: The most susceptible age group to HAV infection is 10-29 years, while the young children less than 10 years showed about 70% seropositivity. The changing seroepidemiology should be monitored continuously for the proper vaccination and patient care.
참고문헌 (18)
- Cheol-In Kang, "Incidence and Seroprevalence of Hepatitis A Virus Infections among Young Korean Soldiers", Journal of Korean Medical Science, 22(3), pp.546~548 (2007), 대한의학회
- Kim YJ, "Increasing incidence of hepatitis A in Korean adults", Intervirology, 53, pp.10~14 (2010)
- 이태희, "대전 서부와 인근 충남지역에서 발생한 급성 A형 간염의 임상양상: 단일기관 경험", 대한소화기학회지, 47(2), pp.136~143 (2006), 대한소화기학회
- "Korean J Hepatol", 1999, 4~
- 송영봉, "한국인 건강검진자에서 연령 특이적 A형간염바이러스 항체 혈청 양성률대한간학회지 제 13 권 제 1 호 2007 ; 27-33", Clinical and Molecular Hepatology, 13(1), pp.27~33 (2007), 대한간학회
- Hong WS, "Seroepilemiology of type A and type B hepatitis in Seoul area", Korean J Intern Med, 25, pp.19~26 (1982)
- 김태엽, "서울과 경기지역 두 병원의 최근 A형간염 항체 양성률에 대한 비교 조사", Clinical and Molecular Hepatology, 13(3), pp.363~369 (2007), 대한간학회
- Amela C, "Martinez-Navarro F. Trends in hepatitis A virus infection with reference to the process of urbanization in the greater Madrid area (Spain)", Eur J Epidemiol, 11, pp.569~573 (1995)
- Kremastinou J, "The changing epidemiologic pattern of hepatitis A infection in urban Greece", Am J Epidemiol, 120, pp.703~706 (1984)
- Schwartz E, "The prevalence of hepatitis A antibodies among Israeli travellers and the economic feasibility of screening before vaccination", Int J Epidemiol, 27, pp.118~120 (1998)
- Barzaga BN, "Hepatitis A shifting epidemiology in South-East Asia and China", Vaccine, 18(1), pp.61~64 (2000)
- Tufenkeji H, "Hepatitis A shifting epidemiology in the Middle East and Africa", Vaccine, 18(1), pp.65~67 (2000)
- Tanaka J, "Hepatitis A shifting epidemiology in Latin America", Vaccine, 18(1), pp.57~60 (2000)
- Saha SK, "Community-based cross-sectional seroprevalence study of hepatitis A in Bangladesh", World J Gastroenterol, 15, pp.4932~4937 (2009)
- Ki MR, "Economic analysis of vaccination and development of guidelines for control of hepatitis A virus infection, and epidemiologic analysis and development of control strategy of hepatitis C virus infection", ~ (2009)
- 김주일, "Factors influencing the severity of acute viral hepatitis A", Clinical and Molecular Hepatology, 16(3), pp.295~300 (2010), 대한간학회
- Daniels D, "Centers for Disease Control and Prevention (CDC). Surveillance for acute viral hepatitis - United States, 2007", MMWR Surveill Summ, 58, pp.1~27 (2009)
- Saab S, "A simple cost-decision analysis model comparing two strategies for hepatitis A vaccination", Am J Med, 109, pp.241~244 (2000)