The regulatory effect of AST cream on atopic dermatitis-like skin disease.
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
In this study, we investigated an inhibitory effect of AST cream on atopic dermatitis (AD) using a 2,4-dinitrochlorobenzene-induced AD murine model. Topical treatment with AST cream ameliorated the severity of AD-like lesional skin through decreases in infiltration of inflammatory cells and time of scratching behaviors. Also, AST cream reduced histamine and IgE levels in serum. The protein levels of IL-4 and IL-6 in AD-like lesional skin were suppressed by AST cream. These findings suggest that AST cream would be an alternative therapeutic agent for AD-like skin diseases.
Abstract
In this study, we investigated an inhibitory effect of AST cream on atopic dermatitis (AD) using a 2,4-dinitrochlorobenzene-induced AD murine model. Topical treatment with AST cream ameliorated the severity of AD-like lesional skin through decreases in infiltration of inflammatory cells and time of scratching behaviors. Also, AST cream reduced histamine and IgE levels in serum. The protein levels of IL-4 and IL-6 in AD-like lesional skin were suppressed by AST cream. These findings suggest that AST cream would be an alternative therapeutic agent for AD-like skin diseases.
참고문헌 (18)
- Belloni Fortina A, "Antibiotic therapy in the management of atopic dermatitis", G Ital Dermatol Venereol, 150(3), pp.321~325 (2015)
- Choi JK, "Rutin suppresses atopic dermatitis and allergic contact dermatitis", Exp Biol Med(Maywood), 238(4), pp.410~417 (2013)
- Han NR, "Regulatory effects of chrysophanol, a bioactive compound of AST2017 01 in a mouse model of 2, 4 dinitrofluorobenzene induced atopic dermatitis", Int Immunopharmacol, 62, pp.220~226 (2018)
- Kim HY, "The ameliorative effect of AST2017 01 in an ovalbumin induced allergic rhinitis animal model", Inflamm Res, 68, pp.387~395 (2019)
- Klein P, "An Evidence Based Review of the Efficacy of Antihis tamines in Relieving Pruritus in atopic dermatitis", Arch Dermatol, 135, pp.1522~1525 (1999)
- Klonowska J, "New Cytokines in the Pathogenesis of Atopic Dermatitis New Therapeutic Targets", Int J Mol Sci, 19(10), pp.3086~ (2018)
- Konda D, "Serotonin and interleukin 6 : Association with pruritus severity, sleep quality and depression severity in Prurigo Nodularis", Asian J Psychiatr, 17, pp.24~28 (2015)
- Lee HH, "Anti cancer effect of Cordyceps militaris in human colorectal carcinoma RKO cells via cell cycle arrest and mitochondrial apoptosis", Daru, 23, pp.35~ (2015)
- Lowa A, "Alternatives to animal testing in basic a nd preclinical research of atopic dermatitis", Exp Dermatol, 27, pp.476~483 (2018)
- Matsui K, "Topical Application of Josamycin Inhibits Development of Atopic Dermatitis Like Skin Lesions in NC", Nga Mice, 2017, pp.20, 38~47
- Navarini AA, "Interrupting IL-6-receptor signaling improves atopic dermatitis but associates with bacterial superinfection", J Allergy Clin Immunol, 128(5), pp.1128~1130 (2011)
- Ng TB, "Pharmacological actions of Cordyceps, a prized folk medicine", J Pharm Pharmacol, 57, pp.1509~1519 (2005)
- 정귀택, "소리쟁이 추출물의 항균 및 항산화 활성에 관한 연구", Korean Chemical Engineering Research(HWAHAK KONGHAK), 44(1), pp.81~86 (2006), 한국화학공학회
- Paton DM, "Dupilumab : human monoclonal antibody against I L 4Ra for moderate to severe atopic dermatitis", Drugs Today, 53, pp.477~487 (2017)
- Ryu KJ, "Therapeutic effects of Artemisia scoparia Waldst. et Kitaib in a murine model of atopic dermatitis", Clin Exp Dermatol, 43(7), pp.798~805 (2018)
- Venekamp RP, "Are topical antibiotics an alternative to oral antibiotics for children with acute otitis media and ear discharge?", BMJ, 352, pp.i308~ (2016)
- Weber MB, "Evaluating the relation between pruritus, serum IgE levels and severity of clinical manifestations in atopic dermatitis patients", An Bras Dermatol, 80, pp.245~248 (2005)
- Wong LS, "Inflammatory and Noninflammatory Itch : Implications in Pathophysiology Directed Treatments", Int J Mol Sci, 18(7), pp.1485~ (2017)