Vitamin D Status and Its Association with the SCORAD Score and Serum LL-37 Level in Korean Adults and Children with Atopic Dermatitis
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Background: Vitamin D insufficiency could be associatedwith the prevalence of atopic dermatitis (AD). Objective: Toexamine vitamin D status and the relations between serum25-hydroxyvitamin D levels, SCORAD score, serum LL-37level, and body mass index (BMI) in Korean AD patients, andto explore whether these associations differ between adultsand children. Methods: Serum 25-hydroxyvitamin D levels,serum LL-37, and clinical features were analyzed in a total of72 Korean patients with AD (39 adults and 33 children) and140 healthy control subjects (70 adults and 70 children). Results: Serum 25-hydroxyvitamin D levels were significantlyreduced in children with AD (15.06±4.64 ng/ml)compared with normal children in the control group(16.25±6.60 ng/ml) (p=0.036). Significant inverse correlationswere found between BMI and 25-hydroxyvitamin Dlevel (r=−0.315, p=0.007) and between the SCORADscore and serum LL-37 level (r=−0.3, p=0.011) in the totalAD patients. Conclusion: The results showed that serumvitamin D levels were lower in children with AD than inhealthy children; however, the same relation was notobserved between adults with AD and healthy adults. Serum25-hydroxyvitamin D concentration was not significantlycorrelated with AD severity or serum LL-37 levels in ourstudy population.
Abstract
Background: Vitamin D insufficiency could be associatedwith the prevalence of atopic dermatitis (AD). Objective: Toexamine vitamin D status and the relations between serum25-hydroxyvitamin D levels, SCORAD score, serum LL-37level, and body mass index (BMI) in Korean AD patients, andto explore whether these associations differ between adultsand children. Methods: Serum 25-hydroxyvitamin D levels,serum LL-37, and clinical features were analyzed in a total of72 Korean patients with AD (39 adults and 33 children) and140 healthy control subjects (70 adults and 70 children). Results: Serum 25-hydroxyvitamin D levels were significantlyreduced in children with AD (15.06±4.64 ng/ml)compared with normal children in the control group(16.25±6.60 ng/ml) (p=0.036). Significant inverse correlationswere found between BMI and 25-hydroxyvitamin Dlevel (r=−0.315, p=0.007) and between the SCORADscore and serum LL-37 level (r=−0.3, p=0.011) in the totalAD patients. Conclusion: The results showed that serumvitamin D levels were lower in children with AD than inhealthy children; however, the same relation was notobserved between adults with AD and healthy adults. Serum25-hydroxyvitamin D concentration was not significantlycorrelated with AD severity or serum LL-37 levels in ourstudy population.
참고문헌 (30)
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