The Triglyceride-Glucose Index Can Predict Long-Term Major Adverse Cardiovascular Events in Turkish Patients With High Cardiovascular Risk
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Objective: There is an evidence gap regarding the predictive accuracy of the triglyceride-glucose (TyG) index for long-term major adverse cardiovascular events (MACEs) in individuals with high cardiovascular risk. The aim of this investigation was to evaluate the predictive value of the TyG index for long-term MACEs in patients at high cardiovascular risk. Methods: In total, 483 patients with high cardiovascular risk were included in this analysis. The study population was separated into 2 groups depending on the occurrence of long-term MACEs. The independent predictors of long-term MACEs in patients with high cardiovascular risk were investigated. The long-term prognostic value of the TyG index in these patients was evaluated in terms of MACEs. Results: Age, male sex, diabetes mellitus, and the TyG index were demonstrated to be independent predictors of long-term MACE occurrence in patients with high cardiovascular risk. The TyG index was independently related to long-term MACEs in patients with high cardiovascular risk (hazard ratio, 1.003; 95% confidence interval [CI], 1.001-1.006; p=0.011). The receiver operating characteristic curve revealed that the optimum value of the TyG index to predict long-term MACEs in the overall study cohort was >9.68, with 65% sensitivity and 63% specificity (area under the curve, 0.71; 95% CI, 0.65-0.77; p<0.001). Conclusion: The TyG index was demonstrated to be an independent predictor of long-term MACE occurrence in patients with high cardiovascular risk who had not been previously diagnosed with cardiovascular disease.
Abstract
Objective: There is an evidence gap regarding the predictive accuracy of the triglyceride-glucose (TyG) index for long-term major adverse cardiovascular events (MACEs) in individuals with high cardiovascular risk. The aim of this investigation was to evaluate the predictive value of the TyG index for long-term MACEs in patients at high cardiovascular risk. Methods: In total, 483 patients with high cardiovascular risk were included in this analysis. The study population was separated into 2 groups depending on the occurrence of long-term MACEs. The independent predictors of long-term MACEs in patients with high cardiovascular risk were investigated. The long-term prognostic value of the TyG index in these patients was evaluated in terms of MACEs. Results: Age, male sex, diabetes mellitus, and the TyG index were demonstrated to be independent predictors of long-term MACE occurrence in patients with high cardiovascular risk. The TyG index was independently related to long-term MACEs in patients with high cardiovascular risk (hazard ratio, 1.003; 95% confidence interval [CI], 1.001-1.006; p=0.011). The receiver operating characteristic curve revealed that the optimum value of the TyG index to predict long-term MACEs in the overall study cohort was >9.68, with 65% sensitivity and 63% specificity (area under the curve, 0.71; 95% CI, 0.65-0.77; p<0.001). Conclusion: The TyG index was demonstrated to be an independent predictor of long-term MACE occurrence in patients with high cardiovascular risk who had not been previously diagnosed with cardiovascular disease.
참고문헌 (23)
- Barquera S, "Global overview of the epidemiology of atherosclerotic cardiovascular disease", Arch Med Res, 46, pp.328~338 (2015)
- Arnett DK, "2019 ACC", AHA guideline on the primary prevention of cardiovascular disease : executive summary : a report of the American College of Cardiology, Circulation, pp.2019, 140[DOI]
- Reddy KJ, "The role of insulin resistance in the pathogenesis of atherosclerotic cardiovascular disease: an updated review", J Cardiovasc Med(Hagerstown), 11, pp.633~647 (2010)
- Lim J, "Comparison of triglyceride glucose index, and related parameters to predict insulin resistance in Korean adults : an analysis of the 2007-2010 Korean National Health and Nutrition Examination Survey", PLoS One, 14, pp.e0212963~ (2019)
- Son DH, "Comparison of triglyceride-glucose index and HOMA-IR for predicting prevalence and incidence of metabolic syndrome", Nutr Metab Cardiovasc Dis, 32, pp.596~604 (2022)
- Zhao Y, "Elevated triglyceride-glucose index predicts risk of incident ischaemic stroke : the Rural Chinese Cohort Study", Diabetes Metab, 47, pp.101246~ (2021)
- Zhu Y, "Triglyceride-glucose index is associated with in-stent restenosis in patients with acute coronary syndrome after percutaneous coronary intervention with drug-eluting stents", Cardiovasc Diabetol, 20, pp.137~ (2021)
- Akbar MR, "The association between triglyceride-glucose index and major adverse cardiovascular events in patients with acute coronary syndrome – dose-response meta-analysis", Nutr Metab Cardiovasc Dis, 31, pp.3024~3030 (2021)
- GoffDC Jr, "2013 ACC", AHA guideline on the assessment of cardiovascular risk : a report of the American College of Cardiology, Circulation, pp.2014, 129[DOI]
- Otterstad JE, "Measuring left ventricular volume and ejection fraction with the biplane Simpson’s method", Heart, 88, pp.559~560 (2002)
- De Smedt D, "The gender gap in risk factor control : effects of age and education on the control of cardiovascular risk factors in male and female coronary patients. The EUROASPIRE IV study by the European Society of Cardiology", Int J Cardiol, 209, pp.284~290 (2016)
- Jin JL, "Triglyceride glucose index for predicting cardiovascular outcomes in patients with coronary artery disease", J Thorac Dis, 10, pp.6137~6146 (2018)
- Gao A, "Association between the triglyceride glucose index and coronary collateralization in coronary artery disease patients with chronic total occlusion lesions", Lipids Health Dis, 20, pp.140~ (2021)
- Rewers M, "Insulin sensitivity, insulinemia, and coronary artery disease : the Insulin Resistance Atherosclerosis Study", Diabetes Care, 27, pp.781~787 (2004)
- Guerrero-Romero F, "The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp", J Clin Endocrinol Metab, 95, pp.3347~3351 (2010)
- Tao LC, "Triglyceride-glucose index as a marker in cardiovascular diseases : landscape and limitations", Cardiovasc Diabetol, 21, pp.68~ (2022)
- Nishikawa T, "Impact of mitochondrial ROS production in the pathogenesis of insulin resistance", Diabetes Res Clin Pract, 77(Suppl 1), pp.S161~S164 (2007)
- Cho YR, "Association between insulin resistance, hyperglycemia, and coronary artery disease according to the presence of diabetes", Sci Rep, 9, pp.6129~ (2019)
- Sánchez-Íñigo L, "The TyG index may predict the development of cardiovascular events", Eur J Clin Invest, 46, pp.189~197 (2016)
- Wang L, "Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome", Cardiovasc Diabetol, 19, pp.80~ (2020)
- Lee SB, "Association between triglyceride glucose index and arterial stiffness in Korean adults", Cardiovasc Diabetol, 17, pp.41~ (2018)
- Kim MK, "Relationship between the triglyceride glucose index and coronary artery calcification in Korean adults", Cardiovasc Diabetol, 16, pp.108~ (2017)
- Guo W, "The prognostic value of the triglyceride glucose index in patients with chronic heart failure and type 2 diabetes : a retrospective cohort study", Diabetes Res Clin Pract, 177, pp.108786~ (2021)