Change in Antimicrobial Susceptibility of Skin-Colonizing Staphylococcus aureus in Korean Patients with Atopic Dermatitis during Ten-Year Period
1
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Background: A small subset of adolescents atopic dermatitis (AD) tends to persist. This also leads to get more antibiotics exposure with advancing years. Antibiotic resistance has been regarded as a serious problem during Staphylococcus aureus treatment, especially methicillin-resistant S. aureus (MRSA). Objective: It was investigated the S. aureus colonization frequency in the skin lesions and anterior nares of adolescent AD patients and evaluated the changes in S. aureus antimicrobial susceptibility for years. Methods: Patients who visited our clinic from September 2003 to August 2005 were classified into group A, and patients who visited from August 2010 to March 2012 were classified into group B. To investigate the differences with regard to patients’ age and disease duration, the patients were subdivided into groups according to age. Lesional and nasal specimens were examined. Results: Among the 295 AD patients, the total S. aureus colonization rate in skin lesions was 66.9% (95/142) for group A and 78.4% (120/153) for group B. No significant changes in the systemic antimicrobial susceptibilities of S. aureus strains isolated from adolescent AD patients were observed during about 10-year period. The increased trend of MRSA isolation in recent adolescent AD outpatients suggest that the community including school could be the source of S. aureus antibiotic resistance and higher fusidic acid resistance rates provides evidence of imprudent topical use. Conclusion: Relatively high MRSA isolation and fusidic acid resistance rates in recent AD patients suggest that the community harbors antibiotic-resistant S. aureus.
Abstract
Background: A small subset of adolescents atopic dermatitis (AD) tends to persist. This also leads to get more antibiotics exposure with advancing years. Antibiotic resistance has been regarded as a serious problem during Staphylococcus aureus treatment, especially methicillin-resistant S. aureus (MRSA). Objective: It was investigated the S. aureus colonization frequency in the skin lesions and anterior nares of adolescent AD patients and evaluated the changes in S. aureus antimicrobial susceptibility for years. Methods: Patients who visited our clinic from September 2003 to August 2005 were classified into group A, and patients who visited from August 2010 to March 2012 were classified into group B. To investigate the differences with regard to patients’ age and disease duration, the patients were subdivided into groups according to age. Lesional and nasal specimens were examined. Results: Among the 295 AD patients, the total S. aureus colonization rate in skin lesions was 66.9% (95/142) for group A and 78.4% (120/153) for group B. No significant changes in the systemic antimicrobial susceptibilities of S. aureus strains isolated from adolescent AD patients were observed during about 10-year period. The increased trend of MRSA isolation in recent adolescent AD outpatients suggest that the community including school could be the source of S. aureus antibiotic resistance and higher fusidic acid resistance rates provides evidence of imprudent topical use. Conclusion: Relatively high MRSA isolation and fusidic acid resistance rates in recent AD patients suggest that the community harbors antibiotic-resistant S. aureus.
참고문헌 (42)
- Al. R., "Microbial flora of atopic dermatitis", Arch Dermatol, 113, pp.780~782 (1977)
- David TJ., "Bacterial infection and atopic eczema", Arch Dis Child, 61, pp.20~23 (1986)
- Roll A., "Microbial colonization and atopic dermatitis", Curr Opin Allergy Clin Immunol, 4, pp.373~378 (2004)
- Kim BS., "Colonizing features of Staphylococcus aureus in early childhood atopic dermatitis and in mothers : a cross-sectional comparative study done at four kindergartens in Daegu, South Korea", Ann Allergy Asthma Immunol, 106, pp.323~329 (2011)
- Williams JV., "Saureus isolation from the lesions, the hands, and the anterior nares of patients with atopic dermatitis", Pediatr Dermatol, 15, pp.194~198 (1998)
- Kim BS., "Clarifying the transmission route of Staphylococcus aureus colonizing the skin in early childhood atopic dermatitis", Ann Allergy Asthma Immunol, 109, pp.448~453 (2012)
- Herz U., "Role of T cells in atopic dermatitis. New aspects on the dynamics of cytokine production and the contribution of bacterial superantigens", Int Arch Allergy Immunol, 115, pp.179~190 (1998)
- Lever R., "Staphylococcal colonization in atopic dermatitis and the effect of topical mupirocin therapy", Br J Dermatol, 119, pp.189~198 (1988)
- Chung HJ., "Epidemiological characteristics of methicillin-resistant Staphylococcus aureus isolates from children with eczematous atopic dermatitis lesions", J Clin Microbiol, 46, pp.991~995 (2008)
- Huang JT., "Treatment of Staphylococcus aureus colonization in atopic dermatitis decreases disease severity", Pediatrics, 123, pp.e808~e814 (2009)
- Hanifin JM., "Diagnostic features of atopic dermatitis", Acta Derm Venereol Suppl(Stockh), 92, pp.44~47 (1980)
- Kunz B., "Clinical validation and guidelines for the SCORAD index : consensus report of the European Task Force on Atopic Dermatitis", Dermatology, 195, pp.10~19 (1997)
- Taskapan MO., "Role of staphylococcal superantigens in atopic dermatitis: from colonization to inflammation", Ann Allergy Asthma Immunol, 84, pp.3~10 (2000)
- 성현철, "사춘기 및 성인 아토피피부염 환자에서 스탬프형 배지를 이용한 황색 포도알균의 정량적인 배양", 대한피부과학회지, 45(7), pp.673~679 (2007), 대한피부과학회
- Donal. YML, "Fitzpatrick’s dermatology in general medicine", pp.168~ (2012), McGraw-Hill Medical
- Goh CL., "Skin colonization of Staphylococcus aureus in atopic dermatitis patients seen at the National Skin Centre, Singapore", Int J Dermatol, 36, pp.653~657 (1997)
- Ellis MW, "Treatment approaches for community-acquired methicillin-resistant Staphylococcus aureus infections", Curr Opin Infect Dis, 18, pp.496~501 (2005)
- Diamantis ML., "Update on the characterization of Staphylococcus aureus skin infections in a pediatric dermatology tertiary health care outpatient facility : antibiotic susceptibility patterns and decreased methicillin resistance", J Am Acad Dermatol, 64, pp.440~441 (2011)
- Ortega-Loayza AG., "Characterization of Staphylococcus aureus cutaneous infections in a pediatric dermatology tertiary health care outpatient facility", J Am Acad Dermatol, 62, pp.804~811 (2010)
- Eriksen KR, ""Celbenin"-resistant staphylococci", Ugeskr Laeger, 123, pp.384~386 (1961)
- Fridkin SK., "Active Bacterial Core Surveillance Program of the Emerging Infections Program Network. Methicillin-resistant Staphylococcus aureus disease in three communities", N Engl J Med, 352, pp.1436~1444 (2005)
- Matiz C., "Children with atopic dermatitis appear less likely to be infected with community acquired methicillin-resistant Staphylococcus aureus : the San Diego experience", Pediatr Dermatol, 28, pp.6~11 (2011)
- Fritz SA., "Prevalence of and risk factors for community-acquired methicillin-resistant and methicillin-sensitive staphylococcus aureus colonization in children seen in a practice-based research network", Pediatrics, 121, pp.1090~1098 (2008)
- Hsueh PR, "Decreasing rates of resistance to penicillin, but not erythromycin, in Streptococcus pneumoniae after introduction of a policy to restrict antibiotic usage in Taiwan", Clin Microbiol Infect, 11, pp.925~927 (2005)
- Mitra A., "High levels of fusidic acid-resistant Staphylococcus aureus despite restrictions on antibiotic use", Clin Exp Dermatol, 34, pp.136~139 (2009)
- Shah M., "High levels of fusidic acid-resistant Staphylococcus aureus in dermatology patients", Br J Dermatol, 148, pp.1018~1020 (2003)
- Kedzierska A., "Susceptibility testing and resistance phenotype detection in Staphylococcus aureus strains isolated from patients with atopic dermatitis, with apparent and recurrent skin colonization", Br J Dermatol, 159, pp.1290~1299 (2008)
- Jones JC., "Mupirocin resistance in patients colonized with methicillin-resistant Staphylococcus aureus in a surgical intensive care unit", Clin Infect Dis, 45, pp.541~547 (2007)
- 박세영, "The Prevalence, Genotype and Antimicrobial Susceptibility of High- and Low-Level Mupirocin Resistant Methicillin-Resistant Staphylococcus aureus", Annals of Dermatology, 24(1), pp.32~38 (2012), 대한피부과학회
- Niebuhr M., "Antibiotic treatment of cutaneous infections with Staphylococcus aureus in patients with atopic dermatitis : current antimicrobial resistances and susceptibilities", Exp Dermatol, 17, pp.953~957 (2008)
- Park CW, "Pharmacologic treatment of atopic dermatitis", J Korean Med Assoc, 49, pp.1046~1053 (2006)
- Sugeng MW., "Characteristics of bacterial skin infections in children compared to adults at a tertiary dermatologic center", Int J Dermatol, 38, pp.582~586 (1999)
- Jones ME., "Frequency of occurrence and antimicrobial susceptibility of bacterial pathogens associated with skin and soft tissue infections during 1997 from an International Surveillance Programme. SENTRY Participants Group", Eur J Clin Microbiol Infect Dis, 18, pp.403~408 (1999)
- Doern GV., "Bacterial pathogens isolated from patients with skin and soft tissue infections: frequency of occurrence and antimicrobial susceptibility patterns from the SENTRY Antimicrobial Surveillance Program (United States and Canada, 1997). SENTRY Study Group (North America)", Diagn Microbiol Infect Dis, 34, pp.65~72 (1999)
- Hoeger PH., "Antimicrobial susceptibility of skin-colonizing S. aureus strains in children with atopic dermatitis", Pediatr Allergy Immunol, 15, pp.474~477 (2004)
- Schöfer H., "Staphylococcal infections of the skin and mucous membranes. Guideline of the German Dermatologic Society, Study Group of Dermatologic Infectiology", J Dtsch Dermatol Ges, 3, pp.726~734 (2005)
- 배은영, "농가진의 원인 균주와 항생제 감수성에 관한 연구", 대한피부과학회지, 41(10), pp.1278~1285 (2003), 대한피부과학회
- Hong HJ., "A clinical study on staphylococcus aureus bacteremia", Korean J Med, 53, pp.359~370 (1997)
- Arkwright PD., "Age-related prevalence and antibiotic resistance of pathogenic staphylococci and streptococci in children with infected atopic dermatitis at a single-specialty center", Arch Dermatol, 138, pp.939~941 (2002)
- Ewing CI., "Flucloxacillin in the treatment of atopic dermatitis", Br J Dermatol, 138, pp.1022~1029 (1998)
- Benenson S., "Atopic dermatitis--a risk factor for invasive Staphylococcus aureus infections : two cases and review", Am J Med, 118, pp.1048~1051 (2005)
- Lin YT., "Role of bacterial pathogens in atopic dermatitis", Clin Rev Allergy Immunol, 33, pp.167~177 (2007)
