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파킨슨병에서 촉각공간해상능력의 장애

Impaired Tactile Spatial Discrimination in Parkinson’s disease

신혜원|강석윤|손영호
대한신경과학회 (Korean Neurological Association)|2005.06|대한신경과학회지 (Journal of the Korean Neurological Association)|제23권 제3호|pp. 330-334

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참고문헌

주제분류신경과학

초록

Abstract

Background: The basal ganglia plays a major role in regulating motor, cognitive and emotional functions. In addition, it has been proposed that the functions of the basal ganglia is also related to control of sensory discrimination and sensorimotor integration. One possible way to test this hypothesis would be to investigate sensory functions in patients with various diseases affecting basal ganglia functions. Since idiopathic Parkinson’s disease (IPD) is caused by selective impairment of basal ganglia functions, it could be a good model for this purpose. Methods: We measured the grating resolution threshold (GRT) using the JVP (Johnson-Van Boven-Phillips) dome in 52 patients with IPD and 25 age-matched healthy controls. Statistical analysis employed unpaired t-test, paired t-test and simple regression analysis. P-values less than 0.05 were considered as significant. Results: Patients showed significantly higher GRT than controls (3.07±0.74 vs 2.03±0.80; p<0.05). In patients, the mean GRT was not different between symptomatically dominant and non-dominant hands (3.10±0.95 vs 2.93±0.82). In the patients with hemiparkinsonism, GRT was also significantly higher in asymptomatic hands compared with controls (3.00±0.71 vs 2.03±0.80; p<0.05). The severity of sensory dysfunction in patients was not correlated with symptom duration or to symptom severity, measured by the modified Columbia rating scale (MCRS). Conclusions: The present results demonstrate that spatial discrimination is impaired in IPD, suggesting the basal ganglia plays a role in sensory regulation.

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컴퓨터화 자세측정기를 이용한 파킨슨병 환자의 균형 조절 능력에 대한 평가곽현, 김상범, 김원복, 김재우, 윤기성, 이건철, 이경우, 천상명대한재활의학회 · Annals of Rehabilitation Medicine2007 · 제31권 제2호파키슨씨 병에서의 자율신경검사이원용대한임상신경생리학회 · Annals of Clinical Neurophysiology2002 · 제4권 제2호감각기능 회복을 보인 피질하 뇌졸중 환자의 체성감각영역 활성화 양상이지인대한재활의학회 · Annals of Rehabilitation Medicine2005 · 제29권 제5호기저핵 운동회로와 파킨슨 증상의 신경생리손영호대한임상신경생리학회 · Annals of Clinical Neurophysiology2006 · 제8권 제2호파킨슨병 환자에서의 허리통증 특성김미선, 김성렬, 성영희, 이명종, 정선주대한신경과학회 · 대한신경과학회지2006 · 제24권 제5호파킨슨병 환자의 수면장애유수연, 조용원대한수면연구학회 · Journal of sleep medicine2014 · 제11권 제2호

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