외과계 중환자실에서의 약물유해반응 탐색에 대한 방법론적 접근
A Methodological Approach for Detecting Adverse Drug Reactions in the Surgical Intensive Care Unit
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Background : The prevalence of adverse drug reactions (ADRs) in critically ill patients is estimated to be high due to several reasons such as the severity of their underlying diseases, the use of multidrug agents, and the changes in pharmacokinetic parameters. The objectives of this study were to understand the status of ADRs that occurred in the surgical intensive care unit (SICU) and to suggest an optimal monitoring method. Methods : We studied adult patients who were hospitalized in the SICU of the Seoul National University Hospital, a tertiary care hospital in South Korea, between August 3, 2015 and September 11, 2015. ADRs were detected by prospective monitoring, retrospective monitoring, and signal monitoring and assessed by a pharmacist in terms of causality, severity, preventability, seriousness, recovery, and types. The sensitivity of each monitoring method and the positive predictive value (PPV) of the signals were also calculated.
Abstract
Background : The prevalence of adverse drug reactions (ADRs) in critically ill patients is estimated to be high due to several reasons such as the severity of their underlying diseases, the use of multidrug agents, and the changes in pharmacokinetic parameters. The objectives of this study were to understand the status of ADRs that occurred in the surgical intensive care unit (SICU) and to suggest an optimal monitoring method. Methods : We studied adult patients who were hospitalized in the SICU of the Seoul National University Hospital, a tertiary care hospital in South Korea, between August 3, 2015 and September 11, 2015. ADRs were detected by prospective monitoring, retrospective monitoring, and signal monitoring and assessed by a pharmacist in terms of causality, severity, preventability, seriousness, recovery, and types. The sensitivity of each monitoring method and the positive predictive value (PPV) of the signals were also calculated.
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