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담당약사의 처방중재활동에 대한 약물유해반응 예방의 비교 분석

The Comparison Analysis of the Prevention of Adverse Drug Events through Order Interventions by Designated-pharmacists

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Background : It is well known that adverse drug events(ADEs) increase the length ofstay and charges in the hospital setting. Interventions by clinical pharmacists have been shown tobe a first step to prevent these medication errors and are associated with safe and effective pharmacotherapy. As an effort to increase appropriate interventions, Bundang Seoul National UniversityHospital(SNUBH) has designated clinical pharmacists who are in charge of medical intensive careunit(MICU), neonatal intensive care unit(NICU), surgical intensive care unit(SICU), geriatric carecenter(GC). and respiratory care center(RC). Interventions conducted are supposed to be recorded inelectronic medical records(EMR) and can be shared between pharmacists, which maximizes workefficiency. Objective : In order to measure the effect of designated-pharmacists on interventions, interventionsperformed by designated-pharmacists and non designated-pharmacists were analyzed. Methods : A retrospective database review of recorded clinical interventions by pharmacists wasconducted to classify interventions by types and an acceptance. One resident pharmacist(postgraduate year 1 or PGY1) and two clinical pharmacists not involved in the data collection valuateda prevention of ADEs. Cost avoidance was calculated to estimate the seriousness of ADEs andpotential extra cost in the absence of the intervention. Results : Five hundreds ninety interventions were documented during 1-month study period. The intervention rate by designated-pharmacists was 0.44%, which was higher than non designatedpharmacists by 0.32%. An acceptance rate by designated-pharmacists and non designatedpharmacistswas 76.1% and 68.5% respectively. Sixty three interventions were judged to haveprevented potential ADEs, of which thirty seven interventions had been conducted by designated-pharmacists. The estimated cost avoidance from interventions by designated-pharmacistswas approximately 10,030,000won and counts for 77% of total. Conclusions : In respect of the intervention rate, the acceptance rate, the prevention of ADEs,and the cost avoidance, designated-pharmacist policy has positive effect on pharmacotherapy.

Abstract

Background : It is well known that adverse drug events(ADEs) increase the length ofstay and charges in the hospital setting. Interventions by clinical pharmacists have been shown tobe a first step to prevent these medication errors and are associated with safe and effective pharmacotherapy. As an effort to increase appropriate interventions, Bundang Seoul National UniversityHospital(SNUBH) has designated clinical pharmacists who are in charge of medical intensive careunit(MICU), neonatal intensive care unit(NICU), surgical intensive care unit(SICU), geriatric carecenter(GC). and respiratory care center(RC). Interventions conducted are supposed to be recorded inelectronic medical records(EMR) and can be shared between pharmacists, which maximizes workefficiency. Objective : In order to measure the effect of designated-pharmacists on interventions, interventionsperformed by designated-pharmacists and non designated-pharmacists were analyzed. Methods : A retrospective database review of recorded clinical interventions by pharmacists wasconducted to classify interventions by types and an acceptance. One resident pharmacist(postgraduate year 1 or PGY1) and two clinical pharmacists not involved in the data collection valuateda prevention of ADEs. Cost avoidance was calculated to estimate the seriousness of ADEs andpotential extra cost in the absence of the intervention. Results : Five hundreds ninety interventions were documented during 1-month study period. The intervention rate by designated-pharmacists was 0.44%, which was higher than non designatedpharmacists by 0.32%. An acceptance rate by designated-pharmacists and non designatedpharmacistswas 76.1% and 68.5% respectively. Sixty three interventions were judged to haveprevented potential ADEs, of which thirty seven interventions had been conducted by designated-pharmacists. The estimated cost avoidance from interventions by designated-pharmacistswas approximately 10,030,000won and counts for 77% of total. Conclusions : In respect of the intervention rate, the acceptance rate, the prevention of ADEs,and the cost avoidance, designated-pharmacist policy has positive effect on pharmacotherapy.

참고문헌 (8)

  1. Kopp B.J, "Cost implications of and potential adverse events prevented by interventions of a critical care pharmacist", Am J Health Syst Pharm, 64, pp.2483~2487 (2007)
  2. 김형숙, "노인의료센터 입원환자의 약물유해반응 현황 및 위험인자 분석", 병원약사회지, 25(4), pp.1~10 (2008), 한국병원약사회
  3. Michael J. Dooley, "A prospective multicentre study of pharmacist initiated changes to drug therapy and patient management in acute care government funded hospitals", Br J Clin Pharmacol, 57, pp.513~521 (2004)
  4. Lucian L. Leape, "Pharmacist participation on physician rounds and adverse drug events in the intensive care unit", JAMA, 282, pp.267~270 (1999)
  5. Koo H.Y., "Effects of adverse drug reactions detected using monitoring program on the length of stay and charges in the hospital setting. Doctoral dissertation", pp.2009
  6. Todd W. Nesbit, "Implementation and pharmacoeconomic analysis of a clinical staff pharmacist practice model", Am J Health-Syst Pharm, 58, pp.784~790 (2001)
  7. Cavicchi M., "Prevalence of liver disease and contributing factors in patients receiving home parenteral nutrition for permanent intestinal failure", Ann Intern Med, 132(7), pp.525~532 (2000)
  8. David W. Bates, "Incidence of adverse drug events and potential adverse drug events", JAMA, 274, pp.29~34 (1995)

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