Acral-type Malignant Acanthosis Nigricans Associated with Gastric Adenocarcinoma
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Acanthosis nigricans is a symmetric eruption characterized by the presence of a hyperpigmented, velvety cutaneous thickening, that can develop on any part of the body, but characteristically affects the flexural areas of the body. The velvety hyperkeratotic lesions can be located on the dorsum of the hands and feet in dark-skinned people in the form of a variant of acanthosis nigricans called as acral acanthotic anomaly or acral type acanthosis nigricans. Although acanthosis nigricans is associated with malignant tumors, particularly gastric carcinoma, acral type acanthosis nigricans has never been reported to be associated with gastric adenocarcinoma. In our present study, we describe a case of 58-year-old man with acral type acanthosis nigricans and its association with carcinoma of the stomach; a marked improvement was seen in the skin condition of the patient with chemotherapy. (Ann Dermatol 23(S2) S208∼S210, 2011)
Abstract
Acanthosis nigricans is a symmetric eruption characterized by the presence of a hyperpigmented, velvety cutaneous thickening, that can develop on any part of the body, but characteristically affects the flexural areas of the body. The velvety hyperkeratotic lesions can be located on the dorsum of the hands and feet in dark-skinned people in the form of a variant of acanthosis nigricans called as acral acanthotic anomaly or acral type acanthosis nigricans. Although acanthosis nigricans is associated with malignant tumors, particularly gastric carcinoma, acral type acanthosis nigricans has never been reported to be associated with gastric adenocarcinoma. In our present study, we describe a case of 58-year-old man with acral type acanthosis nigricans and its association with carcinoma of the stomach; a marked improvement was seen in the skin condition of the patient with chemotherapy. (Ann Dermatol 23(S2) S208∼S210, 2011)
참고문헌 (7)
- Christine AD, "Cutaneous manifestation of internal malignant disease. In Fitzpatrick's dermatology in general medicine. 7th ed", pp.1494~1498 (2008), New York: McGraw-Hill
- Curth HO, "Classification of acanthosis nigricans", Int J Dermatol, 15, pp.592~593 (1976)
- Schwartz RA, "Acral acanthotic anomaly (AAA)", J Am Acad Dermatol, 5, pp.345~346 (1981)
- Melczer N, "Acanthosisnigricans bei dermatofibroma protuberans mit multiplen hautmetastasen", Hautarzt, 8, pp.54~58 (1957)
- 송지연, "림프종 환자에서 발생한 선단형 흑색 극세포증 1예", 대한피부과학회지, 40(7), pp.841~843 (2002), 대한피부과학회
- Koyama S, "Transforming growth factor-alpha (TGF-α)-producing gastric carcinoma with acanthosis nigricans: an endocrine effect of TGF-α in the pathogenesis of cutaneous paraneoplastic syndrome and epithelial hyperplasia of the esophagus", J Gastroenterol, 32, pp.71~77 (1997)
- Ellis DL, "Melanoma, growth factors, acanthosis nigricans, the sign of Leser-Trelat and multiple acrochordons", N Engl J Med, 317, pp.1582~1587 (1987)