Four Years Prospective Study of Natural History of Atopic Dermatitis Aged 7∼8 Years at an Individual Level: A Community-Based Survey by Dermatologists’ Skin Examination in Childhood
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Background: The age-dependent change in atopic dermatitis (AD) at an individual level has mostly performed in a hospital- setting. Objective: We evaluated the age-dependent change of AD symptoms at an individual level in a community- setting. Methods: For the diagnostic accuracy, all participants of schoolchildren were received skin examination by dermatologists (twice a year for the same group), instead of questionnaire-based surveys. For this study, sequential check-ups of 273 elementary school children, aged 7∼8 years, were performed for 4 years up to the age of 10∼11 years. Results: Among the 47 AD children, who had been diagnosed as having AD at the first-year check-up, spontaneous remission was detected in nine children during the follow- up periods (remission rate of 19.1%). As a consequence, the one-year AD prevalence was decreased by 5.9% in the elementary schoolchildren over four years. Unexpectedly, late onset (after 8 years of age) AD was observed in 21.7% of AD children. There was no statistically significant relationship between spontaneous remission and host factors including sex and family history of atopic diseases. Conclusion: We observed that 19.1% of AD children in the age group of 7∼ 11 years showed spontaneous remission based on skin examination by dermatologists. There might be an increase in the prevalence of late onset AD in Korea.
Abstract
Background: The age-dependent change in atopic dermatitis (AD) at an individual level has mostly performed in a hospital- setting. Objective: We evaluated the age-dependent change of AD symptoms at an individual level in a community- setting. Methods: For the diagnostic accuracy, all participants of schoolchildren were received skin examination by dermatologists (twice a year for the same group), instead of questionnaire-based surveys. For this study, sequential check-ups of 273 elementary school children, aged 7∼8 years, were performed for 4 years up to the age of 10∼11 years. Results: Among the 47 AD children, who had been diagnosed as having AD at the first-year check-up, spontaneous remission was detected in nine children during the follow- up periods (remission rate of 19.1%). As a consequence, the one-year AD prevalence was decreased by 5.9% in the elementary schoolchildren over four years. Unexpectedly, late onset (after 8 years of age) AD was observed in 21.7% of AD children. There was no statistically significant relationship between spontaneous remission and host factors including sex and family history of atopic diseases. Conclusion: We observed that 19.1% of AD children in the age group of 7∼ 11 years showed spontaneous remission based on skin examination by dermatologists. There might be an increase in the prevalence of late onset AD in Korea.
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