히알루론산 나트륨과 카복시메틸셀룰로스 점안제의 임상적 효과성 비교: 체계적 문헌고찰
Comparative Effectiveness of Sodium Hyaluronate and Carboxymethylcellulose for Dry Eye Syndrome: A Systematic Review
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Objectives: Through a systematic review, we aimed to compare the effectiveness of sodium hyal- uronate (SH) eye-drops and carboxymethylcellulose (CMC) in patients with dry eye syndrome. Methods: A comprehensive search was performed in three foreign databases (MEDLINE, Embase, and CENTRAL) and five Korean databases up to March 2019 for a systematic review. We included studies that reported tear break-up time (TBUT) or Schirmer’s test results from clinical studies that compared SH eye-drops and CMC. A meta-analysis using random-effects model was conducted to consider the heterogeneity among the studies. Results: Nine studies (10 comparisons) across 754 subjects were selected. Among those, eight studies used randomized control trials (RCTs). The re- sults of a meta-analysis on TBUT showed no statistically significant difference between SH eye- drops and CMC [mean difference (MD) -0.47; 95% confidence interval (CI) -1.11, 0.18], and on Schirmer’s test (MD 0.39; 95% CI -0.71, 1.49). No significant differences between the two groups were found on corneal staining score [standardized mean difference (SMD) -0.10; 95% CI -0.31, 0.12], conjunctival staining score (SMD -0.12; 95% CI -0.34, 0.11), and symptom score (SMD -0.00; 95% CI -0.18, 0.17). Conclusion: Compared with SH and CMC eye-drops, result of this meta- analysis provides evidence that both medicines were found to have no significant differences in all major results that measure the effectiveness of clinical treatment in dry eye syndrome.
Abstract
Objectives: Through a systematic review, we aimed to compare the effectiveness of sodium hyal- uronate (SH) eye-drops and carboxymethylcellulose (CMC) in patients with dry eye syndrome. Methods: A comprehensive search was performed in three foreign databases (MEDLINE, Embase, and CENTRAL) and five Korean databases up to March 2019 for a systematic review. We included studies that reported tear break-up time (TBUT) or Schirmer’s test results from clinical studies that compared SH eye-drops and CMC. A meta-analysis using random-effects model was conducted to consider the heterogeneity among the studies. Results: Nine studies (10 comparisons) across 754 subjects were selected. Among those, eight studies used randomized control trials (RCTs). The re- sults of a meta-analysis on TBUT showed no statistically significant difference between SH eye- drops and CMC [mean difference (MD) -0.47; 95% confidence interval (CI) -1.11, 0.18], and on Schirmer’s test (MD 0.39; 95% CI -0.71, 1.49). No significant differences between the two groups were found on corneal staining score [standardized mean difference (SMD) -0.10; 95% CI -0.31, 0.12], conjunctival staining score (SMD -0.12; 95% CI -0.34, 0.11), and symptom score (SMD -0.00; 95% CI -0.18, 0.17). Conclusion: Compared with SH and CMC eye-drops, result of this meta- analysis provides evidence that both medicines were found to have no significant differences in all major results that measure the effectiveness of clinical treatment in dry eye syndrome.
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