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논문

한국 소아 아토피피부염의 연구 현황과 과제

Current research status of pediatric atopic dermatitis in Korea

편복양
pp. 40-43|DOI https://doi.org/10.4168/aard.2018.6.S1.S40

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Atopic dermatitisResearchPediatric
주제분류소아과학

초록

Atopic dermatitis (AD) is a common allergic inflammatory skin disorder that occurs primarily in children, with a prevalence of 10% to 20% of children worldwide. Genetic factors, environmental factors, immune dysfunction and skin barrier dysfunction play a role in its development. Because there are no definitive laboratory tests, the diagnosis of AD is made based on a combination of clinical symptoms. Since ‘The Study Group for Atopic Dermatitis’ in Korean Academy of Pediatric Allergy and Respiratory Diseases was established in 2003, references regarding research and clinical trials for AD have been increasing. However, those studies were mostly limited to pathogenesis, etiology and clinical symptoms. Education of patients and family members regarding the pathogenesis, treatment goal, prognosis of the disease plays an extremely important role in managing and improving the quality of life of AD. For the personalized, optimizing and communicating management plans, more studies focused on the phenotype of AD and new therapeutic strategies are required.

Abstract

Atopic dermatitis (AD) is a common allergic inflammatory skin disorder that occurs primarily in children, with a prevalence of 10% to 20% of children worldwide. Genetic factors, environmental factors, immune dysfunction and skin barrier dysfunction play a role in its development. Because there are no definitive laboratory tests, the diagnosis of AD is made based on a combination of clinical symptoms. Since ‘The Study Group for Atopic Dermatitis’ in Korean Academy of Pediatric Allergy and Respiratory Diseases was established in 2003, references regarding research and clinical trials for AD have been increasing. However, those studies were mostly limited to pathogenesis, etiology and clinical symptoms. Education of patients and family members regarding the pathogenesis, treatment goal, prognosis of the disease plays an extremely important role in managing and improving the quality of life of AD. For the personalized, optimizing and communicating management plans, more studies focused on the phenotype of AD and new therapeutic strategies are required.

참고문헌 (30)

  1. Schneider L, "Atopic dermatitis: a practice parameter update 2012", J Allergy Clin Immunol, 131, pp.295~299 (2013)[DOI]
  2. Park YM, "Risk factors of atopic dermatitis in Korean schoolchildren: 2010 international study of asthma and allergies in childhood", Asian Pac J Allergy Immunol, 34, pp.65~72 (2016)
  3. Eichenfield LF, "Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis", J Am Acad Dermatol, 70, pp.338~351 (2014)[DOI]
  4. Ricci G, "Long-term follow-up of atopic dermatitis: retrospective analysis of related risk factors and association with concomitant allergic diseases", J Am Acad Dermatol, 55, pp.765~771 (2006)[DOI]
  5. Lee SI, "Prevalences of symptoms of asthma and other allergic diseases in korean children: a nationwide questionnaire survey", J Korean Med Sci, 16, pp.155~164 (2001)[DOI]
  6. 오재원, "Epidemiological Change of Atopic Dermatitis and Food Allergy in School-Aged Children in Korea between 1995 and 2000", Journal of Korean Medical Science, 19(5), pp.716~723 (2004), 대한의학회
  7. 유정석, "Prevalence of Atopic Dermatitis in Korea: Analysis by Using National Statistics", Journal of Korean Medical Science, 27(6), pp.681~685 (2012), 대한의학회[DOI]
  8. 안강모, "Prevalence of Atopic Dermatitis in Korean Children", Allergy, Asthma & Immunology Research, 8(1), pp.1~2 (2016), 대한천식알레르기학회
  9. 이지현, "Prevalence of Atopic Dermatitis in Korean Children Based on Data From the 2008-2011 Korean National Health and Nutrition Examination Survey", Allergy, Asthma & Immunology Research, 8(1), pp.79~83 (2016), 대한천식알레르기학회
  10. 유호성, "Mutations in the Filaggrin are Predisposing Factor in Korean Children With Atopic Dermatitis", Allergy, Asthma & Immunology Research, 5(4), pp.211~215 (2013), 대한천식알레르기학회
  11. 송아리, "단일 기관에서 경험한 소아 아토피피부염 환자의 감작 분포", Allergy Asthma & Respiratory Disease, 4(4), pp.290~295 (2016), 대한 소아알레르기 호흡기학회[DOI]
  12. 정경용, "House Dust Mite Allergy in Korea: The Most Important Inhalant Allergen in Current and Future", Allergy, Asthma & Immunology Research, 4(6), pp.313~325 (2012), 대한천식알레르기학회
  13. 김지현, "The Indoor Level of House Dust Mite Allergen Is Associated with Severity of Atopic Dermatitis in Children", Journal of Korean Medical Science, 28(1), pp.74~79 (2013), 대한의학회
  14. 나민선, "영아 아토피피부염에서 알레르기 감작과 IgE 매개 여부에따른 임상 양상", Allergy Asthma & Respiratory Disease, 5(3), pp.128~134 (2017), 대한 소아알레르기 호흡기학회[DOI]
  15. Hanifin JM. Rajka G, "Diagnostic features of atopic dermatitis", Acta Derm Venereol (Stockh), 92(Suppl), pp.44~47 (1980)
  16. 조지은, "소아 아토피피부염 환자의 부증상 빈도 및 특징에 대한 연구", Clinical and Experimental Pediatrics, 52(7), pp.818~823 (2009), 대한소아청소년과학회
  17. Noda S, "The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization", J Allergy Clin Immunol, 136, pp.1254~1264 (2015)[DOI]
  18. Lee E, "Atopic dermatitis phenotype with early onset and high serum IL-13 is linked to the new development of bronchial hyperresponsiveness in school children", Allergy, 71, pp.692~700 (2016)[DOI]
  19. Kusunoki T, "Month of birth and prevalence of atopic dermatitis in schoolchildren: dry skin in early infancy as a possible etiologic factor", J Allergy Clin Immunol, 103, pp.1148~1152 (1999)[DOI]
  20. Weiland SK, "Climate and the prevalence of symptoms of asthma, allergic rhinitis, and atopic eczema in children", Occup Environ Med, 61, pp.609~615 (2004)[DOI]
  21. Byremo G, "Effect of climatic change in children with atopic eczema", Allergy, 61, pp.1403~1410 (2006)[DOI]
  22. 양윤석, "아토피피부염 환아에서 interleukin-31 및 25-hydroxyvitamin D의 혈청 수치와 아토피피부염의 중증도와의 상관관계", Allergy Asthma & Respiratory Disease, 3(6), pp.396~401 (2015), 대한 소아알레르기 호흡기학회[DOI]
  23. 신영혜, "비타민 D 농도와 아토피피부염 환아의 중증도와의 상관관계", Allergy Asthma & Respiratory Disease, 2(2), pp.114~121 (2014), 대한 소아알레르기 호흡기학회
  24. 백종욱, "2세 이하 아토피피부염 환아에서 비타민 D 부족과 식품항원 감작의 연관성", Allergy Asthma & Respiratory Disease, 1(3), pp.211~215 (2013), 대한 소아알레르기 호흡기학회
  25. 민택기, "아토피피부염 환자에서 혈청 비타민 D 농도와 메티실린 저항성 황색포도구균 피부 집락화의 연관성", Allergy Asthma & Respiratory Disease, 1(2), pp.138~143 (2013), 대한 소아알레르기 호흡기학회
  26. 김민혜, "A Metagenomic Analysis Provides a Culture-Independent Pathogen Detection for Atopic Dermatitis", Allergy, Asthma & Immunology Research, 9(5), pp.453~461 (2017), 대한천식알레르기학회
  27. Hong SW, "An important role of <TEX>$\alpha$<", TEX>-hemolysin in extracellular vesicles on the development of atopic dermatitis induced by Staphylococcus aureus, 2014, pp.9, e100499~
  28. Hong SW, "Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation", Allergy, 66, pp.351~359 (2011)[DOI]
  29. 김정은, "Consensus Guidelines for the Treatment of Atopic Dermatitis in Korea (Part I): General Management and Topical Treatment", Annals of Dermatology, 27(5), pp.563~577 (2015), 대한피부과학회
  30. 김정은, "Consensus Guidelines for the Treatment of Atopic Dermatitis in Korea (Part II): Systemic Treatment", Annals of Dermatology, 27(5), pp.578~592 (2015), 대한피부과학회

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