Retrospective Clinical Trial of Fusidic Acid versus Petrolatum in the Postprocedure Care of Clean Dermatologic Procedures
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Background: Clean dermatologic procedures create woundswith a low risk of infection (usually up to 5%). Whether theuse of topical antibiotics is advocated, with regard to itsefficacy and safety issues such as antibiotic resistance andsensitizing potential, is controversial. Fusidic acid, a topicalantibiotic against gram-positive bacteria, is a rare sensitizerand commonly used in postprocedure care in Korea. Objective: This is a retrospective study aimed at comparingthe efficacy and safety between fusidic acid and petrolatumfor the postprocedure care of clean dermatologic procedures. Methods: Patients were treated with either fusidic acid orpetrolatum ointment, applied on the wound created duringclean dermatologic procedures such as biopsy of the punch,incisional, excisional, and shave types. The efficacy, adverseevents, and subjective level of satisfaction were retrievedfrom medical records. Results: A total of 414 patients with atotal of 429 wounds were enrolled. The overall rate of adverseevents was 0.9%, and the rates of adverse events in the fusidicacid group and the petrolatum group were 1.4% and 0.5%,respectively (p=0.370). There was no wound discharge,pain, tenderness, swelling, induration, or dehiscence in bothgroups. The patients’ self-assessment of the wound was notsignificantly different between the two treatment groups. Conclusion: Our findings support the hypothesis that theroutine prophylactic use of topical antibiotics is not indicatedfor clean dermatologic procedures. We recommend the useof petrolatum in the postoperative care of clean dermatologicprocedures because of its equivalent efficacy and superiorsafety profiles.
Abstract
Background: Clean dermatologic procedures create woundswith a low risk of infection (usually up to 5%). Whether theuse of topical antibiotics is advocated, with regard to itsefficacy and safety issues such as antibiotic resistance andsensitizing potential, is controversial. Fusidic acid, a topicalantibiotic against gram-positive bacteria, is a rare sensitizerand commonly used in postprocedure care in Korea. Objective: This is a retrospective study aimed at comparingthe efficacy and safety between fusidic acid and petrolatumfor the postprocedure care of clean dermatologic procedures. Methods: Patients were treated with either fusidic acid orpetrolatum ointment, applied on the wound created duringclean dermatologic procedures such as biopsy of the punch,incisional, excisional, and shave types. The efficacy, adverseevents, and subjective level of satisfaction were retrievedfrom medical records. Results: A total of 414 patients with atotal of 429 wounds were enrolled. The overall rate of adverseevents was 0.9%, and the rates of adverse events in the fusidicacid group and the petrolatum group were 1.4% and 0.5%,respectively (p=0.370). There was no wound discharge,pain, tenderness, swelling, induration, or dehiscence in bothgroups. The patients’ self-assessment of the wound was notsignificantly different between the two treatment groups. Conclusion: Our findings support the hypothesis that theroutine prophylactic use of topical antibiotics is not indicatedfor clean dermatologic procedures. We recommend the useof petrolatum in the postoperative care of clean dermatologicprocedures because of its equivalent efficacy and superiorsafety profiles.
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