항혈소판약물과 생약제의 상호작용: 리뷰
A Review of Herbal Interactions with Antiplatelet Drugs
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Objectives : Antiplatelet agents are commonly used worldwide for the prevention ofcardiovascular or cerebrovascular diseases by inhibiting platelet aggregation and thrombus formation. As the herbal medicine and crude drug market is gradually expanding with increasedpopularity, drug-herb interaction has become a rising topic. The most frequently interactingdrugs with herbs were reported to be antiplatelet agents and anticoagulants. The purpose of thisresearch is to focus on the interactions in antiplatelet agents with herbal medicines in order topresent safe use of these agents, including aspirin or clopidogrel, along with the effective use ofCAM (Complementary and Alternative Medicine). Methods : This research includes literatures on only the clinical results of drug interactions, primarilyassembled from PubMed and additionally from MedlinePlus Drugs and Supplements Directory, Martindale, Natural Standard, BNF, Stockely’s Herbal Medicines, etc. Results : Herbs that resulted in teractions with an antiplatelet agent were as follows : aloe vera,garlic, ginger, ginkgo, ginseng, and St. John’s wort. The results were all clinical and had morethan one case. Studies on garlic, ginger, and ginkgo were conducted on healthy adult subjectswhereas the clinical study on St. John’s wort was conducted on patients with stent placed ontheir coronary artery. Conclusions : Although clinical studies and cases on drug-herb interaction had varied results, theresults could lead to the conclusion that many herbal medicines will have interactions withantiplatelet agents. Therefore, potential interactions should be considered when simultaneouslyusing herbal medicine and conventional medicine prior to treatment. Further research using alarger population is required for more accurate results.
Abstract
Objectives : Antiplatelet agents are commonly used worldwide for the prevention ofcardiovascular or cerebrovascular diseases by inhibiting platelet aggregation and thrombus formation. As the herbal medicine and crude drug market is gradually expanding with increasedpopularity, drug-herb interaction has become a rising topic. The most frequently interactingdrugs with herbs were reported to be antiplatelet agents and anticoagulants. The purpose of thisresearch is to focus on the interactions in antiplatelet agents with herbal medicines in order topresent safe use of these agents, including aspirin or clopidogrel, along with the effective use ofCAM (Complementary and Alternative Medicine). Methods : This research includes literatures on only the clinical results of drug interactions, primarilyassembled from PubMed and additionally from MedlinePlus Drugs and Supplements Directory, Martindale, Natural Standard, BNF, Stockely’s Herbal Medicines, etc. Results : Herbs that resulted in teractions with an antiplatelet agent were as follows : aloe vera,garlic, ginger, ginkgo, ginseng, and St. John’s wort. The results were all clinical and had morethan one case. Studies on garlic, ginger, and ginkgo were conducted on healthy adult subjectswhereas the clinical study on St. John’s wort was conducted on patients with stent placed ontheir coronary artery. Conclusions : Although clinical studies and cases on drug-herb interaction had varied results, theresults could lead to the conclusion that many herbal medicines will have interactions withantiplatelet agents. Therefore, potential interactions should be considered when simultaneouslyusing herbal medicine and conventional medicine prior to treatment. Further research using alarger population is required for more accurate results.
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