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전조성 편두통과 호모시스테인 및 MTHFR C677T 유전자 다형성의 상관 관계

Association between Migraine with Aura and both Homocysteine and MTHFR C677T Polymorphism

김현조|이일형|김옥준|최병옥|서정호
대한신경과학회 (Korean Neurological Association)|2004.06|대한신경과학회지 (Journal of the Korean Neurological Association)|제22권 제3호|pp. 200-205

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참고문헌

주제분류신경과학

초록

Abstract

Background: The pathophysiology of migraine is not yet fully understood. Homocysteine acts as an excitatory amino acid in vivo and may influence the threshold of migraine. The previous studies have revealed strong association between the homozygous C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene and hyperhomocysteinemia. In this study, we examined the association between both homocysteine and MTHFR C677T polymorphism and headache, such as migraine and tension headache. Methods: We enrolled 148 headache patients (75 tension headache, 34 migraine with aura [MWA], and 39 migraine without aura [MOA]) and 121 normal controls; checked their fasting homocysteine levels and analyzed for the MTHFR C677T polymorphism. For the multivariate analysis, we used logistic regression to adjust for age and sex. Results: Plasma homocysteine levels were significantly higher in patients with MWA than those in controls (adjusted odds ratio (AOR), 1.12; 95% confidence intervals (CI), 1.02~1.23). The AOR and 95% CI of the MTHFR 677TT genotype was significantly higher in patients with total migraine (AOR, 3.32; 95% CI, 1.30~9.55; p< 0.05) and with MWA (AOR, 4.70; 95% CI, 1.44~15.29; p<0.01) than the controls. However, the AOR was not significant in patients with tension headache (AOR, 0.93; 95% CI, 0.37~2.32) and with MOA (AOR, 2.77; 95% CI, 0.78~9.74). Conclusions: Our findings suggest that both elevated homocysteine level and the homozygous C677T mutation in the MTHFR gene are associated with migraine with aura.

참고문헌 (22)

  1. "Classification and diagnostic criteria for headache disorders,cranial neuralgias and facial pain", 8, pp.1~96 (1988)
  2. "The impact of migraine on quality of life in the general population:the GEM study", 55, pp.624~629 (2000)
  3. "Migraine, quality of life, and depression: a population- based case-control study", 55, pp.629~635 (2000)
  4. "The Homozygous C677T Mutation in the Methylenetetrahydrofolate Reductase Gene Is a Genetic Risk Factor for Migraine", 96, pp.762~764 (2000)
  5. "Plasma homocysteine levels in primary headache. In: Olesen J, Edvinsson L, editors. Headache pathogenesis: monoamines, neuropeptides, purines, and nitric oxide", mo, pp.215~218 (1997), Philadelphia: Lippincott-Raven Publishers
  6. "Hyperhomocysteinemia:an independent risk factor for vascular disease", 324, pp.1149~1155 (1999)
  7. "A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians", 268, pp.877~881 (1992)
  8. "A quantitative assessment of plasma homocysteine as a risk factor for vascular disease.Probable benefits of increasing folic acid intakes", 274, pp.1049~1057 (1995)
  9. "Plasma homocysteine as a risk factor for vascular disease:The Europian Concerted Action Project", 277, pp.1775~1781 (1977)
  10. "Lowering blood homocysteine with folic acid based supplements:meta-analysis of randomized trials", 316, pp.894~898 (1998)
  11. "Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease", 338, pp.1009~1015 (1998)
  12. "Is blood homocysteine elevated in migraine", 41, pp.779~781 (2001)
  13. "Increased familial risk and evidence of genetic factor in migraine", 311, pp.541~544 (1995)
  14. "Migraine headache:diagnosis and management", 19, pp.133~141 (1979)
  15. "Studies on headache.Electroenceph- alographic abnormalities in patients with vascular headache of the migraine type", 4, pp.475~485 (1961)
  16. "Neurovascular and molecular mechanisms in migraine headaches", 5, pp.159~177 (1993)
  17. "Genetic heterogeneity of familial hemiplegic migraine", 22, pp.21~26 (1994)
  18. "Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4", 87, pp.543~552 (1996)
  19. "Microiontophoretic application of serotonin(5HT)1B", 1D agonist inhibits trigeminal cell firing in the cat, 1997, pp.120, 2171~2177
  20. "Impaired homocysteine metabolism and atherothrombotic disease", 81, pp.645~672 (2001)
  21. "Clinical chemistry and molecular biology of homocysteine metabolism an update", 30, pp.189~201 (1997)
  22. "Clinical chemistry and molecular biology of homocysteine metabolism an update", 30, pp.189~201 (1997)

관련 논문AI추천

MTHFR C677T 유전자 다형성과 허혈성 뇌졸중의 상관 관계김숙희, 김지영, 김희진, 박기덕, 윤지영, 이정화, 조현지, 최경규, 최병옥대한신경과학회 · 대한신경과학회지2005 · 제23권 제5호Genetic Contribution of Catechol-O-methyltransferase Polymorphism in Patients with Migraine without Aura김영인, 김중석, 박정욱, 신혜은, 이광수대한신경과학회 · Journal of Clinical Neurology2007 · 제3권 제1호뇌경색 환자에서 고호모시스테인혈증과 C677T MTHER 유전자 다형성의 상관 관계김남근, 김상범, 김선희, 김옥준, 김현조, 서정호, 오도연, 이규용, 정경천, 정보우, 최병옥대한신경과학회 · 대한신경과학회지2002 · 제20권 제4호Screening of the A11084G Polymorphism and Scanning of a Mitochondrial Genome SNP in Korean Migraineurs강나미, 김만호, 김병건, 김성찬, 김성훈, 이순태, 임우석대한신경과학회 · Journal of Clinical Neurology2007 · 제3권 제3호Influence of Combined Methionine Synthase (MTR 2756A>G) and Methylenetetrahydrofolate Reductase (MTHFR 677C>T) Polymorphisms to Plasma Homocysteine Levels in Korean Patients with Ischemic Stroke김남근, 김수옥, 김옥준, 안정용, 오도연, 유왕돈, 홍선표, 홍승호, 황태선연세대학교의과대학 · Yonsei Medical Journal2007 · 제48권 제2호MTHFR유전자의 이형접합변이(C677T)를 동반한 대뇌정맥동혈전증채솔, 윤동민, 임성민, 장상현대한신경과학회 · 대한신경과학회지2022 · 제40권 제4호

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