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神朮散이 알레르기 비염 유발 흰쥐 모델에 미치는 영향

The Effect of Shinchulsan on the Rat Model with Allergic Rhinitis

조가원|황충연|허은선|배현진
대한한방안이비인후피부과학회 (The Korean Medicine Opthalmology&Otolaryngology&Dermatology Society)|2015.08|한방안이비인후피부과학회지 (The Journal of Korean Medicine Ophthalmology&Otorhinolaryngology&Dermatology)|제28권 제3호|pp. 76-87|DOI http://dx.doi.org/10.6114/jkood.2015.28.3.076

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키워드

Allergic RhinitisIL-4ShinchulsanOvalbuminTotal IgEEosinophil
주제분류한의학

초록

Objectives : Allergic rhinitis is highly increased in these days. We aimed to investigate therapeutic effect of Shinchulsan by observing changes in blood cells and the protein expression level of IL-4 in spleen of Sprague-Dawley(SD) rats with allergic rhinitis. Methods : Fifteen SD rats were divided into three groups: normal, control, and sample group. Allergic rhinitis was induced in the control and sample group by intraperitional and intranasal sensitization with 0.1% and 0.4% Ovalbumin solution. Then Shinchulsan was orally administered only to the sample group for 28 days, while the rats in the control group was given normal saline. Results : 1. Shinchulsan showed significantly decreased eosinophil level on the serum of the rat model. 2. Shinchulsan showed significantly decreased IgE level on the serum of the rat model. 3. Shinchulsan showed significantly decreased the protein expression levels of IL-4 in spleen of the rat model. 4. Shinchulsan had no hepatoxicity, according to AST and ALT on the serum. Conclusion : According to the above results, it is considered that Shinchulsan is helpful in treatment of allergic rhinitis.

Abstract

Objectives : Allergic rhinitis is highly increased in these days. We aimed to investigate therapeutic effect of Shinchulsan by observing changes in blood cells and the protein expression level of IL-4 in spleen of Sprague-Dawley(SD) rats with allergic rhinitis. Methods : Fifteen SD rats were divided into three groups: normal, control, and sample group. Allergic rhinitis was induced in the control and sample group by intraperitional and intranasal sensitization with 0.1% and 0.4% Ovalbumin solution. Then Shinchulsan was orally administered only to the sample group for 28 days, while the rats in the control group was given normal saline. Results : 1. Shinchulsan showed significantly decreased eosinophil level on the serum of the rat model. 2. Shinchulsan showed significantly decreased IgE level on the serum of the rat model. 3. Shinchulsan showed significantly decreased the protein expression levels of IL-4 in spleen of the rat model. 4. Shinchulsan had no hepatoxicity, according to AST and ALT on the serum. Conclusion : According to the above results, it is considered that Shinchulsan is helpful in treatment of allergic rhinitis.

참고문헌 (37)

  1. Korean Society of Otorhinolaryngology, "Otorhinolaryngology-Head and Neck Surgery 2", pp.1087~1105 (2009), Il Jo Gak
  2. National Health Insuarance Service, "Analysis of Health Insuarance expenses data for seasonal Allergic Rhinitis in the last five years(2008~2012)" (2013), National Health Insuarance Service
  3. An HY., "Clinical Otolaryngology Head and Neck Surgery", pp.120~ (2005), Koonja Publisher
  4. Roh SS, "Dermatology", pp.599~611 (2007), Il Jung Sa
  5. Hwang KS, "Sasang Contitutional Medical treatment for Allergic Rhinitis", J of Korean Medicine, 14(2), pp.414~417 (1993)
  6. Jin SM, "Taepyunghaemin Hwajegukbang", pp.8~11 (1964), Yeopungchulpansa
  7. 박정훈, "알레르기 비염 유발 생쥐에 대한 荊芥連翹湯의 iNOS 생성 억제 효과", 한방안이비인후피부과학회지, 25(1), pp.12~21 (2012), 대한한방안이비인후피부과학회
  8. 윤채성, "補中益氣湯加味方과 麻黃辛芎散 병용이 알레르기 비염 유발 흰쥐 모델에 미치는 영향", 한방안이비인후피부과학회지, 21(3), pp.111~123 (2008), 대한한방안이비인후피부과학회
  9. Gam CW, "The Clinical Study of Socheongryong-Tang on the Allergic Rhinitis", J East-West medicine, 26(2), pp.23~32 (2001)
  10. 안찬근, "溫肺湯이 알레르기 비염 유발 흰쥐 모델에 미치는 영향", 한방안이비인후피부과학회지, 20(3), pp.29~42 (2007), 대한한방안이비인후피부과학회
  11. 정진영, "通竅湯이 알레르기 비염 모델 흰 쥐에 미치는 영향", 한방안이비인후피부과학회지, 18(2), pp.36~50 (2005), 대한한방안이비인후피부과학회
  12. 양희연, "去痰補肺湯이 알레르기성 비염 모델 생쥐의 cytokine 변화에 미치는 영향", 한방안이비인후피부과학회지, 18(2), pp.28~35 (2005), 대한한방안이비인후피부과학회
  13. 주경옥, "白蒺藜가 알레르기 비염 유발 동물 모델에 미치는 영향", 한방안이비인후피부과학회지, 24(2), pp.28~34 (2011), 대한한방안이비인후피부과학회
  14. Skoner DP, "Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis", J Allergy Clin Immunol, 108, pp.S2~S8 (2001)
  15. Bellanti JA, "Allergic rhinitis update: epidemiology and natural history", Allergy Asthma Proc, 21, pp.367~370 (2000)
  16. Nathan RA, "The burden of allergic rhinitis", Allergy Asthma Proc, 28, pp.3~9 (2007)
  17. Min YK, "Otorhinolaryngology for primary care", pp.60~62 (2002), Iljokac
  18. 이종명, "알레르기비염의 진단과 치료", 대한내과학회지, 76(3), pp.268~273 (2009), 대한내과학회
  19. 한선숙, "알레르기 비염 환자에서 고주파 치료 효과의 주관적, 객관적 평가 : 12개월 추적 결과", 박사, 의학, pp.2008
  20. Jung KM, "Dongeui Pediatry", pp.577~579 (1990), Hanglim media
  21. Chae BY, "Korean Med Ophthalmol Otolaryngol Dermatol", pp.245~250 (1989), Jipmundang
  22. Kim GY, "Hwangjenaekyung Gyojugumguejip", pp.59~239 (1998), Il Jung Sa
  23. You WS, "HaganSamyuksseo", pp.74~81 (1994), Sungbosa
  24. Heo J, "Junggyo Donguibogam", pp.95~686 (2001), Hanmi book
  25. Heo J, "Donguibogam", pp.1073~1327 (2006), Donguibogamchulpans
  26. Shin MG, "Clinical application of Traditional herb", pp.40~47 (1986), Sungbosa
  27. Shin MG, "Clinical Traditional Herbalogy", pp.172~177 (1986), NamSanDang
  28. Kim DH, "Pharmacology of traditional oriental medicine", pp.116~125 (2010), Shinil Books
  29. Oh YU, "Effects of Samyootang and Shinchulsan extract on the contraction of isolated Guinea pig's trachea smooth muscle", J Korean Internal Medicine, 13(2), pp.84~94 (1992)
  30. Lee SH, "Effects of Oyootang and Shinchulsan extract on the contraction of isolated Guinea pig's trachea smooth muscle", J Korean Internal Medicine, 14(1), pp.1~16 (1993)
  31. Arthur C, "Ph.D. Medical Physiology", pp.446~455 (2002), ungdam Media
  32. Lee SC, "A Clinical Study of Provocation Test in Allergic Rhinitis", Inje Medicine, 11(1), pp.63~72 (1990)
  33. Kindt TJ, "Immunology", Epublic, pp.81~365 (2008)
  34. Abbas, Lichtman, "Basic immunology: functions and disorder of the immune system", pp.194~198 (2005), Bummunsa
  35. Bochner BS, "The role of adhesion molecules in human eosinophils and basophils recruitment", J Allergy ClinImmunol, 94, pp.38~47 (1994)
  36. Ohasho Y, "Serum level of interleukin-4 in patients with perennial allergic rhinitis during allergen specific immunology", Scand J Immunol, 43, pp.680~686 (1996)
  37. Choi BH, "Effects of the low level laser irradiation therapy on the ovalbumin-induced mouse model of allergic rhinitis", KyungHee Journal of the Institute of Oriental Medicine (2013)

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