Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model
1
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Jeechool-Whan (JW) is a prescription of Ponciri Fructus Immaturus and Atractylodis Rhizoma Alba and improves the functions of the stomach and the spleen. Although it is said in Korean Medicine that the spleen and the stomach are the roots of the body's resistance, the meaning of 'improving the spleen and the stomach' is very comprehensive. Moreover, there are lots of drugs that are said to improve the spleen and the stomach, and the number of prescriptions using these drugs is huge. In this study, we focused on the new effect and mechanism of the JW on the ovalbumin (OVA)-induced allergic rhinitis (AR) model. The increased number of rubs and the increased levels of IgE and histamine in the OVA-sensitized mice were inhibited by JW administration. The balance of Th1/Th2 cytokine level was regulated by JW administration. The levels inflammatory proteins were decreased by JW administration in the nasal mucosa of the OVA-sensitized mice. Eosinophils and mast cells infiltration increased by OVA-sensitization was also decreased in the JW-administered mice. In addition, JW inhibited caspase-1 activity in the same nasal mucosa tissue. In activated human mast cells, JW inhibited the receptor interacting protein-2, IκB kinase-β, nuclear factor-κB/Rel A, and caspase-1 activation. In conclusion, this study will be support the clear understanding of the concept of the spleen and the stomach in traditional Korean medicine as well as for a possibility of finding a cure for this AR in traditional medical treatments.
Abstract
Jeechool-Whan (JW) is a prescription of Ponciri Fructus Immaturus and Atractylodis Rhizoma Alba and improves the functions of the stomach and the spleen. Although it is said in Korean Medicine that the spleen and the stomach are the roots of the body's resistance, the meaning of 'improving the spleen and the stomach' is very comprehensive. Moreover, there are lots of drugs that are said to improve the spleen and the stomach, and the number of prescriptions using these drugs is huge. In this study, we focused on the new effect and mechanism of the JW on the ovalbumin (OVA)-induced allergic rhinitis (AR) model. The increased number of rubs and the increased levels of IgE and histamine in the OVA-sensitized mice were inhibited by JW administration. The balance of Th1/Th2 cytokine level was regulated by JW administration. The levels inflammatory proteins were decreased by JW administration in the nasal mucosa of the OVA-sensitized mice. Eosinophils and mast cells infiltration increased by OVA-sensitization was also decreased in the JW-administered mice. In addition, JW inhibited caspase-1 activity in the same nasal mucosa tissue. In activated human mast cells, JW inhibited the receptor interacting protein-2, IκB kinase-β, nuclear factor-κB/Rel A, and caspase-1 activation. In conclusion, this study will be support the clear understanding of the concept of the spleen and the stomach in traditional Korean medicine as well as for a possibility of finding a cure for this AR in traditional medical treatments.
참고문헌 (54)
- Albelda SM, "Endothelial and epithelial cell adhesion molecules", Am J Respir Cell Mol Biol, 4, pp.195~203 (1991)
- Bach JF, "The effect of infections on susceptibility to autoimmune and allergic diseases", N Engl J Med, 347, pp.911~920 (2002)
- Bournazou I, "Inhibition of eosinophil migration by lactoferrin", Immunol Cell Biol, 88, pp.220~223 (2010)
- Bousquet J, "Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA (2) LEN and Allergen)", Allergy, 86, pp.8~160 (2008)
- Calderon E, "A possible role for adhesion molecules in asthma", J Allergy Clin Immunol, 90, pp.852~865 (1992)
- Chang ML, "The influence of Chinese traditional medicine on the production and activity of interleukin 1 (IL-1)", Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi, 26, pp.15~24 (1993)
- Cha WS, "Historical difference between traditional Korean medicine and traditional Chinese medicine", Neurol Res, 29, pp.S5~S9 (2007)
- Chin AI, "Involvement of receptor-interacting protein 2 in innate and adaptive immune responses", Nature, 416, pp.190~194 (2002)
- Choi K, "Sasang constitutional types can act as a risk factor for insulin resistance", J.Diabetes Res Clin Pract, 91, pp.57~60 (2011)
- Eum HA, "Anti-inflammatory activity of CML-1: an herbal formulation", Am J Chin Med, 33, pp.29~40 (2005)
- Fuentes-Beltran A, "Chemokine CC-ligand 5 production and eosinophil activation into the upper airways of aspirin-sensitive patients", Clin Exp Allergy, 39, pp.491~499 (2009)
- Fukui N, "Peroxisome proliferator-activated receptor gamma negatively regulates allergic rhinitis in mice", Allergol Int, 58, pp.247~253 (2009)
- Grzegorczyk J, "Increased apoptosis of peripheral blood mononuclear cells in patients with perennial allergic asthma", rhinitis : relation to serum markers of apoptosis, 2002, pp.11, 225~233
- Gupta S, "Intra-alveolar macrophage-inflammation peptide 2 induces rapid neutrophil localization in the lung", Am J Respir Cell Mol Biol, 15, pp.656~663 (1996)
- Guzman J, "ICAM-1 and integrin expression on isolated human alveolar type II pneumocytes", Eur Respir, 7, pp.736~739 (1994)
- Hellings PW, "Allergic rhinitis and its impact on otorhinolaryngology", Allergy, 61, pp.656~664 (2006)
- Hirota RJ, "Anti-inflammatory Effects of Limonene from Yuzu(Citrus junos Tanaka)Essential Oil on Eosinophils", J Food Sci, 75, pp.87~92 (2010)
- Hong MH, "Atractylodes japonica Koidzumi Inhibits the Production of Proinflammatory Cytokines through Inhibition of the NF-kB", IkB Signal Pathway in HMC-1 Human Mast Cells, 2010, pp.33, 843~851
- Hosomi N, "Caspase-1 activity of stratum corneum and serum interleukin-18 level are increased in patients with Netherton syndrome", Br J Dermatol, 159, pp.744~746 (2008)
- Howarth PH, "Allergy, Principles and Practice. Vol. 2", pp.391~410 (2003), Mosby
- Inohara N, "Nunez G An induced proximity model for NF-kappa B activation in the Nod1", RICK and RIP signaling pathways, 2000, pp.275, 27823~27831
- Jeong HJ, "Yulda-hanso-tang attenuates the endotoxin-induced inflammatory cytokine production in peripheral blood mononuclear cells", Int J Neuro, 117, pp.1149~1165 (2007)
- Jeong HJ, "Activation of hypoxia-inducible factor-1 regulates human histidine decarboxylase expression", Cell Mol Life Sci, 66, pp.1309~1319 (2009)
- Jeong MY, "A combined extract of Cinnamomi Ramulus, Anemarrhenae Rhizoma and Alpiniae Officinari Rhizoma suppresses production of nitric oxide by inhibiting NF-kappaB activation in RAW 264.7 cells", Phytother Res, 22, pp.772~777 (2008)
- Johansson SG, "A revised nomenclature for allergy: an EAACI position statement from the EAACI nomenclature task force", Allergy, 56, pp.813~824 (2001)
- Kelsall B, "Getting to the guts of NOD2", Nature medicine, 11, pp.383~384 (2005)
- "2011", 1(1), 후마니타스 세포교정의학회
- Kobayashi K, "RICK", Rip2, Nature, pp.2002, 416[DOI]
- Kubo M, "Anti-inflammatory activities of 70% methanolic extract from Cinnamomi Cortex", Biol Pharm Bull, 19, pp.1041~1045 (1996)
- Lamkanfi M, "Caspases-Their role in Cell death and cell survival" (2003), Landes Bioscience and Kluwer Academic
- Lee SS, "Effects of Dexamethasone on the Expression of Transforming Growth Factor-b in the Mouse Model of Allergic Rhinitis", Laryngoscope, 117, pp.1323~1328 (2007)
- Makino T, "Effect of oral treatment of Perilla frutescens and its constituents on type-I allergy in mice", Biol Pharm Bull, 24, pp.1206~1209 (2001)
- Marlin SD, "Purified intercellular adhesion molecular-1 (ICAM-1) is a ligand for lymphocyte function associated antigen-1 (LFA-1)", Cell, 51, pp.813~819 (1987)
- Martinon F, "NLRs join TLRs as innate sensors of pathogens", Trends Immunol, 26, pp.447~454 (2005)
- Montefort S, "Leukocyte-endothelial adhesion molecules and their role in bronchial asthma and allergic rhinitis", Eur Respir J, 6, pp.1044~1054 (1994)
- Montuschi P, "Pharmacological modulation of the leukotriene pathway in allergic airway disease", Drug Discov Today, 12, pp.404~412 (2007)
- Mosmann TR, "Definition according to profiles of lymphokine activities and secreted proteins", J Immunol, 136, pp.2348~2357 (1986)
- Osakabe N, "Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in D-galactosamine (D-GalN)-sensitized mice", Free Radic Biol Med, 33, pp.798~806 (2002)
- Park SH, "Temperament and Character Profiles of Sasang Typology in an Adult Clinical Sample", Evid Based Complement Alternat Med, 2011, pp.794795~ (2011)
- Pawankar R, "Role of mast cells and basophils in chronic rhinosinusitis", Clin Allergy Immunol, 20, pp.93~101 (2007)
- Sanbongi C, "Rosmarinic acid inhibits lung injury induced by diesel exhaust particles", Free Radic Biol Med, 34, pp.1060~1069 (2003)
- Sarkar A, "ASC directs NF-B activation by regulating receptor interaction protein-2 (RIP2) caspase-1 interactions", J Immunol, 176, pp.4979~4986 (2006)
- Sato Y, "Protective effect of various extracts on crude drugs on skin injury induced by X-irradiation", Yakugaku Zasshi, 109, pp.113~118 (1989)
- Shin TY, "Inhibitory effect of mast cell-mediated immediate-type allergic reactions in rats by Perilla frutescens", Immunopharmacol Immunotoxicol, 22, pp.489~500 (2000)
- Skoner DP, "Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis", J allergy Clin Immunol, 108, pp.2~8 (2001)
- Smith SJ, "Dexamethasone inhibits maturation, cytokine production and Fc epsilon RI expression of human cord blood-derived mast cells", Clin Exp Allergy, 32, pp.906~913 (2002)
- Stutz A, "Inflammasomes : too big to miss", J Clin Invest, 119, pp.3502~3511 (2009)
- Tachibana H, "Identification of an inhibitor for interleukin 4-induced epsilon germline transcription and antigen specific IgE production in vivo", Biochem Biophys Res Commun, 280, pp.53~60 (2001)
- Takano H, "Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans", Exp Biol Med, 229, pp.247~254 (2004)
- Tosi MF, "Induction of ICAM-1 expression on human airway epithelial cells by inflammatory cytokines : Effects on neutrophils-epithelial cell adhesion", Am J Respir Cell Mol Biol, 7, pp.214~221 (1992)
- Whitcup SM, "Recent advances in ocular therapeutics", Int Ophthalmol Clin, 46, pp.1~6 (2006)
- Woschnagg C, "Eosinophil cationic protein(ECP)is processed during secretion", J Immunol, 183, pp.3949~3954 (2009)
- Yazdi AS, "Inflammatory caspases in innate immunity and inflammation", J Innate Immun, 2, pp.228~237 (2010)
- Yoo NJ, "Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1", Biochem Biophys Res Commun, 299, pp.652~658 (2002)
