The Short Stature in Atopic Dermatitis Patients: Are Atopic Children Really Small for Their Age?
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background: Short stature is sometimes seen in children with atopic dermatitis (AD); however, the topic has never been studied systematically. Objective: The aim of this study was to show whether AD itself affects stature in children and to evaluate the influence of other relevant factors such as genetic background, diet restrictions, and sleep disturbance on the stature of children with AD. Methods: The study population included Korean children 7 to 8 years of age who live in one district of Seoul, Korea. We used a questionnaire as an investigating tool to survey genetic backgrounds, environmental factors, and comorbidities. Student's t-test and linear regression were employed for statistical analysis. Results: In univariate analysis, the average stature in the AD group was short compared with the normal control group. Parental stature, dietary habit, and sleep patterns were also relevant factors with respect to stature. However, in multivariate analysis, AD itself had no influence on stature. Significant correlations were found for such factors as parental height, sleep disturbance, presence of asthma, and dietary restrictions, in decreasing magnitude. Conclusion: These results suggest that AD itself may not be the causative factor for short stature in children with AD. Therefore, consideration of other relevant factors related to short stature in patients with AD will be important for the proper management of the disease.
Abstract
Background: Short stature is sometimes seen in children with atopic dermatitis (AD); however, the topic has never been studied systematically. Objective: The aim of this study was to show whether AD itself affects stature in children and to evaluate the influence of other relevant factors such as genetic background, diet restrictions, and sleep disturbance on the stature of children with AD. Methods: The study population included Korean children 7 to 8 years of age who live in one district of Seoul, Korea. We used a questionnaire as an investigating tool to survey genetic backgrounds, environmental factors, and comorbidities. Student's t-test and linear regression were employed for statistical analysis. Results: In univariate analysis, the average stature in the AD group was short compared with the normal control group. Parental stature, dietary habit, and sleep patterns were also relevant factors with respect to stature. However, in multivariate analysis, AD itself had no influence on stature. Significant correlations were found for such factors as parental height, sleep disturbance, presence of asthma, and dietary restrictions, in decreasing magnitude. Conclusion: These results suggest that AD itself may not be the causative factor for short stature in children with AD. Therefore, consideration of other relevant factors related to short stature in patients with AD will be important for the proper management of the disease.
참고문헌 (21)
- Kay J, "The prevalence of childhood atopic eczema in a general population", J Am Acad Dermatol, 30, pp.35~39 (1994)
- Rajka G, "Natural history and clinical manifestations of atopic dermatitis", Clin Rev Allergy, 4, pp.3~26 (1986)
- Pike MG, "Growth in atopic eczema: a controlled study by questionnaire", Arch Dis Child, 64, pp.1566~1569 (1989)
- Patel L, "Adult height in patients with childhood onset atopic dermatitis", Arch Dis Child, 76, pp.505~508 (1997)
- Ferguson AC, "Short stature and delayed skeletal maturation in children with allergic disease", J Allergy Clin Immunol, 69, pp.461~466 (1982)
- Cohen MB, "Growth patterns of allergic children; a statistical study using the grid technique", J Allergy, 19, pp.165~171 (1948)
- Ukabam SO, "Small intestinal permeability to sugars in patients with atopic eczema", Br J Dermatol, 110, pp.649~652 (1984)
- Sloper KS, "Eczema and atopy in early childhood: low IgA plasma cell counts in the jejunal mucosa", Arch Dis Child, 56, pp.939~942 (1981)
- Tarnow-Mordi WO, "Failure to thrive owing to inappropriate diet free of gluten and cows' milk", Br Med J (Clin Res Ed), 289, pp.1113~1114 (1984)
- Tanner JM, "Standards for children's height at ages 2-9 years allowing for heights of parents", Arch Dis Child, 45, pp.755~762 (1970)
- 박영립, "아토피피부염 학회보고서: 한국인 아토피피부염의 진단기준에 대한 연구", 대한피부과학회지, 44(6), pp.659~663 (2006), 대한피부과학회
- Leung DYM, "Atopic dermatitis, In Dermatology in general medicine. 4th ed", pp.1543~1564 (1993), McGraw-Hill Book
- Ashtoon R, "Differential diagnosis in dermatology. 2nd ed", pp.103~105 (1992), Radcliffe medical press
- Kristmundsdottir F, "Growth impairment in children with atopic eczema", J R Soc Med, 80, pp.9~12 (1987)
- Thomas MW, "Corticosteroids' effect on the height of atopic dermatitis patients: a controlled questionnaire study", Pediatr Dermatol, 26, pp.524~528 (2009)
- Murray AB, "Chronic asthma and growth failure in children", Lancet, 2, pp.197~198 (1976)
- Patel L, "Adrenal function following topical steroid treatment in children with atopic dermatitis", Br J Dermatol, 132, pp.950~955 (1995)
- Vermeer BJ, "A case of growth retardation and cushing's syndrome due to excessive application of betamethasone- 17-valerate ointment", Dermatologica, 149, pp.299~304 (1974)
- Allen DB, "Effects of inhaled steroids on growth, bone metabolism, and adrenal function", Adv Pediatr, 53, pp.101~110 (2006)
- Campbell TA, "Incidence of sleep disorders in children with presumed normal variant short stature", J Paediatr Child Health, 41, pp.358~360 (2005)
- Charman C, "The use of corticosteroids and corticosteroid phobia in atopic dermatitis", Clin Dermatol, 21, pp.193~200 (2003)