Bacterial Postbiotics as Promising Tools to Mitigate Cardiometabolic Diseases
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초록
Gut microbes dictate critical features of host immunometabolism. Certain bacterial components and metabolites (termed postbiotics) mitigate cardiometabolic diseases whereas others potentiate pathological processes. In this review, we discuss key aspects related to the usefulness of bacterial-related molecules strategically positioned as promising treatment strategies for cardiometabolic diseases.
Abstract
Gut microbes dictate critical features of host immunometabolism. Certain bacterial components and metabolites (termed postbiotics) mitigate cardiometabolic diseases whereas others potentiate pathological processes. In this review, we discuss key aspects related to the usefulness of bacterial-related molecules strategically positioned as promising treatment strategies for cardiometabolic diseases.
참고문헌 (42)
- Anhê FF, "Bacteria to alleviate metabolic syndrome", Nat Med, 25, pp.1031~1033 (2019)
- Depommier C, "Supplementation with Akkermansia muciniphila in overweight and obese human volunteers : a proof-of-concept exploratory study", Nat Med, 25, pp.1096~1103 (2019)
- "Nat Med", 2017, 107~113
- Everard A, "Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity", Proc Natl Acad Sci U S A, 110, pp.9066~9071 (2013)
- Shen J, "Low-density lipoprotein receptor signaling mediates the triglyceride-lowering action of Akkermansia muciniphila in genetic-induced hyperlipidemia", Arterioscler Thromb Vasc Biol, 36, pp.1448~1456 (2016)
- Li J, "Akkermansia muciniphila protects against atherosclerosis by preventing metabolic endotoxemia-induced inflammation in Apoe-", -mice, 2016, pp.133, 2434~2446
- Sakai T, "Lactobacillus plantarum OLL2712 regulates glucose metabolism in C57BL", 6 mice fed a high-fat diet, 2013, pp.59, 144~147
- Hernández MA, "The short-chain fatty acid acetate in body weight control and insulin sensitivity", Nutrients, 11, pp.1943~ (2019)
- Canfora EE, "Short-chain fatty acids in control of body weight and insulin sensitivity", Nat Rev Endocrinol, 11, pp.577~591 (2015)
- Zheng D, "Interaction between microbiota and immunity in health and disease", Cell Res, 30, pp.492~506 (2020)
- Cani PD, "Metabolic endotoxemia initiates obesity and insulin resistance", Diabetes, 56, pp.1761~1772 (2007)
- Ahmadi SF, "Reverse epidemiology of traditional cardiovascular risk factors in the geriatric population", J Am Med Dir Assoc, 16, pp.933~939 (2015)
- McClelland RL, "10-year coronary heart disease risk prediction using coronary artery calcium and traditional risk factors : derivation in the MESA(Multi-Ethnic Study of Atherosclerosis)with validation in the HNR(Heinz Nixdorf Recall)study and the DHS(Dallas Heart Study)", J Am Coll Cardiol, 66, pp.1643~1653 (2015)
- Greer RL, "Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism", Nat Commun, 7, pp.13329~ (2016)
- Schertzer JD, "NOD1 activators link innate immunity to insulin resistance", Diabetes, 60, pp.2206~2215 (2011)
- Amar J, "Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes : molecular mechanisms and probiotic treatment", EMBO Mol Med, 3, pp.559~572 (2011)
- Hergott CB, "Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis", Blood, 127, pp.2460~2471 (2016)
- Clarke TB, "Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity", Nat Med, 16, pp.228~231 (2010)
- Hedl M, "Chronic stimulation of Nod2 mediates tolerance to bacterial products", Proc Natl Acad Sci U S A, 104, pp.19440~19445 (2007)
- Denou E, "Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance", EMBO Mol Med, 7, pp.259~274 (2015)
- Cavallari JF, "NOD2 in hepatocytes engages a liver-gut axis to protect against steatosis, fibrosis, and gut dysbiosis during fatty liver disease in mice", Am J Physiol Endocrinol Metab, 319, pp.E305~ (2020)
- Grimm MC, "NOD2 mutations and Crohn's disease : are Paneth cells and their antimicrobial peptides the link?", Gut, 53, pp.1558~1560 (2004)
- Jensen BA, "Microbial translocation in type 2 diabetes : when bacterial invaders overcome host defence in human obesity", Gut, 69, pp.1724~1726 (2020)
- Cavallari JF, "Muramyl dipeptide-based postbiotics mitigate obesity-induced insulin resistance via IRF4", Cell Metab, 25, pp.1063~1074 (2017)
- Nishio H, "Nod1 ligands induce site-specific vascular inflammation", Arterioscler Thromb Vasc Biol, 31, pp.1093~1099 (2011)
- Vlacil AK, "Deficiency of Nucleotide-binding oligomerization domain-containing proteins(NOD)1 and 2 reduces atherosclerosis", Basic Res Cardiol, 115, pp.47~ (2020)
- Cavallari JF, "Postbiotics for NOD2 require nonhematopoietic RIPK2 to improve blood glucose and metabolic inflammation in mice", Am J Physiol Endocrinol Metab, 318, pp.E579~ (2020)
- Croyal M, "Plasma trimethylamine N-oxide and risk of cardiovascular events in patients with type 2 diabetes", J Clin Endocrinol Metab (2020)
- Tang WH, "Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk", N Engl J Med, 368, pp.1575~1584 (2013)
- Wang Z, "Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease", Nature, 472, pp.57~63 (2011)
- Koeth RA, "Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis", Nat Med, 19, pp.576~585 (2013)
- Zhu W, "Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk", Cell, 165, pp.111~124 (2016)
- Li Z, "Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis", Lab Invest, 99, pp.346~357 (2019)
- Wang G, "3, 3-Dimethyl-1-butanol attenuates cardiac remodeling in pressure-overload-induced heart failure mice", J Nutr Biochem, 78, pp.108341~ (2020)
- Seldin MM, "Trimethylamine N-oxide promotes vascular inflammation through signaling of mitogen-activated protein kinase and nuclear factor-κB", J Am Heart Assoc, 5, pp.e002767~ (2016)
- Chen ML, "Trimethylamine-N-oxide induces vascular inflammation by activating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway", J Am Heart Assoc, 6, pp.e006347~ (2017)
- Makrecka-Kuka M, "Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria", Toxicol Lett, 267, pp.32~38 (2017)
- Heianza Y, "Long-term changes in gut microbial metabolite trimethylamine N-oxide and coronary heart disease risk", J Am Coll Cardiol, 75, pp.763~772 (2020)
- Chen ML, "Resveratrol attenuates trimethylamine-N-oxide(TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota", MBio, 7, pp.e02210~ (2016)
- Chen S, "Effects of probiotic supplementation on serum trimethylamine-N-oxide level and gut microbiota composition in young males: a double-blinded randomized controlled trial", Eur J Nutr (2020)[DOI]
- Wang Z, "Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis", Cell, 163, pp.1585~1595 (2015)
- Organ CL, "Nonlethal inhibition of gut microbial trimethylamine N-oxide production improves cardiac function and remodeling in a murine model of heart failure", J Am Heart Assoc, 9, pp.e016223~ (2020)
