Age-Specific Reference Values of Anti-Müllerian Hormone in Korean Women with Normal Menstruation: Time Trend and Clinical Suitability (2015–2021)
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Anti-Müllerian hormone (AMH) levels can be affected by various factors, including age, lifestyle, and test method. This study aimed to review the time trend of AMH levels and the clinical suitability of current age-specific AMH reference values in Korean women. Population-based data of AMH levels, collected from 2015 to 2021 at a clinical laboratory, in Korean women aged 20–49 year with normal menstruation were evaluated (N=19,032 for Gen II assay [Beckman Coulter, USA]; N=14,497 for Access assay [Beckman Coulter, USA]). We found significant differences of AMH levels over time measured using the Gen II assay, but not those assessed by the Access assay. Based on current age-specific reference values, the AMH levels in Korean women with normal menstruation were considered relatively low in the groups at both age extremes (late 20s and late 40s). The AMH levels of Korean women did not show any time trends, except for the influence of the test method. We found that in the case of the Gen II assay, current age-specific AMH reference values, based on an AMH-age regression model, may not be clinically suitable for age groups at both extremes. Therefore, we established new age-specific AMH reference values measured using the Access assay for the general population.
Abstract
Anti-Müllerian hormone (AMH) levels can be affected by various factors, including age, lifestyle, and test method. This study aimed to review the time trend of AMH levels and the clinical suitability of current age-specific AMH reference values in Korean women. Population-based data of AMH levels, collected from 2015 to 2021 at a clinical laboratory, in Korean women aged 20–49 year with normal menstruation were evaluated (N=19,032 for Gen II assay [Beckman Coulter, USA]; N=14,497 for Access assay [Beckman Coulter, USA]). We found significant differences of AMH levels over time measured using the Gen II assay, but not those assessed by the Access assay. Based on current age-specific reference values, the AMH levels in Korean women with normal menstruation were considered relatively low in the groups at both age extremes (late 20s and late 40s). The AMH levels of Korean women did not show any time trends, except for the influence of the test method. We found that in the case of the Gen II assay, current age-specific AMH reference values, based on an AMH-age regression model, may not be clinically suitable for age groups at both extremes. Therefore, we established new age-specific AMH reference values measured using the Access assay for the general population.
참고문헌 (10)
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