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Protective effects of Hydro-alcoholic extract of the roots of Kasondi (Cassia occidentalis L.) against gentamicin-induced nephrotoxicity in albino Wistar rats

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Objectives:Cassia occidentalis L. is a weed belonging to the Caesalpiniaceae family. The root of this medicinal plant is used for the treatment of various ailments, including kidney diseases. The present study was aimed at evaluating the nephroprotective effects of HAE of the roots of Cassia occidentalis L. against gentamicin-induced renal toxicity in albino Wistar rats. Methods:The renal toxicity was induced by subcutaneous administration of gentamicin at 100 mg/kg in the rats belonging to the disease control and treatment groups from the 4th to the 8th day. The rats in the treatment group received HAE of the roots of Cassia occidentalis L. at 67 mg/kg b. w. orally for 8 days, while no treatment was given to the rats in the disease control and plain control groups. At the end of the experiment, renal biomarkers viz; s. creatinine, b. urea, and s. uric acid, were investigated. The histopathological examination of the kidney specimens was also carried out. Results:The results of the present study revealed that renal function biomarkers such as s. creatinine, b. urea, and s. uric acid were significantly reduced in the rats of the treatment group as compared to those of the disease control group. Moreover, the histoarchitecture reports of the treatment group’s kidney specimens showed significant improvements. Conclusion:The results suggested that the HAE of Cassia occidentalis L. roots promisingly prevented kidney injury in gentamicin-induced nephrotoxic rats. This effect might be due to improved clearance of gentamicin from the renal tubule and decreased generation of reactive oxygen species (ROS).

Abstract

Objectives:Cassia occidentalis L. is a weed belonging to the Caesalpiniaceae family. The root of this medicinal plant is used for the treatment of various ailments, including kidney diseases. The present study was aimed at evaluating the nephroprotective effects of HAE of the roots of Cassia occidentalis L. against gentamicin-induced renal toxicity in albino Wistar rats. Methods:The renal toxicity was induced by subcutaneous administration of gentamicin at 100 mg/kg in the rats belonging to the disease control and treatment groups from the 4th to the 8th day. The rats in the treatment group received HAE of the roots of Cassia occidentalis L. at 67 mg/kg b. w. orally for 8 days, while no treatment was given to the rats in the disease control and plain control groups. At the end of the experiment, renal biomarkers viz; s. creatinine, b. urea, and s. uric acid, were investigated. The histopathological examination of the kidney specimens was also carried out. Results:The results of the present study revealed that renal function biomarkers such as s. creatinine, b. urea, and s. uric acid were significantly reduced in the rats of the treatment group as compared to those of the disease control group. Moreover, the histoarchitecture reports of the treatment group’s kidney specimens showed significant improvements. Conclusion:The results suggested that the HAE of Cassia occidentalis L. roots promisingly prevented kidney injury in gentamicin-induced nephrotoxic rats. This effect might be due to improved clearance of gentamicin from the renal tubule and decreased generation of reactive oxygen species (ROS).

참고문헌 (39)

  1. Ronco C, "Acute kidney injury", The Lancet, 394(10212), pp.1949~1964 (2019)[DOI]
  2. Dachuri V, "Protective effects of traditional polyherbs on cisplatin-induced acute kidney injury cell model by inhibiting oxidative stress and MAPK signaling pathway", Molecules, 25(23), pp.5641~ (2020)[DOI]
  3. Levey AS, "Acute kidney injury", Annals of Internal Medicine, 167(9), pp.66~80 (2017)[DOI]
  4. Kellum JA, "Acute kidney injury", Nature Reviews Disease Primers, 7(1), pp.1~7 (2021)[DOI]
  5. Basile DP, "Pathophysiology of acute kidney injury", Comprehensive Physiology, 2(2), pp.1303~1353 (2012)[DOI]
  6. Rewa O, "Acute kidney injury : Epidemiology, outcomes and economics", Nature Reviews Nephrology, 10(4), pp.193~197 (2014)[DOI]
  7. Chinnappan SM, "Nephroprotective effect of herbal extract Eurycoma longifolia on paracetamol-induced nephrotoxicity in rats", Evid-Based Complementary and Alternative Medicine, 13, pp.1~6 (2019)[DOI]
  8. Randjelovic P, "Gentamicin nephrotoxicity in animals : Current knowledge and future perspectives", EXCLI Journal, 16, pp.388~399 (2017)[DOI]
  9. Boroushaki MT, "Reno-protective effect of Rheum turkestanicum against gentamicin-induced nephrotoxicity", Iranian Journal of Basic Medical Sciences, 22(3), pp.328~333 (2019)[DOI]
  10. "Standard Unani Medical Terminology", Central Council for Research in Unani Medicine, Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy, Ministry of Health & Family Welfare, Government of India, 238~ (2012)
  11. Javaid R, "Concept of kidney disorders & its treatment in Unani system of medicine", International Journal of Health Sciences and Research, 10(9), pp.290~295 (2020)
  12. Sina I., "Al-Qanoon fiʼl Tib, vol 2nd", pp.258~ (2010), Ejaz Publication House
  13. Pal S, "Extract and fraction of Cassia occidentalis L. (a synonym of Senna occidentalis) have osteogenic effects and prevent glucocorticoid-induced osteopenia", Journal of Ethnopharmacology, 10(235), pp.8~18 (2019)[DOI]
  14. Kabeeruddin M., "Makhzan al-Mufradat", pp.328~ (2014), Idara Kitab al-Shifa
  15. Jafri MA, "Hepatoprotective activity of leaves of Cassia occidentalis against paracetamol and ethyl alcohol intoxicant in rats", Journal of Ethanopharmacology, 6, pp.355~361 (1999)[DOI]
  16. Yadav JP, "Cassia occidentalis L.: A review on its ethnobotany, phytochemical and pharmacological profile", Fitoterapia, 81(4), pp.223~230 (2010)[DOI]
  17. Deepak Kumar, "Larvicidal Activity of<i>Cassia occidentalis<", i>(Linn.) against the Larvae of Bancroftian Filariasis Vector Mosquito<i>Culex quinquefasciatus<, Journal of Parasitology Research, pp.2014, 2014[DOI]
  18. Ntchapda F, "Diuretic and antioxidant activites of the aqueous extract of leaves of Cassia occidentalis (Linn.) in rats", Asian Pacific Journal of Tropical Medicine, 8(9), pp.685~693 (2015)[DOI]
  19. Al-Snafi AE, "The Therapeutic importance of Cassia occidentalis-An overview", Indian Journal of Pharmaceutical Sciences and Research, 5(3), pp.158~171 (2015)
  20. Singh VV, "Pharmacological and Phytochemical profile of Cassia occidentalis L : A review", Journal of Drug Delivery and Therapeutics, 6(5), pp.91~96 (2016)[DOI]
  21. Ghani N., "Khazain al-Adwiya", pp.1047~1049 (2011), Idara Kitab al-Shifa
  22. Khan MA., "Muhit-i-Azam, vol 4th", pp.190~191 (2018), Central council of Research in Unani Medicine, Ministry of Health & Family Welfare
  23. Saifuddin HS, "Unani Adwiya Mufarida", pp.226~227 (2013), Qaumi Council Bara-i-Farogh Urdu Zubaan
  24. Ansari AP, "Evaluation of chronic toxicity of Kushta Sammulfar(calx of Arsenic trioxide)", Journal of Xenobiotics, 3, pp.14~18 (2013)
  25. Fahamiyan N, "Nephroprotective activity of methanolic extract of Cumin melo Linn. in gentamicin-induced nephrotoxicity", International Journal of Drug Formulation and Research, 3(2), pp.40~53 (2012)
  26. Fulzele VB, "Comparative hepatoprotective activity of liv-52 and silymarine against hepatotoxicity induced by antiandrogen-bicalutamide in rats", International Journal of Pharmacy and Pharmaceutical Sciences, 4(3), pp.211~213 (2012)
  27. Bawakhan B, "A comparison between urea reduction ratio and urea kinetic model in assessing hemodialysis adequency in end stage renal disease", International Journal of Clinical Biochemistry and Research, 5(2), pp.263~267 (2018)[DOI]
  28. Hoste L, "Routine serum creatinine measurements : how well do we perform", BMC Nephrololgy, 16(21), pp.1~9 (2015)[DOI]
  29. Shaw H, "Psychological status and uric acid levels in oral lichen planus patients-A case control study", Indian J Dent Res, 31, pp.368~375 (2020)[DOI]
  30. Govindappa PK, "Effect of Withania somnifera on gentamicin-induced renal lesion in rats", Brazilian Journal of Pharmacognosy, 29, pp.234~240 (2019)[DOI]
  31. Luna LG., "Manual of Histologic Staining Method by Armed Forces Institute of Pathology", pp.12~33 (1968), Mc Graw Hill Book Company
  32. Alam S, "Concept of chronic kidney disease and its management in Unani medicine : A review", International Journal of Current Research, 7(12), pp.24785~24788 (2015)
  33. Rushd I, "Kitab al-Kulliyat", pp.112~113 (1980), Central Council of Research in Unani Medicine, Ministry of Health & Family Welfare
  34. Alam MA, "Nephroprotective effect and Unani Medicine : A Review", Journal of Nephrology & Therapeutics, 6(1), pp.1~3 (2016)[DOI]
  35. Arya V, "Antioxidant activity of organic and aqueous leaf extracts of Cassia occidentalis L. in relation to their phenolic content", Natural Product Research, 25(15), pp.1473~1479 (2011)[DOI]
  36. Gowrisri M, "Antioxidant and nephroprotective activities of Cassia occidentalis leaf extract against gentamicin-induced nephrotoxicity in rats", Research Journal of Pharmaceutical, Biological and Chemical Sciences, 3(3), pp.684~694 (2012)
  37. Naushad M, "Nephroprotective effect of Tukhm-e-Karafs (Apium graveolens L.) against Cisplatin-induced nephrotoxicity", Journal of Ayurveda and Integrative Medicine, pp.1~9 (2021)[DOI]
  38. Ansari AP, "Validation of Unani concept Abdāl-i-Adwiya (drug substitution) by physicochemical standardization and hepatoprotective activity of Aristolochia rotunda L. and its substitute Curcuma zedoaria Rosc. In albino Wistar rats", Journal of Complementary and Integrative Medicine (2021)[DOI]

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